Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 14, 2025

Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.

Language: Английский

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A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654

Published: Jan. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Language: Английский

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Therapeutic applications of nanobiotechnology

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 6, 2023

Abstract Nanobiotechnology, as a novel and more specialized branch of science, has provided number nanostructures such nanoparticles, by utilizing the methods, techniques, protocols other branches science. Due to unique features physiobiological characteristics, these or nanocarriers have vast methods therapeutic against microbial infections cancers for tissue regeneration, engineering, immunotherapies, gene therapies, through drug delivery systems. However, reduced carrying capacity, abrupt non-targeted delivery, solubility agents, can affect applications biotechnological products. In this article, we explored discussed prominent nanobiotechnological products nanocarriers, highlighted challenges associated with products, attempted conclude if available offer any scope improvement enhancement. We aimed identify emphasize greater prospect capacity improvements enhancements. found that nanostructures, nanocomposites, micelles, hydrogels, microneedles, artificial cells, address inherited drawbacks, help conjugations, sustained stimuli-responsive release, ligand binding, targeted delivery. recommend nanobiotechnology, despite having few offers immense opportunities be harnessed in delivering quality therapeutics precision prediction. also that, exploring branched domains rigorously, bottlenecks obstacles addressed resolved return. Graphical

Language: Английский

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Recent advances in nanotechnology

International Journal of Nanomaterials Nanotechnology and Nanomedicine, Journal Year: 2023, Volume and Issue: 9(2), P. 015 - 023

Published: Sept. 15, 2023

Introduction: Recent advances in nanotechnology have shown significant progress various fields. Nanotechnology involves the manipulation and control of matter at nanoscale, typically ranging from 1 to 100 nanometers. This field has potential revolutionize industries such as electronics, medicine, energy, materials science. led development smaller more efficient devices electronics. Nanoscale transistors memory chips increased computing power storage capacity. Additionally, nanomaterials like carbon nanotubes graphene promise creating flexible transparent Method materials: In opened new possibilities for targeted drug delivery imaging. Nanoparticles can be designed specifically target cancer cells, delivering drugs directly affected area while minimizing side effects. Nano-sensors also used early detection diseases monitoring patient health. Energy is another where made advancements. Nanomaterials quantum dots nanowires improved efficiency solar making them cost-effective sustainable. plays a role energy storage, with high-capacity batteries supercapacitors. Materials science benefited nanotechnology. Nanocomposites, which are nanoscale fillers, enhanced mechanical, thermal, electrical properties. These find applications aerospace, automotive, construction industries. Conclusion: Overall, recent paved way exciting Continued research this hold further breakthroughs advancements future.

Language: Английский

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RGD-engineered nanoparticles as an innovative drug delivery system in cancer therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104562 - 104562

Published: May 13, 2023

Language: Английский

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A global assessment of incidence trends of autoimmune diseases from 1990 to 2019 and predicted changes to 2040

Autoimmunity Reviews, Journal Year: 2023, Volume and Issue: 22(10), P. 103407 - 103407

Published: Aug. 11, 2023

Language: Английский

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525

Published: Jan. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Language: Английский

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Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 213 - 213

Published: Feb. 8, 2024

This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties ZnO-NPs was analyzed. cytotoxicity reactive oxygen species (ROS) generation capacity were evaluated against breast (MCF7) colon (HT29) cancer cell lines. Their antioxidant activity analyzed using DPPH assay, their toxicity towards Artemia salina nauplii also evaluated. results revealed that treatment with NPs resulted in death 10.559–42.546% 18.230–38.643% MCF7 HT29 cells, respectively. attributed ability downregulate ROS formation within two lines dose-dependent manner. In inhibited free radicals at IC50 values ranging from 3.898 126.948 μg/mL. Against A. nauplii, synthesized did not cause nor induce changes tested concentrations. A series machine learning (ML) models predict biological performance ZnO-NPs. Among designed ML models, gradient boosting model greatest mean absolute error (MAE) (MAE 9.027, R2 = 0.86). data generated this work provide innovative insights into influence La Sm structural arrangement chemical features ZnO-NPs, together cytotoxicity, activity, vivo toxicity.

Language: Английский

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Antigen‐specific mRNA lipid nanoparticle platforms for the prevention and treatment of allergy and autoimmune diseases

BMEMat, Journal Year: 2023, Volume and Issue: 2(2)

Published: Dec. 14, 2023

Abstract While most nanomedicines primarily aim to stimulate the immune system against infections or tumors, there is a growing demand for inducing tolerance under certain conditions, such as allergic and autoimmune diseases. Researchers have explored nanotechnology‐based strategies induce in targeted specific manner. One approach involves use of nanoparticles (NPs) encapsulate immunosuppressive drugs and/or antigens educate naïve T cells promote generation antigen‐specific regulatory that inhibit responses. However, this has limitations. The hydrophobicity proteins peptides restricts degree which they can be encapsulated NPs, turn, affects their loading efficiency treatment efficacy. With emergence mRNA lipid nanoparticle (LNP) platforms, possibility overcoming limitations protein peptide encapsulation. To date, LNP systems been shown provide organ, cellular, subcellular targeting induction tolerance. This method drug delivery flexible scalable customized patient, resulting an effective means administering relevant epitopes continued research development, technology could offer safer more alternative current therapies, ultimately improving quality life patients worldwide.

Language: Английский

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A scientometric analysis and up-to-date review of nano-based drug delivery systems in glioblastoma treatment

Nano Today, Journal Year: 2023, Volume and Issue: 52, P. 101961 - 101961

Published: Aug. 14, 2023

Language: Английский

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