Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1321 - 1321
Published: July 4, 2022
Recent
studies
have
revealed
that
hydrogen
sulfide
(H2S)
increases
the
analgesic
actions
of
δ-opioid
receptor
(DOR)
in
inflammatory
pain.
However,
possible
improvement
analgesia
μ-opioid
(MOR)
and
DOR
agonists
during
neuropathic
pain,
through
pretreatment
with
two
slow-releasing
H2S
donors-DADS
(diallyl
disulfide)
GYY4137
(morpholin-4-ium
4-methoxyphenyl(morpholino)
phosphinodithioate
dichloromethane
complex)-is
still
unknown.
In
male
C57BL/6J
mice
pain
incited
by
chronic
constriction
sciatic
nerve
(CCI),
we
evaluated:
(1)
influence
DADS
(3.5
mg/kg)
(0.7
on
inhibition
allodynia
hyperalgesia
produced
systemic
or
local
administration
morphine
(3
mg/kg
65
µg)
UFP-512
(1
12.5
µg);
(2)
reversion
antinociceptive
high
doses
(30
(24
MOR
antagonists;
(3)
effects
donors
oxidative
stress,
apoptotic
responses,
expression
medial
septum
(MS)
dorsal
root
ganglia
(DRG).
The
results
both
improved
antiallodynic
UFP-512,
possibly
up-regulating
DRG.
antagonists
blocked
properties
GYY4137,
revealing
feasible
participation
endogenous
opioid
system
effects.
Moreover,
inhibited
stress
apoptosis
generated
CCI
MS
and/or
This
study
suggests
co-treatment
as
a
potential
therapy
for
Pharmacology & Therapeutics,
Journal Year:
2022,
Volume and Issue:
241, P. 108327 - 108327
Published: Dec. 5, 2022
The
composition
of
intestinal
microbiota
is
influenced
by
a
number
factors,
including
medications,
which
may
have
substantial
impact
on
host
physiology.
Nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
and
opioid
analgesics
are
among
those
widely
used
medications
that
been
shown
to
alter
in
both
animals
humans.
Although
much
effort
has
devoted
identify
signatures
associated
with
these
less
known
about
the
underlying
mechanisms.
Mucosal
inflammation,
changes
motility,
luminal
pH
bile
acid
metabolism,
or
direct
drug-induced
inhibitory
effect
bacterial
growth
all
potential
contributors
NSAID-
opioid-induced
dysbiosis,
however,
only
few
studies
addressed
directly
issues.
In
addition,
there
notable
overlap
between
certain
diseases
they
used,
such
as
spondyloarthritis
(SpA),
rheumatoid
arthritis
(RA)
neuropathic
pain
type
2
diabetes
(T2D).
aims
present
review
threefold.
First,
we
aim
provide
comprehensive
up-to-date
summary
alterations
caused
NSAIDs
opioids.
Second,
critically
available
data
possible
mechanisms
dysbiosis.
Third,
current
knowledge
gut
dysbiosis
SpA,
RA
T2D,
highlight
similarities
them
We
posit
contribute
persistence
diseases,
potentially
limit
therapeutic
long-term
use.
this
context,
will
literature
probiotic
supplementation
fecal
transplantation
efficacy
opioids
diseases.
Cell Metabolism,
Journal Year:
2023,
Volume and Issue:
35(9), P. 1548 - 1562.e7
Published: July 13, 2023
The
pathogenic
mechanisms
underlying
distal
symmetric
polyneuropathy
(DSPN),
a
common
neuropathy
in
patients
with
diabetes
mellitus
(DM),
are
not
fully
understood.
Here,
we
discover
that
the
gut
microbiota
from
DSPN
can
induce
phenotype
exhibiting
more
severe
peripheral
db/db
mice.
In
randomized,
double-blind,
and
placebo-controlled
trial
(ChiCTR1800017257),
compared
to
10
who
received
placebo,
was
significantly
alleviated
22
fecal
transplants
healthy
donors,
independent
of
glycemic
control.
bacterial
genomes
correlated
Toronto
Clinical
Scoring
System
(TCSS)
score
were
organized
two
competing
guilds.
Increased
guild
1,
which
had
higher
capacity
butyrate
production,
decreased
2,
harbored
genes
synthetic
pathway
endotoxin,
associated
improved
barrier
integrity
proinflammatory
cytokine
levels.
Moreover,
matched
enterotype
between
recipients
showed
better
therapeutic
efficacy
enriched
1
suppressed
2.
Thus,
changes
these
guilds
may
play
causative
role
have
potential
for
targeting.
Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: April 10, 2024
Chemotherapy-induced
peripheral
neuropathy
(CIPN)
is
the
most
common
off-target
adverse
effects
caused
by
various
chemotherapeutic
agents,
such
as
cisplatin,
oxaliplatin,
paclitaxel,
vincristine
and
bortezomib.
CIPN
characterized
a
substantial
loss
of
primary
afferent
sensory
axonal
fibers
leading
to
disturbances
in
patients.
An
estimated
19-85%
patients
developed
during
course
chemotherapy.
The
lack
preventive
measures
limited
treatment
options
often
require
dose
reduction
or
even
early
termination
life-saving
chemotherapy,
impacting
efficacy
patient
survival.
In
this
Review,
we
summarized
current
understanding
on
pathogenesis
CIPN.
One
prominent
change
induced
agents
involves
disruption
neuronal
cytoskeletal
architecture
transport
dynamics
largely
influenced
interference
microtubule
stability
neurons.
Due
an
ineffective
blood-nerve
barrier
our
nervous
system,
exposure
some
causes
mitochondrial
swelling
nerves,
which
lead
opening
permeability
transition
pore
cytochrome
c
release
resulting
degeneration
fibers.
exacerbated
nociceptive
signaling
pain
transmission
linked
increased
excitability
due
elevated
expression
ion
channels
dorsal
root
ganglion
Another
important
contributing
factor
neuroinflammation
infiltration
immune
cells
production
inflammatory
cytokines.
central
also
induce
hyperexcitability
spinal
horn
anterior
cingulate
cortex
development
sensitization
that
Emerging
evidence
suggests
composition
diversity
gut
microbiota
(dysbiosis)
could
have
direct
impact
progression
Collectively,
all
these
aspects
contribute
Recent
advances
RNA-sequencing
offer
solid
platform
for
Neurogastroenterology & Motility,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
ABSTRACT
Background
The
enteric
nervous
system
plays
a
key
role
in
the
coordination
of
gastrointestinal
motility
together
with
sympathetic,
parasympathetic,
and
extrinsic
sensory
pathways.
In
some
cases,
abnormalities
neural
activity
these
pathways
contribute
to
disorders
gut
motility.
Where
this
is
associated
damage
or
death
neurons,
usually
detected
by
microscopy,
considered
neuropathy.
Purpose
This
review
summarizes
recent
advances
identification
neuropathies
range
disorders.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(3), P. 748 - 748
Published: March 1, 2023
The
prevalence
of
neurological
conditions
which
manifest
with
chronic
pain
is
increasing
globally,
where
the
World
Health
Organisation
has
now
classified
as
a
risk
factor
for
death
by
suicide.
While
many
have
definitive
underlying
aetiology,
non-somatic
represent
difficult-to-diagnose
and
difficult-to-treat
public
health
issues.
interaction
immune
system
nervous
become
an
important
area
in
understanding
occurrence
neuroinflammation,
nociception,
peripheral
central
sensitisation
seen
pain.
More
recently,
however,
role
resident
microbial
species
human
gastrointestinal
tract
evident.
Dysbiosis,
alteration
present
favour
non-beneficial
pathogenic
emerged
conditions,
including
functional
somatic
syndromes,
autoimmune
disease
diseases.
In
particular,
decreased
abundance
small
chain
fatty
acid,
e.g.,
butyrate-producing
bacteria,
Faecalibacterium,
Firmicutes
some
Bacteroides
spp.,
frequently
evident
morbidities
associated
long-term
Microbes
involved
production
neurotransmitters
serotonin,
GABA,
glutamate
dopamine,
mediate
gut-brain,
axis
are
also
important.
This
review
outlines
dysbiosis
states
manifesting
pain,
overlap
patients.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8061 - 8061
Published: April 29, 2023
It
has
been
widely
demonstrated
that
the
gut
microbiota
is
responsible
for
essential
functions
in
human
health
and
its
perturbation
implicated
development
progression
of
a
growing
list
diseases.
The
number
studies
evaluating
how
interacts
with
influences
other
organs
systems
body
vice
versa
constantly
increasing
several
‘gut–organ
axes’
have
already
defined.
Recently,
view
on
link
between
(GM)
peripheral
nervous
system
(PNS)
become
broader
by
exceeding
fact
PNS
can
serve
as
systemic
carrier
GM-derived
metabolites
products
to
organs.
communication
network
central
periphery
internal
rather
be
affected
itself
GM
perturbation.
In
this
review,
we
summarize
current
knowledge
about
impact
PNS,
regard
somatic
autonomic
divisions,
physiological,
regenerative
pathological
conditions.
Pakistan Veterinary Journal,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 1, 2023
Peripheral
nerve
injury
(PNI)
is
among
the
leading
health
issues
affecting
modern
era.Currently,
there
are
no
effective
therapeutic
strategies
to
heal
damage
and
ensure
fully
functional
recovery.Probiotics
can
serve
as
an
appealing
option
close
this
gap
via
gut
microbiota.The
purpose
of
study
was
evaluate
role
probiotics
on
recovery
after
injury.For
purpose,
sixty
healthy
BALB/c
mice
were
divided
into
04-groups.The
control
group
given
a
routine
diet.In
contrast,
positive
control,
pre-injury
post-injury
administrated
their
respective
treatments
orally
from
day
end
project.The
sciatic
index,
grip
strength,
pinprick,
hot
plate
tests
used
analyse
retrieval
motor
sensory
functions,
results
for
highly
significant.Additionally,
fiber
count
surface
area
Tibialis
anterior
muscle
significantly
improved
in
group.When
compared
groups,
group's
much
lower
total
oxidant
status
increased
antioxidant
capacity
indicate
that
have
strong
potential
improve
restoration
function
when
introduced
before
injury.These
imply
able
accelerate
following
peripheral
gut-brain
axis.Nonetheless,
future
studies
warranted
identify
underlying
mechanism
boosts
restoration.
