Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216480 - 216480
Published: Feb. 5, 2025
Language: Английский
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging
Language: Английский
Citations
3
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 2, 2024
Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.
Language: Английский
Citations
10
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
10
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134275 - 134275
Published: April 10, 2024
Language: Английский
Citations
9
Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112734 - 112734
Published: Jan. 10, 2025
Language: Английский
Citations
1
Talanta, Journal Year: 2025, Volume and Issue: 286, P. 127570 - 127570
Published: Jan. 10, 2025
Language: Английский
Citations
1
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Masked cryptic kidney injury (MCKI), an early stage of acute (AKI), is challenging to detect and diagnose, especially in the modern context where toxic substances, such as surfactants, are increasingly misused. Consequently, there urgent need for methods visual diagnosis MCKI. In this study, we synthesized environmentally friendly spirulina-derived carbon dots (SpiCDs) using spirulina a biobased raw material through simple hydrothermal process. These SpiCDs, with their ultrasmall size, enable efficient renal clearance. cellular experiments, SpiCDs rapidly entered SDS-damaged cells, facilitating dynamic monitoring cell membrane damage vivo animal experiments demonstrated that were efficiently excreted kidneys began accumulate bladder within 10 min after tail vein injection. The detection red fluorescence urine confirmed metabolic pathway SpiCDs. Furthermore, MCKI model induced by SDS, showed accelerated excretion earlier accumulation bladder, indicating increased sensitivity injury. results suggest provide promising approach MCKI, offering insights into its monitoring.
Language: Английский
Citations
1
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216495 - 216495
Published: Feb. 5, 2025
Language: Английский
Citations
1
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.
Language: Английский
Citations
1
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2548 - 2558
Published: May 24, 2024
Chemotherapy faces critical challenges in clinical oncology treatment. One primary reason is the tumor hypoxia that obstructs penetration of chemotherapeutic drugs into solid tumors and diminishes drug concentration cells, leading to suboptimal treatment outcomes. Thereupon, we create a self-immolative phototherapeutic prodrug (DHQ-AZO-BIO) featured with targeting activation. First, heavy-atom-free photosensitizer based on intramolecular noncovalent interactions (NCIs), which specifically enriches produces photocytotoxic 1O2 eliminate normoxic cells surface layer by photodynamic therapy (PDT). Second, PDT process also increases hypoxic degree within tumor, thereby improving on-demand release action efficiency hypoxia-sensitive prodrug. This combined fashion synergizes hypoxia-activated chemotherapy overcome limitation augment therapeutic index for tumors, contributing development delivery systems (DDSs) precise phototherapy tumors.
Language: Английский
Citations
7