Luciferase-Decorated Gold Nanorods as Dual-Modal Contrast Agents for Tumor-Targeted High-Performance Bioluminescence/Photoacoustic Imaging DOI
Jingyu Zhang,

Bin Guo,

Yiyi Jiang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(22), P. 9132 - 9140

Published: May 20, 2024

Gold nanorods (AuNRs) have been considered highly compelling materials for early cancer diagnosis and aroused a burgeoning fascination among the biomedical sectors. By leveraging versatile tunable optical properties of AuNRs, herein, we developed novel tumor-targeted dual-modal nanoprobe (FFA) that exhibits excellent bioluminescence photoacoustic imaging performance tumor diagnosis. FFA has synthesized by anchoring recombinant bioluminescent firefly luciferase protein (Fluc) on folate-conjugated AuNRs via PEG linker. TEM images UV-vis studies confirm nanorod morphology successful conjugation biomolecules to AuNRs. The relies ability folate module target receptor-positive cells actively, simultaneously, Fluc facilitates in physiological conditions. success chemical engineering present study enables stronger signals (Skov3, Hela, MCF-7) than receptor-negative (A549, 293T, MCF-10A, HepG2). Additionally, induced strong conversion performance, enhancing resolution imaging. No apparent toxicity was detected at cellular mouse tissue levels, manifesting biocompatibility nature nanoprobe. Prompted positive merits FFA, vivo animal were performed, notable enhancement observed bioluminescent/photoacoustic intensity region compared folate-blocking region. Therefore, this synergistic platform holds great potential as contrast agent with high-performance information.

Language: Английский

Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

106
Biomarker-driven molecular imaging probes in radiotherapy DOI Creative Commons
Haonan Li, Qiyong Gong, Kui Luo

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146

Published: Jan. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Language: Английский

Citations

80
Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy DOI

Peizheng Xiong,

Xiaodan Wei, Li Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 20, 2024

Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.

Language: Английский

Citations

24
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

20
Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments DOI
Xiaomin Liu, Mingkun Wang, Yichao Jiang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(24), P. 24854 - 24866

Published: Dec. 4, 2023

Macrophages play a crucial role in immune activation and provide great value the prognosis of cancer treatments. Current strategies for prognostic evaluation macrophages mainly target specific biomarkers to reveal number distribution tumors, whereas phenotypic change M1 M2 situ is less understood. Here, we designed an ultrasmall superparamagnetic iron oxide nanoparticle-based molecular imaging nanoprobe quantify repolarization by magnetic resonance (MRI) using redox-active nitric (NO) as vivid chemical target. The equipped with O-phenylenediamine groups could react intracellular NO molecules during phenotype, leading electrical attraction colloidal aggregation nanoprobes. Consequently, prominent changes T1 T2 relaxation MRI allow quantification macrophage polarization. In 4T1 breast model, was able polarization predict treatment efficiency both immunotherapy radiotherapy paradigms. This study presents noninvasive approach monitor providing insight into treatments regarding macrophage-mediated responses.

Language: Английский

Citations

25
One Stone, Three Birds: Design and Synthesis of “All-in-One” Nanoscale Mn-Porphyrin Coordination Polymers for Magnetic Resonance Imaging-Guided Synergistic Photodynamic-Sonodynamic Therapy DOI
Peng Geng, Yan Li, Daniel K. Macharia

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 660, P. 1021 - 1029

Published: Jan. 24, 2024

Language: Английский

Citations

16
Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo DOI Creative Commons
Tian Zhang,

Han Yin,

Li Yu

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109804 - 109804

Published: April 23, 2024

Nucleic acid therapeutics offer tremendous promise for addressing a wide range of common public health conditions. However, the

Language: Английский

Citations

14
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

12
Imaging-guided Companion Theranostics: Ushering in A New Era of Personalized Cancer Care DOI Creative Commons
Meng Li, Yumeng Wu, Jing Lin

et al.

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity DOI
Lanlan Chen, Jingjing Lai, Siqi Dong

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: 97(1), P. 382 - 391

Published: Jan. 2, 2025

Evaluating tumor radiosensitivity is beneficial for the prediction of treatment efficacy, customization plans, and minimization side effects. Tracking mitochondrial DNA (mtDNA) repair process helps to assess as mtDNA determines fate cell under radiation-induced damage. However, current probes developed monitor levels enzymes suffered from complex synthesis, uncontrollable preparation, limited selectivity, poor organelle-targeting ability. Especially, correlation between activity inherent tumors has not yet been explored. Here, we present a mitochondria-targeted DNA-based nanoprobe (TPP-Apt-tFNA) in situ monitoring enzyme evaluating radiosensitivity. TPP-Apt-tFNA consists tetrahedral framework precisely modified with three functional modules on each vertexes, that is, cell-targeting aptamer, mitochondrion-targeting moiety, apurinic/apyrimidinic endonuclease 1 (APE1)-responsive molecule beacon. Once selectively internalized by cells, targeted mitochondrion specifically recognized APE1 activate fluorescence, allowing observation activity. The showed elevated mitochondria cells oxidative stress. Moreover, enabled illumination different APE1-mediated cycle phases. Furthermore, using vitro vivo, found high repair, which allowed them recover lesions, had low sensitivity radiation an unsatisfactory radiotherapy outcome. Our work provides new imaging tool exploring roles diverse biological processes guiding treatment.

Language: Английский

Citations

1