Recent
advancements
in
gut
microbiome
research
have
highlighted
the
complex
interplay
between
microbiota
and
various
physiological
pathological
processes,
showing
that
plays
a
vital
role
human
health
disease.
Imbalances
microbiota,
known
as
dysbiosis,
been
associated
with
range
of
conditions,
including
gastrointestinal
disorders,
metabolic
diseases,
etc.
In
response
to
these
findings,
probiotics,
prebiotics,
synbiotics,
postbiotics
emerged
promising
therapeutic
strategy
modulate
composition
functionality.
This
review
paper
explores
latest
on
how
impacts
host
physiology,
immune
responses,
overall
well-being.
Furthermore,
delves
into
potential
postbiotics,
synbiotics
applications
curing
diseases.
The
also
addresses
challenges
opportunities
field,
highlighting
need
for
personalized
approaches
probiotic
therapy
importance
considering
factors
such
strain
specificity,
dosing,
safety.Overall,
this
aims
provide
comprehensive
overview
evolving
landscape
novel
agents.
It
underscores
harnessing
improve
health,
prevent
complement
traditional
medical
interventions.
As
field
continues
expand,
deeper
understanding
promises
new
avenues
preventive
healthcare
strategies.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Biofilm,
Journal Year:
2024,
Volume and Issue:
7, P. 100192 - 100192
Published: March 15, 2024
The
increasing
incidence
of
antimicrobial
resistance
exhibited
by
biofilm-forming
microbial
pathogens
has
been
recognized
as
one
the
major
issues
in
healthcare
sector.
In
present
study,
nanomaterial-based
controlling
biofilm
and
virulence
properties
considered
an
alternative
approach.
Pyoverdine
(PVD)
isolated
from
Pseudomonas
aeruginosa
was
utilized
a
biological
corona
to
synthesize
silver
nanoparticles
(AgNPs),
which
will
be
helpful
targeted
action
due
recognition
pathogenic
membrane.
Synthesized
PVD-AgNPs
were
spherical
irregular,
with
average
size
value
251.87
±
21.8
nm
zeta
potential
−36.51
0.69
mV.
MIC
towards
P.
aeruginosa,
Listeria
monocytogenes,
Staphylococcus
aureus,
Streptococcus
mutans,
Escherichia
coli,
Candida
albicans
standard
host-mimicking
media
observed
decreasing
order
multi-fold,
such
growth
>
sputum
synthetic
human
urine
saliva.
Both
initial
stage
well-established
biofilms
these
have
effectively
inhibited
eradicated
PVD-AgNPs.
increase
susceptibility
tetracycline,
PVD,
amphotericin
B
established
mature
mono-
mixed-species
S.
aureus
C.
albicans.
Additionally,
attenuate
several
properties,
inhibition
protease
activity,
motility,
PVD
pyocyanin
production
aeruginosa.
gene
expression
virulence-associated
genes
validates
its
phenotypic
effects.
Future Journal of Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Dec. 11, 2023
Abstract
Background
Nanoparticles
have
emerged
as
a
viable
biological
candidate
with
the
possibility
to
be
employed
drug
carriers.
They
acquire
high
surface-to-volume
ratios
and
unique
physicochemical
features
such
biochemical,
magnetic,
optical,
electrical
changes
at
cellular,
atomic,
molecular
levels.
This
phenomenon
has
proven
extensive
utility
for
biomedical
applications,
their
activity
fewer
adverse
effects
than
traditional
medications.
Main
body
of
abstract
The
new
spectrum
nanomaterials—nanomedicines—has
accomplished
disease
management
by
detecting,
restoring,
regeneration
damaged
tissues.
Therefore,
designing
appropriate
nanomaterial-based
delivery
systems
final
clinical
evaluations
requires
accurate
knowledge
pharmacokinetic
factors
relevant
LADME
in
order
meet
required
criteria
(liberation,
adsorption,
distribution,
metabolism,
elimination).
To
identify
predict
vivo
reaction
nanoparticles,
deeper
understanding
link
between
properties
nanomaterials
contact
is
necessary.
will
allow
distinguished
comparison
medicines
nanoparticles.
Short
conclusion
review
paper
attempts
analyze
basic
potential
nanoparticles
depth.
profiling
analysis
enable
us
treatment
outcome
overcome
properties,
provide
broad
overview,
deliver
remarkable
ways
advance
use
industry.
Graphical
Biomedical Physics & Engineering Express,
Journal Year:
2023,
Volume and Issue:
9(5), P. 052002 - 052002
Published: Aug. 7, 2023
Abstract
Nanomedicine
and
nano-delivery
systems
hold
unlimited
potential
in
the
developing
sciences,
where
nanoscale
carriers
are
employed
to
efficiently
deliver
therapeutic
drugs
at
specifically
targeted
sites
a
controlled
manner,
imparting
several
advantages
concerning
improved
efficacy
minimizing
adverse
drug
reactions.
These
target-oriented
delivery
of
with
precision
site-specific,
mild
toxicity,
prolonged
circulation
time,
high
solubility,
long
retention
time
biological
system,
which
circumvent
problems
associated
conventional
approach.
Recently,
nanocarriers
such
as
dendrimers,
liposomes,
nanotubes,
nanoparticles
have
been
extensively
investigated
through
structural
characteristics,
size
manipulation,
selective
diagnosis
disease
imaging
molecules,
very
effective
introduce
new
paradigm
shift
drugs.
In
this
review,
use
nanomedicines
has
demonstrated
treating
various
diseases
significant
advances
applications
different
fields.
addition,
review
discusses
current
challenges
future
directions
for
research
these
promising
fields
well.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(18)
Published: April 8, 2024
Increasing
the
penetration
and
accumulation
of
antitumor
drugs
at
tumor
site
are
crucial
in
chemotherapy.
Smaller
drug-loaded
nanoparticles
(NPs)
typically
exhibit
increased
more
effective
permeation
through
nuclear
membrane,
whereas
larger
NPs
show
extended
retention
site.
In
addition,
cancer
stem
cells
(CSCs)
have
unlimited
proliferative
potential
for
onset,
progression,
metastasis
cancer.
Therefore,
a
amphiphilic
peptide,
DDP-
ATRA-loaded
Pep1
(DA/Pep1),
is
designed
that
self-assembles
into
spherical
upon
encapsulation
cis-diamminedichloroplatinum
(DDP)
all-trans
retinoic
acid
(ATRA).
an
acidic
environment,
DA/Pep1
transforms
aggregates
containing
sheet-like
structures,
which
significantly
increases
drug
site,
thereby
increasing
effects
inhibiting
metastasis.
Moreover,
although
DDP
treatment
can
increase
number
CSCs
present,
ATRA
induce
differentiation
breast
to
therapeutic
effect
DDP.
conclusion,
this
peptide
nanodelivery
system
response
microenvironment
extremely
promising
nanoplatform
suggests
new
idea
combined
tumors.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1726 - 1726
Published: June 14, 2023
The
objective
of
this
study
was
to
investigate
the
rhombohedral-structured,
flower-like
iron
oxide
(Fe2O3)
nanoparticles
that
were
produced
using
a
cost-effective
and
environmentally
friendly
coprecipitation
process.
structural
morphological
characteristics
synthesized
Fe2O3
analyzed
XRD,
UV-Vis,
FTIR,
SEM,
EDX,
TEM,
HR-TEM
techniques.
Furthermore,
cytotoxic
effects
on
MCF-7
HEK-293
cells
evaluated
in
vitro
cell
viability
assays,
while
antibacterial
activity
against
Gram-positive
Gram-negative
bacteria
(Staphylococcus
aureus,
Escherichia
coli,
Klebsiella
pneumoniae)
also
tested.
results
our
demonstrated
potential
toward
lines.
antioxidant
evidenced
by
1,1-diphenyl-2-picrylhydrazine
(DPPH)
nitric
(NO)
free
radical
scavenging
assays.
In
addition,
we
suggested
could
be
used
various
applications
prevent
spread
different
bacterial
strains.
Based
these
findings,
concluded
have
great
for
use
pharmaceutical
biological
applications.
effective
biocatalytic
recommends
its
as
one
best
drug
treatments
future
views
cancer
cells,
it
is,
therefore,
recommended
both
vivo
biomedical
field.
