Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

---

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977

Published: Aug. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Language: Английский

---

Tumor Microenvironment-Activable Manganese-Boosted Catalytic Immunotherapy Combined with PD-1 Checkpoint Blockade

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 20400 - 20418

Published: Nov. 28, 2022

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer treatment. Due to the low immunogenicity and immune suppression state tumor microenvironment (TME), therapeutic effects are only moderate. Herein, a TME-activable manganese-boosted catalytic immunotherapy is designed for synergism with ICB kill tumors efficiently. The cell membrane (CM)-wrapping multienzyme-mimic manganese oxide (MnOx) nanozyme termed CM@Mn showed intrinsic peroxidase oxidase-like activities an acidic TME. These can generate toxic hydroxyl (•OH) superoxide radicals (•O2-) killing evoking immunogenic death (ICD). Furthermore, TME-responsive release of Mn2+ directly promotes dendritic maturation macrophage M1 repolarization, resulting reversal immunosuppressive TME into immune-activating environment. Additionally, hypoxia relief caused by catalase-like activity also contributes process reversal. Finally, robust tumor-specific T cell-mediated antitumor response occurs support PD-1 blockade. proliferation primary metastatic was inhibited, long-term memory effect induced. strategy outlined here may serve as promising candidate tumor-integrated

Language: Английский

---

Bimetal-organic framework/GOx-based hydrogel dressings with antibacterial and inflammatory modulation for wound healing

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 158, P. 252 - 265

Published: Dec. 27, 2022

Language: Английский

---

A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca²⁺‐Overload‐Enhanced Catalytic Tumor Nanotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(43)

Published: Sept. 15, 2022

The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation reactive oxygen species (ROS) caused by valence change metal elements. However, very little research focused on and has achieved exploration development enzyme-mimicking activities valence-invariable compounds. Herein, a distinct calcium fluoride (CaF2 ) nanozyme ultrasound (US)-enhanced peroxidase (POD)-mimicking activity rationally designed engineered efficient (Ca2+ )-overload-enhanced catalytic tumor nanotherapy, which first paradigm Ca-based cancer treatment. release exogenous Ca2+ ions from CaF2 nanocrystals deleterious ROS derived US-amplified POD-mimicking properties facilitate intracellular accumulation achieve -overload-induced mitochondrial dysfunction through introducing regulating calcium-pumping channels neoplastic cells. Especially, US as an energy input capable substantially amplifying nanozyme, ultimately achieving anti-neoplastic outcome both 4T1 breast H22 hepatic carcinoma animal models. Such discovery enzyme-like compounds can broaden cognition scope effectively serves field chemoreactive nanomedicine.

Language: Английский

---

Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(15), P. 18608 - 18619

Published: April 10, 2023

Bacterial infection and excess reactive oxygen species are key factors that lead to slow or substantially delayed wound healing. It is crucial design develop new nanomaterials with antibacterial antioxidative capabilities for Here, positively charged carbon dots (CDs) rationally designed synthesized from p-phenylenediamine polyethyleneimine by a facile one-pot solvothermal method, which show good biocompatibility in vitro cytotoxicity, hemolysis assays, vivo toxicity evaluation. The CDs superior antimicrobial effect against Staphylococcus aureus (S. aureus) at very low concentrations, reducing the risk of infection. At same time, surface defects unpaired electrons can effectively scavenge free radicals reduce oxidative stress damage, accelerate inflammation-proliferation transition, promote mouse model skin demonstrates healing without obvious side effects simply dropping spraying onto wound. We believe prepared have satisfactory biocompatibility, antioxidant capacity, excellent activity great application potential

Language: Английский

---

CuCo₂O₄ Nanoflowers with Multiple Enzyme Activities for Treating Bacterium-Infected Wounds via Cuproptosis-like Death

ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15845 - 15863

Published: June 4, 2024

Nanozyme-driven catalytic therapy provides a promising treatment strategy for bacterial biofilm-infected wounds. However, the single functionality and limited efficiency of nanozyme-based materials often restrict effectiveness wound infection treatment. In this study, CuCo2O4 nanoflowers with multiple enzymatic activities were prepared antibacterial/antibiofilm by cuproptosis-like death. exhibited peroxidase-like (POD-like) oxidase-like (OXD-like) dual enzyme that generated large amounts •OH O2•–. Moreover, glutathione (GSH-Px-like) activity was able to reduce overexpression GSH in microenvironment, enhancing therapeutic effects reactive oxygen species (ROS). The morphology modified using hydrothermal method PEG4000 as solvent, resulting exposure more active center sites significant improvement activity. vitro results demonstrated pronounced disruption effect on biofilms formed bacteria. vivo, significantly promoted angiogenesis, collagen deposition, cell proliferation. Transcriptome sequencing revealed elevated ROS levels bacteria led membrane damage metabolic disruption. addition, Cu2+ overload induces lipid peroxidation accumulation disrupts respiratory chain tricarboxylic acid (TCA) cycle, ultimately leading This strategy, which combines synergistic enzyme-like death, an approach treating biofilm infections.

Language: Английский

---

Multifunctional MnCo@C yolk-shell nanozymes with smartphone platform for rapid colorimetric analysis of total antioxidant capacity and phenolic compounds

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 216, P. 114652 - 114652

Published: Aug. 24, 2022

Language: Английский

---

Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 167, P. 449 - 462

Published: June 2, 2023

Language: Английский

---

An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re‐Epithelization and Skin Constriction for Enhancing Wound Closure

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 9, 2024

Abstract Delayed re‐epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large‐scale acute or chronic wounds. However, effective strategies for targeting these aspects concurrently still lacking. Herein, an antioxidative active‐shrinkage hydrogel (AHF@AS Gel) is constructed can integratedly promote constriction to accelerate diabetic closure. The AHF@AS Gel encapsulated by amino‐ hydroxyl‐modified C 70 fullerene (AHF) a thermosensitive active shrinkage (AS Gel). Specifically, AHF relieves overactivated inflammation, prevents cellular apoptosis, promotes fibroblast migration vitro reducing excessive reactive oxygen species (ROS). Notably, achieved ≈2.7‐fold ≈1.7‐fold better wounds wounds, respectively, significantly contributing promotion of Using proteomic profiling mechanistic studies, it identified efficiently promoted transition inflammatory proliferative phases remodeling phase. demonstrated AS alone activates mechanosensitive epidermal growth factor receptor/Akt (EGFR/Akt) pathway cell proliferation. offers comprehensive strategy via biochemistry regulation integrating with mechanical forces stimulation.

Language: Английский

---