Enhancing the properties of soy protein isolate and dialdehyde starch films for food packaging applications through tannic acid crosslinking

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121903 - 121903

Published: Feb. 3, 2024

Language: Английский

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A Library of Polyphenol‐Amino Acid Condensates for High‐Throughput Continuous Flow Production of Nanomedicines with Ultra‐High Drug Loading

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Synthesizing high drug‐loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large‐scale engineered production of such presents even greater difficulties. This study scalable library polyphenol‐amino acid condensates. By selecting amino acids, the enables precise customization key properties, as carrier capacity, bioactivity, other critical attributes, offering versatile range options for various application scenarios. Leveraging properties solvent‐mediated disassembly reassembly condensates achieved an ultra‐high drug loading 86% paclitaxel. For poorly soluble molecules, capacity exceeded 50%, indicating broad applicability. Furthermore, employing continuous microfluidic device, rate can reach 5 mL min −1 (36 g per day), with nanoparticle size precisely tunable polydispersity index (PDI) below 0.2. The polyphenol‐based demonstrates efficient cellular uptake and, in three distinct animal models, has been shown to enhance therapeutic efficacy paclitaxel without significant side effects. streamlined, efficient, approach using microfluidics produce loading, promising strategy nanoformulation drugs.

Language: Английский

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Ecosafe-design of carboxymethyl cellulose encapsulated polyphenolic bio-nanocomposite valorized for sustainable industrial textile dye removal

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: 13(1), P. 115321 - 115321

Published: Jan. 5, 2025

Language: Английский

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Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150

Published: March 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Language: Английский

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Fabrication of an antibacterial system of arginine-modified chitosan with AgNPs-loaded montmorillonite for food preservation

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 156, P. 110258 - 110258

Published: June 6, 2024

Language: Английский

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Mussel-inspired self-healing adhesive MXene hydrogel for epidermal electronics

Device, Journal Year: 2024, Volume and Issue: 2(3), P. 100253 - 100253

Published: Feb. 29, 2024

Language: Английский

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EGCG-Modified Bioactive Core–Shell Fibers Modulate Oxidative Stress to Synergistically Promote Vascularized Bone Regeneration

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: 11(1), P. 543 - 555

Published: Jan. 2, 2025

Oxidative stress induced by reactive oxygen species (ROS) can adversely affect tissue repair, whereas endowing biomaterials with antioxidant activity improve the in vivo microenvironment, thereby promoting angiogenesis and osteogenesis. Accordingly, this study utilized epigallocatechin-3-gallate (EGCG), a material known for its reducing properties, oxidative self-polymerization capability, strong binding characteristics, to modify bioactive core–shell fibrous membrane (10RP-PG). Compared 10RP-PG membrane, EGCG-modified (E/10RP-PG) exhibited superior hydrophilicity, excellent cell adhesion, compatibility. Moreover, effectively scavenge free radicals, ameliorate local foster (enhancing expression of angiogenic genes human umbilical vein endothelial cells (HUVECs) 1.58 times vascular generation area upon subcutaneous implantation 4.47 times). The enhancement E/10RP-PG further promoted cartilage degeneration absorption, as well new bone formation, thus facilitating repair defects. This provides strategy defect through surface modification an agent, fabricated membranes show promise guiding vascularized regeneration.

Language: Английский

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Preparation of sodium alginate antibacterial porous composite pads embedded with centrifugally spun nanofibers by freeze-drying and recasting for active food packaging

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123430 - 123430

Published: Feb. 21, 2025

Language: Английский

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Food-packaging applications and mechanism of polysaccharides and polyphenols in multicomponent protein complex system: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132513 - 132513

Published: May 21, 2024

Language: Английский

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The synergistic effect of polyphenols and polypeptides for plant-based bioplastic film – Enhanced UV resistance, antioxidant and antibacterial performance

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140746 - 140746

Published: Aug. 3, 2024

Language: Английский

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