Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

---

Nanoprobe-based molecular imaging for tumor stratification

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

---

Programmed Targeting Pyruvate Metabolism Therapy Amplified Single‐Atom Nanozyme‐Activated Pyroptosis for Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: Feb. 7, 2024

Abstract Increasing cellular immunogenicity and reshaping the immune tumor microenvironment (TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single‐atom nanozyme pyroptosis initiator: UK5099 pyruvate oxidase (POx)‐co‐loaded Cu‐NS (Cu‐NS@UK@POx), that not only trigger through cascade biocatalysis to boost of cells, but also remodel immunosuppressive TME by targeting metabolism. By replacing N with weakly electronegative S, original spatial symmetry Cu‐N 4 electron distribution is changed enzyme‐catalyzed process effectively regulated. Compared spatially symmetric nanozymes (Cu‐N SA), S‐doped asymmetric (Cu‐NS SA) exhibit stronger activities, including peroxidase (POD), nicotinamide adenine dinucleotide (NADH) (NOx), L ‐cysteine (LCO), glutathione (GSHOx), which can cause enough reactive oxygen species (ROS) storms pyroptosis. Moreover, synergistic effect SA, UK5099, POx target metabolism, improves increases degree This study provides two‐pronged treatment strategy significantly activate immunotherapy effects via ROS storms, NADH/glutathione/ consumption, oxidation, lactic acid (LA)/ATP depletion, triggering regulating broad vision expanding

Language: Английский

---

Oxygen‐carrying semiconducting polymer nanoprodrugs induce sono‐pyroptosis for deep‐tissue tumor treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 19, 2024

Abstract Sonodynamic therapy (SDT) has been explored for cancer therapy, especially deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited the complicated tumor microenvironment. This study reports construction oxygen‐carrying semiconducting polymer nanoprodrugs (OSPN pro ) treatment via combining amplified with pyroptosis. An oxygen carrier perfluorohexane, sonodynamic as sonosensitizer, and reactive species (ROS)‐responsive prodrug are co‐loaded into a nanoparticle system, leading formation these nanoprodrugs. Such OSPN show an effective accumulation in tissues after systemic administration, which they deliver relieve hypoxia microenvironment thus mediate producing ROS under ultrasound (US) irradiation, even when covered 2‐cm chicken breast tissue. In addition, ROS‐responsive prodrugs activated by generated trigger pyroptosis cells. sono‐pyroptosis induces strong antitumor immunity obviously higher level infiltrations effector immune cells tumors. Therefore, ‐based combinational can greatly inhibit growth tissue‐covered suppress metastasis. offers nanoplatform strategy.

Language: Английский

---

Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis

Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122472 - 122472

Published: Jan. 23, 2024

Language: Английский

---

Recent strategies for evoking immunogenic Pyroptosis in antitumor immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 375 - 394

Published: Jan. 9, 2024

Pyroptosis is a specific type of programmed cell death (PCD) characterized by distinct morphological changes, including swelling, membrane blebbing, DNA fragmentation, and eventual lysis. closely associated with human-related diseases, such as inflammation malignancies. Since the initial observation pyroptosis in Shigella flexneri-infected macrophages more than 20 years ago, various pyroptosis-inducing agents, ions, small molecules, biological nanomaterials, have been developed for tumor treatment. Given that can activate body's robust immune response against promote formation long-term memory treatment, its status immunogenic self-evident. Therefore, should be used powerful anti-tumor strategy. However, there still lack comprehensive summary most recent advances pyroptosis-based cancer therapy. it vital to fill this gap inspire future drug design better induce cells undergo achieve advanced effects. In review, we summarize detail triggering adequate clearance based on treatment modalities, highlight material therapeutic advantages. Besides, also provide an outlook prospects emerging field next development.

Language: Английский

---

Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 219 - 231

Published: May 4, 2023

Language: Английский

---

Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146276 - 146276

Published: Oct. 11, 2023

Language: Английский

---

Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity

Advanced Science, Journal Year: 2023, Volume and Issue: 11(3)

Published: Nov. 20, 2023

Abstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of inducers or regulators may bring about severe side effects that also be rapidly excreted degraded low efficacy. Nanomaterials able carry them for long circulation time, high tumor accumulation controlled release achieve satisfactory effect. Nowadays, large number studies focused on nanomedicines‐based strategies through modulating modalities potentiate immunity. Herein, types their function first summarized, state‐of‐the‐art research progresses in nanomedicines mediated pathways (e.g., cuproptosis) response provocation highlighted. Subsequently, the conclusion outlook potential focus discussed.

Language: Английский

---

A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16967 - 16981

Published: June 18, 2024

Selective generation of sufficient pyroptosis inducers at the tumor site without external stimulation holds immense significance for a longer duration immunotherapy. Here, we report cascade-amplified inducer CSCCPT/SNAP that utilizes reactive nitrogen species (RNS), self-supplied from diffusion-controlled reaction between oxygen (ROS) and nitric oxide (NO) to potentiate immunotherapy, while both endogenous mitochondrial ROS stimulated by released camptothecin NO initiate pyroptosis. Mechanistically, cascade amplification antitumor immune response is prompted cooperation enhanced RNS with long lifetime, which could be used as trigger effectively compensate inherent drawbacks ROS, resulting in long-lasting favoring Tumor growth efficiently inhibited mouse melanoma tumors through facilitation oxygen/nitrogen (RONS)-NO synergy. In summary, our therapeutic approach supramolecular engineering nanotechnology integrate producers donors tumor-specific stimulus responses into system guarantees synchronous these two elicit pyroptosis-evoked response, using amplifier. RONS-NO synergy achieves sustained robust cancer

Language: Английский

---