International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135353 - 135353
Published: Sept. 7, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Nov. 24, 2023
Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.
Language: Английский
Citations
119
Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 7
Published: March 18, 2025
Despite significant advancements in pharmaceutical sciences, conventional drug delivery system remains limited by issues like poor permeability, toxicity, suboptimal efficacy, and inadequate targeting. These challenges pose substantial barrier to effective treatment for complex conditions cancer, heart problems, chronic pain management, etc. Mesoporous silica nanoparticle (MSN), with their remarkable structural tunability multifunctionality, have emerged as a transformative solution the realm of system. This review delves into state-of-the-art synthesis methods MSNs including physical, chemical, top down bottom-up approaches particular attention widely used Sol-Gel process. We also explore innovative loading strategies controlled release mechanisms, underscoring how factors such pore size, particle shape, surface charge influence therapeutic outcomes. Furthermore, we highlight burgeoning applications across multiple domains, ranging from anticancer therapy gene emerging fields precision agriculture environmental remediation. Recent studies demonstrate versatility addressing both biomedical ecological challenges, making them an indispensable tool modern science. By synthesizing Collectively, this aims provide comprehensive resource researchers practitioners, fostering continued innovation design application MSN-based nanotechnology.
Language: Английский
Citations
2
Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1088 - 1112
Published: Jan. 29, 2024
Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as promising approach for counteracting evasive tactics of cancer cells. This study delves into innovative realm stimuli-responsive polymeric nanomedicines in context immunotherapy. By capitalizing on intricate landscape tumor microenvironment (TME), which orchestrates suppression and progression, offer tailored strategy enhance therapeutic interventions. The aberrant features TME, include factors such low pH, inflammation, oxidative stress, enzyme overexpression, serve triggers intelligent delivery systems facilitated by functional polymers. dynamic potential overcome challenges faced traditional nanoparticle-based immunotherapy techniques, presenting platform precisely optimize drug within locale. As synergistic interaction between TME unfolds, novel horizon emerges advance efficacy while mitigating its associated limitations.
Language: Английский
Citations
8
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116546 - 116546
Published: April 10, 2024
Nanomaterials possess unusual physicochemical properties including unique optical, magnetic, electronic properties, and large surface-to-volume ratio. However, nanomaterials face some challenges when they were applied in the field of biomedicine. For example, suffer from limitations such as poor selectivity biocompatibility, low stability, solubility. To address above-mentioned obstacles, functional nucleic acid has been widely served a powerful versatile ligand for modifying because their characteristics, ease modification, excellent high predictable intermolecular interaction recognition ability. The functionally integrating with produced various kinds nanocomposites recent advances applications decorated cancer imaging therapy summarized this review. Further, we offer an insight into future perspectives nanomaterials.
Language: Английский
Citations
6
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216117 - 216117
Published: July 27, 2024
Language: Английский
Citations
6
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(8), P. 4991 - 5007
Published: Aug. 1, 2024
The GPS-Nanoconveyor (MA-NV@DOX-Cas13a) is a targeted nanoplatform designed for the imaging and gene/chemotherapy synergistic treatment of melanoma. It utilizes rolling circle amplification (RCA) products as scaffold to construct DNA "Nanoconveyor" (NV), which incorporates multivalent aptamer (MA) "GPS", encapsulates doxorubicin (DOX) in transporter, equips it with CRISPR/Cas13a ribonucleoproteins (Cas13a RNP). Carrying MA enhances ability recognize overexpressed receptor nucleolin on B16 cells, enabling precise delivery MA-NV@DOX-Cas13a through receptor-mediated endocytosis. activation signal transducer activator transcription 3 (STAT3) cancer cells triggers cis-cleavage CRISPR/Cas13a, initiating its trans-cleavage function. Additionally, deoxyribonuclease I (DNase I) degrades MA-NV, releasing DOX intracellular chemotherapeutic agent. Experiments demonstrate superior capabilities this versatile cellular co-treatment while highlighting advantages these nanodrug systems mitigating side effects.
Language: Английский
Citations
5
The Innovation Materials, Journal Year: 2024, Volume and Issue: 2(2), P. 100064 - 100064
Published: Jan. 1, 2024
<p>With the rapid development of DNA nanotechnology, emergence fluorescent nanostructures (FDNs) has enlarged biological applications. FDNs have great advantages precise localization and real-time tracing in bioimaging. In this review, recent biomedical developments been reviewed, including design FDNs, corresponding applications on biomarker sensing, bioimaging, cancer diagnosis therapy. Firstly, DNA-based nanomaterials were briefly introduced. Simultaneously, to make a better demonstration, background theory fluorescence detections Thereafter, synthetic strategies nanostructure summarized classified, which facilitated multiple functionalizations for sensing Subsequently, are comprehensively based different detection strategies, resonance energy transfer (FRET), nucleic acid amplification (NAT), aggregation-induced emission (AIE), near-infrared (NIR)-photoactivation, small dyes loading, surface plasmon (SPR) technologies. Finally, an insight into challenges future perspectives is provided. As important tools precision medicine, showing potential both <i>in vivo</i> vitro</i> treatments. Undoubtedly, FDN-based technology promising strategy constructing versatile nanodevices will excel human healthcare.</p>
Language: Английский
Citations
4
ACS Polymers Au, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Apart from the visual effects, geometric shapes of materials play an important role in their engineering and biomedical applications. Responsive materials-based patient-specific anatomical models provide better insights into structure pathology. Polymers are by far most utilized class for advanced science technology. Because these properties, polymers have been used as functional coatings, thermoplastics, materials, separators, binders Li-ion batteries, fuel cell membranes, piezoelectric devices, high-quality wires cables, so on. Reactive to stimuli because unusual electrical characteristics adaptability, stimuli-responsive multiacceptor conjugated a prominent focus study. These combine several electron-accepting units inside backbone, resulting increased functionality responsiveness variety stimuli. The production, workings, wide range applications this review.
Language: Английский
Citations
0
Semiconductors, Journal Year: 2025, Volume and Issue: 59(2), P. 183 - 189
Published: Feb. 1, 2025
Language: Английский
Citations
0
Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Abstract Interfacial molecular engineering of rare earth‐doped nanocrystals (RE NCs) by incorporating surface organic emitters is receiving widespread attention in the area functional nanomaterials. The resulting organic–inorganic nanoconjugates are able to integrate individual strengths and show exciting optical/electrical/magnetic functionalities. However, there a shortage systematic reviews reporting most recent progress interfacial RE NCs. Thereby, this review presents comprehensive timely perspective on advances crucial theoretical knowledge first summarized, ranging from luminescence mechanism molecules/RE NCs energy transfer mechanisms at interface. Construction protocols for coupling molecules then discussed, including chemical coordination physical adsorption pathways. In particular, beyond traditional bio‐imaging/therapy, advanced applications enabled interface outlined, not limited photoexcited 3D printing, light‐induced photochromism/deformation, micro‐modification, dynamic procedure regulation. Finally, challenges perspectives presented accelerate future provide research guidance This provides deeper broader understanding NC pushes technology closer practical applications.
Language: Английский
Citations
0