Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 6, 2024
Abstract
Tailored
photophysical
properties
and
chemical
activity
is
the
ultimate
pursuit
of
functional
dyes
for
in
vivo
biomedical
theranostics.
In
this
work,
independent
regulation
absorption
fluorescence
emission
wavelengths
heptamethine
cyanines
reported.
These
retain
near‐infrared
(except
a
nitro‐modified
dye)
while
feature
variable
ranging
from
590
to
860
nm.
This
enables
obtain
customized
that
meet
excitation
wavelength
requirements
defined
by
optical
tissues
applications.
Typically,
photothermal
active
derivative
Cy‐Mu‐7‐9
used,
which
features
strong
at
810
nm
PBS,
balanced
tissue
penetration
depth
non‐specific
effect,
realize
non‐destructive
inflammatory
bowel
disease
(IBD)
therapy
via
induced
up‐regulation
heat
shock
protein
70
intestinal
epithelial
cells.
The
corresponding
amino‐modified
dye
Cy‐Mu‐7‐9‐NH
2
,
can
be
formed
health
enteric
cavity
after
oral
administration,
compound
with
800
PBS.
Based
on
IBD
sensitive
transformation
theranostic
therapeutic
effect
evaluation
realized
synergy
imaging
first
time.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
The
two
contradictory
entities
in
nature
often
follow
the
principle
of
unity
opposites,
leading
to
optimal
overall
performance.
Particularly,
aggregation-induced
emission
luminogens
(AIEgens)
with
donor–acceptor
(D–A)
structures
exhibit
tunable
optical
properties
and
versatile
functionalities,
offering
significant
potential
revolutionize
cancer
treatment.
However,
trapped
by
low
molar
absorptivity
(ε)
owing
distorted
configurations,
ceilings
their
photon-harvesting
capability
corresponding
phototheranostic
performance
still
fall
short.
Therefore,
a
research
paradigm
from
twisted
configuration
near-planar
structure
featuring
high
ε
is
urgently
needed
for
AIEgens
development.
Herein,
introducing
strategy
"motion
stillness"
into
highly
planar
A–D–A
skeleton,
we
successfully
developed
near-infrared
(NIR)-II
AIEgen
Y5-2BO-2BTF,
which
boasts
an
impressive
1.06
×
105
M–1
cm–1
photothermal
conversion
efficiency
(PCE)
77.8%.
modification
steric
hindrance
on
benzene
ring
acceptor
unit
aggregation-caused
quenching
counterpart
Y5-2BO,
meta-CF3-substituted
naphthyl,
leads
reversely
staggered
packing
various
intermolecular
noncovalent
conformational
locks
Y5-2BO-2BTF
("stillness").
Furthermore,
−CF3
moiety
acted
as
flexible
motion
ultralow
energy
barrier,
significantly
facilitating
process
loose
aggregates
("motion").
Accordingly,
nanoparticles
enabled
tumor
eradication
pulmonary
metastasis
inhibition
through
NIR-II
fluorescence-photoacoustic-photothermal
imaging-navigated
type
I
photodynamic-photothermal
therapy.
This
work
provides
first
evidence
that
conformation
stacking
arrangement
could
serve
novel
molecular
design
direction
AIEgens,
shedding
new
light
constructing
superior
agents
bioimaging
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 2, 2024
Abstract
Phototheranostics
has
garnered
sustained
attention
due
to
its
significant
potential
for
revolutionizing
conventional
cancer
treatment
strategies.
While
being
one
of
the
most
commonly
employed
strategies
constructing
phototheranostic
systems
by
engineering
integration
photosensitizers
(PSs)
into
nanosystems,
nano‐PSs
face
challenges
including
complexity
in
preparation
process,
low
delivery
efficiency,
and
toxicity
issues.
Contrastingly,
burgeoning
popularity
small
molecule
PSs
characterized
aggregation‐induced
emission
(AIE)
become
evident
arena
phototheranostics.
This
preference
is
underscored
their
well‐defined
structures,
adjustable
photophysical
properties,
toxicity.
Therefore,
acquiring
profound
insights
pioneering
strides
achievable
through
a
solitary
PS
with
AIE
tumor
phototheranostics
paramount
scientific
significance.
In
this
review,
we
will
discuss
recent
progress
properties
diagnosis
phototherapies
representative
examples,
guided
ethos
“Complexity
made
easy”.
We
also
look
forward
future
development
direction
molecules,
central
objective
advancing
research
focal
emphasis
on
simplicity,
expeditiousness,
safety.
National Science Review,
Journal Year:
2025,
Volume and Issue:
12(3)
Published: Jan. 10, 2025
Osteosarcoma
(OS),
a
highly
aggressive
bone
tumor,
presents
significant
challenges
in
terms
of
effective
treatment.
We
identified
that
cellular
autophagy
was
impaired
within
OS
by
comparing
clinical
samples
through
bioinformatic
analyses
and
further
validated
the
inhibition
mitochondrial
at
transcriptomic
level.
Based
on
this
finding,
we
investigated
therapeutic
potential
dual
functional
metal
nanoplatform
(MnSx)
to
facilitate
transition
from
protective
effect
low-level
killing
high-level
OS.
MnSx
facilitated
intracellular
H2S
generation
via
endocytosis,
leading
S-sulfhydration
ubiquitin-specific
peptidase
8
(USP8)
subsequent
promotion
vitro.
Additionally,
activated
cyclic
guanosine
monophosphate-adenosine
monophosphate
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
enhancing
autophagic
response
accelerating
tumor
cell
death.
Moreover,
it
demonstrated
vivo
MnSx,
one
hand,
mediated
activation
USP8
H2S,
while
Mn2+
promoted
maturation
dendritic
cells,
cytotoxic
T
lymphocytes
contributed
eradication.
Such
could
be
suppressed
inhibitor
chloroquine.
Importantly,
synergistic
combination
therapy
with
immune
checkpoint
inhibitors
showed
promise
for
achieving
complete
remission
This
study
highlights
as
dual-functional
platform
treatment
offers
novel
directions
future
research
field.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Revealing
changes
in
the
tumor
microenvironment
is
crucial
for
understanding
cancer
and
developing
sensitive
methods
precise
imaging
diagnosis.
Intracellular
hydrogen
peroxide
(H2O2)
microenvironmental
factors
(e.g.,
viscosity
polarity)
are
closely
linked
to
various
physiological
pathological
processes,
making
them
potential
biomarkers
cancer.
However,
a
triple-response
theranostic
probe
therapy
has
not
yet
been
achieved
due
lack
of
effective
tools.
Herein,
we
present
mitochondria-targeting
near-infrared
(NIR)
fluorescent
probe,
VPH-5DF,
capable
simultaneously
monitoring
H2O2,
viscosity,
polarity
through
dual
NIR
channels.
The
specifically
detects
H2O2
via
emission
(λem
=
650
nm)
shows
high
sensitivity
viscosity/polarity
deep
channel
≈
750
nm).
Furthermore,
only
monitors
mitochondrial
polarity,
fluctuations
endogenous/exogenous
levels
but
also
distinguishes
cells
from
normal
multiple
parameters.
Additionally,
VPH-5DF
can
be
employed
monitor
alterations
levels,
as
well
during
drug-induced
pyroptosis
living
cells.
After
treatment
with
chemotherapy-induced
oxidative
damage
mitochondria
activated
pathway,
leading
robust
antitumor
response,
evidenced
xenograft
models.
Thus,
this
prodrug
offers
new
platform
vivo
diagnosis
anticancer
chemotherapy.
