Biodegradable FePS 3 nanoplatform for efficient treatment of osteosarcoma by combination of gene and NIR-II photothermal therapy DOI Creative Commons
Tingting Luo, Mingyang Jiang, Ziqiang Cheng

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 28, 2023

Abstract Background As a common tumor with high incidence, osteosarcoma possesses extremely poor prognosis and mortality. Improving the survival of patients is still great challenge due to precipice advancement in treatment. This study aims develop multifunctional nanoplatform based on synergistic effect NIR-II photothermal therapy (PTT) gene for efficient treatment osteosarcoma. Methods In this study, combination strategy developed Two-dimensional (2D) FePS 3 nanosheets are synthesized functionalized by poly-L-lysine-PEG-folic acid (PPF) fabricate (FePS@PPF) further loading microRNAs inhibitor, miR-19a inhibitor (anti-miR-19a). Results The conversion efficiency FePS@PPF up 47.1% under irradiation 1064 nm laser. vitro shows that anti-miR-19a can be efficiently internalized into cells through protection delivery nanao carrier, which induces up-regulation PTEN down-regulation p-AKT gene. After intravenous injection, specifically accumulates site osteosarcoma-bearing mice. vivo investigations reveal combined PTT-gene displays most significant ablation compared monotherapy. More importantly, good biodegradability promotes cleared from body avoiding potential toxicity long-term retention. Conclusion Our work not only develops PTT mediated anti-miR-19a/FePS@PPF but also provides insights design applications other nanotherapeutic platforms.

Language: Английский

Achieving Clearance of Drug‐Resistant Bacterial Infection and Rapid Cutaneous Wound Regeneration Using an ROS‐Balancing‐Engineered Heterojunction DOI

Chong Geng,

Shuai He, Sheng Yu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Feb. 1, 2024

Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene bio‐heterojunctions (2D ‐bioHJs) devised. Under ultrasonication, 2D ‐bioHJs effectively eliminate disrupting metabolism electron transport chain (ETC). When ultrasonication ceases, they enable elimination SPT‐generated ROS. The act as a “lever” that achieves balance between ROS generation annihilation, delivering both antibacterial anti‐inflammatory properties engineered membrane. More importantly, in vivo assays corroborate membranes transform stalled chronic environment into regenerative one eradicating bacterial population, dampening NF‐κB pathway promoting angiogenesis. As envisaged, this work demonstrates novel tactic arm with programmed effects remedy refractory wounds from drug‐fast bacteria.

Language: Английский

Citations

59
Nb2CTx-Based MXenes Most Recent Developments: From Principles to New Applications DOI Creative Commons
Tholkappiyan Ramachandran, Abdel‐Hamid I. Mourad, Mostafa S. A. ElSayed

et al.

Energies, Journal Year: 2023, Volume and Issue: 16(8), P. 3520 - 3520

Published: April 18, 2023

MXenes are progressively evolving two-dimensional (2D) materials with an expanding wide range of applications in the field energy storage. They rank among best electrode for cutting-edge storage systems. Energy device performance is greatly enhanced by and their composite materials. As technology has improved over last several decades, demand high-capacity devices that versatile, sturdy, have cheap production costs increased. MXene, which based on Nb2CTx, most current material to emerge applications. Nb2CTx MXene now sought-after 2D family due its flexibility, high conductivity, superior electrochemical nature, hydrophilicity, tunable surface functional groups, great mechanical properties, layered structure. Examples include gas biosensors, water splitting, purification, antimicrobial coatings, electromagnetic interference shielding, transparent electrical conductors. Because distinctive properties scientists working further theoretical experimental enhancements. The objective this work deliver outline breakthroughs construction robust, flexible, highly effective powered supercapacitors. Deep research been conducted structure as well different synthesis techniques properties. emphasis also placed how various aspects, such architecture design, electrolyte composition, so on, influence charge efficiency MXene-based This article discusses recent advancements composite-based

Language: Английский

Citations

51
Scope, evaluation and current perspectives of MXene synthesis strategies for state of the art applications DOI
Muhammad Zeeshan Abid, Khezina Rafiq,

Anam Aslam

et al.

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(13), P. 7351 - 7395

Published: Jan. 1, 2024

This review provides insights into MXene synthesis methods, mechanisms, terminations, modifications strategies and important applications. Additionally, the advantages, drawbacks, suggestions, precautions have been discussed.

Language: Английский

Citations

43
MXene‐Based Functional Platforms for Tumor Therapy DOI
Fan Gao, Chun Xue, Tian Zhang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: May 5, 2023

Abstract Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly construction functional platforms for optimal antitumor therapy due to their high specific surface area, tunable performance, strong absorption near‐infrared light as well preferable plasmon resonance effect. In this review, progress MXene‐mediated is summarized after appropriate modifications or integration procedures. The enhanced treatments directly performed by MXenes, significant improving effect MXenes on different therapies, imaging‐guided strategies are discussed detail. Moreover, existing challenges future development directions presented.

Language: Английский

Citations

41
Recent advances in the use of MXenes for photoelectrochemical sensors DOI Creative Commons
Adriel Yan Sheng Tan,

Hafiz Taimoor Ahmed Awan,

Faliang Cheng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148774 - 148774

Published: Jan. 17, 2024

MXene is a newly discovered 2D carbon-based material that predominantly conductive. The most common MXene, titanium carbide (Ti3C2), can be used as conductive to enhance the photocurrent generated by photoelectrochemical (PEC) sensors. In order produce sheets are of high quality for PEC sensors and other light-based applications, it imperative synthesis methods production continue improved an extensive understanding its properties gained. Several fluorinated non-fluorinated from MAX discussed in this review. Detailed description mechanical, optical, topological, electronic, electrochemical resultant MXenes also presented. A critical analysis density functional theory (DFT) data pure well changes optical bandgap when doped with heteroatoms form heterojunctions or ternary nanocomposites, extensively described. Additionally, systematic exposition done on current MXene-based sensors, highlighting parameters yield performing sensor. review concludes opinion future direction sensing field.

Language: Английский

Citations

36
Engineering of Schottky heterojunction in Ru@Bi2S3/Nb2C MXene based on work function with enhanced carrier separation for promoted sterilization DOI

Jiafeng Xi,

Xiaojuan Liu,

Liang Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 473, P. 145169 - 145169

Published: Aug. 3, 2023

Language: Английский

Citations

32
Defect-rich platinum–zinc oxide heterojunction as a potent ROS amplifier for synergistic sono-catalytic therapy DOI Open Access
Yuxuan Li, Wenxin Li,

Yian Liu

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 171, P. 543 - 552

Published: Sept. 21, 2023

Language: Английский

Citations

22
Application and progress of nanozymes in antitumor therapy DOI Creative Commons

Gaihua He,

Chao Mei,

Chenbo Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130960 - 130960

Published: March 20, 2024

Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.

Language: Английский

Citations

13
MXenes in healthcare: synthesis, fundamentals and applications DOI Creative Commons
Zaheer Ud Din Babar, Vincenzo Iannotti, Giulio Rosati

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Since their discovery over a decade ago, MXenes have transformed the field of "materials for healthcare", stimulating growing interest in healthcare-related applications. These developments also driven significant advancements MXenes' synthesis. This review systematically examines synthesis and applications sensing biomedical fields, underscoring pivotal role addressing critical challenges modern healthcare. We describe experimental by combining appropriate laboratory modules with mechanistic principles underlying each step. In addition, we provide extensive details on parameters, considerations, essential instructions successful Various healthcare including sensing, imaging, synergistic therapies, regenerative medicine, wearable devices been explored. further highlight emerging trends MXenes, viz., as nanovehicles drug delivery, vectors gene therapy, tools immune profiling. By identifying important parameters that define utility applications, this outlines strategies to regulate profile, thereby serving valuable guide design application-specific properties. The final section integrates research theoretical studies comprehensive understanding field. It technologies, such artificial intelligence (AI) machine learning (ML), accelerating material discovery, structure-property optimization, automation. Complemented detailed supplementary information synthesis, stability, biocompatibility, environmental impact, insights, offers profound knowledge base diverse family 2D materials. Finally, compared potential other materials underscore existing prioritize interdisciplinary collaboration. synthesizing key from its current (especially 2018 onward), provides cohesive assessment MXene foundations prospects sector.

Language: Английский

Citations

1
MXene‐Mediated Catalytic Redox Reactions for Biomedical Applications DOI
Chenyao Wu, Lili Xia, Wei Feng

et al.

ChemPlusChem, Journal Year: 2024, Volume and Issue: 89(6)

Published: Feb. 15, 2024

Reactive oxygen species (ROS) play a crucial role in orchestrating myriad of physiological processes within living systems. With the advent materdicine, an array nanomaterials has been intricately engineered to influence redox equilibrium biological milieus, thereby pioneering distinctive therapeutic paradigm predicated on ROS-centric biochemistry. Among these, two-dimensional carbides, nitrides, and carbonitrides, collectively known as MXenes, stand out due their multi-valent multi-elemental compositions, large surface area, high conductivity, pronounced local plasmon resonance effects, positioning them prominent contributors ROS modulation. This review aims provide overview advancements harnessing MXenes for catalytic reactions various applications, including tumor, anti-infective, anti-inflammatory therapies. The emphasis lies elucidating mechanism involving both pro-oxidation anti-oxidation processes, underscoring redox-related applications facilitated by self-catalysis, photo-excitation, sono-excitation properties MXenes. Furthermore, this highlights existing challenges outlines future development trends leveraging ROS-involving disease treatments, marking significant step towards integration these into clinical practice.

Language: Английский

Citations

6