Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
With
the
construction
and
operational
launch
of
third‐generation
synchrotron
radiation
sources,
X‐ray
molecular
probe
technology
is
actively
explored
developed,
playing
an
increasingly
significant
role
in
modern
life
sciences.
This
review
provides
overview
synchrotron‐based
imaging
techniques
emphasizes
applications
probes
across
various
fields
associated
with
intelligent
biomedicine.
Building
on
this
foundation,
it
further
discusses
future
advancements
forecasts
their
application
trends
biomedicine,
particularly
realm
personalized
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(10), P. 4127 - 4146
Published: Jan. 1, 2024
Biomarker-driven
molecular
imaging
has
emerged
as
an
integral
part
of
cancer
precision
radiotherapy.
The
use
probes,
including
nanoprobes,
have
been
explored
in
radiotherapy
to
precisely
and
noninvasively
monitor
spatiotemporal
distribution
biomarkers,
potentially
revealing
tumor-killing
mechanisms
therapy-induced
adverse
effects
during
radiation
treatment.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 20, 2024
Abstract
Mild
photothermal
therapy
(PTT)
is
an
emerging
and
elegant
approach
with
minimal
adverse
effects,
demonstrating
itself
as
effective
treatment
for
cancer.
However,
potential
challenges
may
arise
from
the
overexpression
of
heat
shock
protein
90
(HSP90)
reliance
on
monotherapy.
Here,
a
near‐infrared
(NIR)
light‐triggered
MXene
nanocomposite
(FA@MXene/CuO
2
/GA)
developed
to
synergistically
combine
mild
PTT
chemodynamic
(CDT)
remarkably
tumor
eradication
without
any
notable
tissue
damage.
Under
irradiation
NIR
light,
effectively
enhances
by
suppressing
HSP90
expression
through
release
gambogic
acid
(GA)
due
excellent
performance
Ti
3
C
nanosheets
well
tumor‐targeting
ability
biocompatibility
surface‐modified
FA‐PEG‐SH.
The
copper‐based
catalyst
CuO
in
this
system
releases
Cu
2+
acid‐triggered
manner
within
microenvironment,
activating
Fenton‐like
reaction
generate
hydroxyl
radicals,
simultaneous
production
H
O
serves
alleviate
deficiency
endogenous
tumor.
Overall,
current
work
showcases
remarkable
synergistic
anticancer
effect
CDT,
also
proposes
new
avenues
research
utilizing
nanomaterials
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(24), P. 24854 - 24866
Published: Dec. 4, 2023
Macrophages
play
a
crucial
role
in
immune
activation
and
provide
great
value
the
prognosis
of
cancer
treatments.
Current
strategies
for
prognostic
evaluation
macrophages
mainly
target
specific
biomarkers
to
reveal
number
distribution
tumors,
whereas
phenotypic
change
M1
M2
situ
is
less
understood.
Here,
we
designed
an
ultrasmall
superparamagnetic
iron
oxide
nanoparticle-based
molecular
imaging
nanoprobe
quantify
repolarization
by
magnetic
resonance
(MRI)
using
redox-active
nitric
(NO)
as
vivid
chemical
target.
The
equipped
with
O-phenylenediamine
groups
could
react
intracellular
NO
molecules
during
phenotype,
leading
electrical
attraction
colloidal
aggregation
nanoprobes.
Consequently,
prominent
changes
T1
T2
relaxation
MRI
allow
quantification
macrophage
polarization.
In
4T1
breast
model,
was
able
polarization
predict
treatment
efficiency
both
immunotherapy
radiotherapy
paradigms.
This
study
presents
noninvasive
approach
monitor
providing
insight
into
treatments
regarding
macrophage-mediated
responses.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
97(1), P. 382 - 391
Published: Jan. 2, 2025
Evaluating
tumor
radiosensitivity
is
beneficial
for
the
prediction
of
treatment
efficacy,
customization
plans,
and
minimization
side
effects.
Tracking
mitochondrial
DNA
(mtDNA)
repair
process
helps
to
assess
as
mtDNA
determines
fate
cell
under
radiation-induced
damage.
However,
current
probes
developed
monitor
levels
enzymes
suffered
from
complex
synthesis,
uncontrollable
preparation,
limited
selectivity,
poor
organelle-targeting
ability.
Especially,
correlation
between
activity
inherent
tumors
has
not
yet
been
explored.
Here,
we
present
a
mitochondria-targeted
DNA-based
nanoprobe
(TPP-Apt-tFNA)
in
situ
monitoring
enzyme
evaluating
radiosensitivity.
TPP-Apt-tFNA
consists
tetrahedral
framework
precisely
modified
with
three
functional
modules
on
each
vertexes,
that
is,
cell-targeting
aptamer,
mitochondrion-targeting
moiety,
apurinic/apyrimidinic
endonuclease
1
(APE1)-responsive
molecule
beacon.
Once
selectively
internalized
by
cells,
targeted
mitochondrion
specifically
recognized
APE1
activate
fluorescence,
allowing
observation
activity.
The
showed
elevated
mitochondria
cells
oxidative
stress.
Moreover,
enabled
illumination
different
APE1-mediated
cycle
phases.
Furthermore,
using
vitro
vivo,
found
high
repair,
which
allowed
them
recover
lesions,
had
low
sensitivity
radiation
an
unsatisfactory
radiotherapy
outcome.
Our
work
provides
new
imaging
tool
exploring
roles
diverse
biological
processes
guiding
treatment.
