Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 20, 2023
Intraepidermal
nerve
fiber
density
(IENFD)
has
become
an
important
biomarker
for
neuropathy
diagnosis
and
research.
The
consequences
of
reduced
IENFD
can
include
sensory
dysfunction,
pain,
a
significant
decrease
in
quality
life.
We
examined
the
extent
to
which
is
being
used
as
tool
human
mouse
models
compared
degree
loss
between
diseases
gain
broader
understanding
existing
data
collected
using
this
common
technique.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 28, 2024
The
cornea
is
the
outermost
layer
of
eye
and
plays
an
essential
role
in
our
visual
system.
Limbal
epithelial
stem
cells
(LESCs),
which
are
localized
to
a
highly
regulated
limbal
niche,
master
conductors
corneal
regeneration.
Damage
LESCs
their
niche
may
result
cell
deficiency
(LSCD),
disease
confused
ophthalmologists
so
many
years
can
lead
conjunctivalization,
neovascularization,
even
blindness.
How
restore
function
hot
topic
for
ocular
scientists
clinicians
around
world.
This
review
introduced
microenvironment,
outlined
various
techniques
isolating
culturing
used
LSCD
research,
presented
common
diseases
that
cause
LSCD,
provided
comprehensive
overview
both
diagnosis
multiple
treatments
from
basic
research
clinical
therapies,
especially
emerging
therapies
based
on
sources.
In
addition,
we
also
innovatively
concluded
latest
strategies
recent
years,
including
exogenous
drugs,
tissue
engineering,
nanotechnology,
exosome
gene
therapy,
as
well
ongoing
trials
treating
five
years.
Finally,
highlighted
challenges
bench
bedside
discussed
cutting-edge
areas
therapeutic
research.
We
hope
this
could
pave
way
future
translation
crucial
step
field
health.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
Chemotherapy-induced
peripheral
neuropathy
(CIPN)
is
a
common
complication
that
affects
an
increasing
number
of
cancer
survivors.
However,
the
current
treatment
options
for
CIPN
are
limited.
Paclitaxel
(PTX)
widely
used
chemotherapeutic
drug
induces
senescence
in
cells.
While
previous
studies
have
demonstrated
Sonic
hedgehog
(Shh)
can
counteract
cellular
dysfunction
during
aging,
its
role
remains
unknown.
Herein,
aim
this
study
was
to
investigate
whether
Shh
activation
could
inhibits
neuronal/glial
and
alleviates
CIPN.
We
treated
ND7/23
neuronal
cells
RSC96
Schwann
with
two
selective
activators
(purmorphamine
[PUR]
smoothened
agonist
[SAG])
presence
PTX.
Additionally,
we
utilized
mouse
model
induced
by
PTX
injection.
To
assess
senescence,
performed
senescence-associated
β-galactosidase
(SA-β-gal)
assay,
measured
reactive
oxygen
species
(ROS)
levels,
examined
expression
P16,
P21,
γH2AX.
understand
underlying
mechanisms,
conducted
ubiquitin
assays,
LC-MS/MS,
H&E
staining,
assessed
protein
through
Western
blotting
immunofluorescence
staining.
In
vitro,
observed
significantly
alleviated
senescence-related
decline
multiple
functions
included
SA-β-gal
activity,
P16
cell
viability,
ROS
accumulation
DRG
sensory
neurons
after
exposure.
Furthermore,
our
vivo
experiments
reduced
axonal
degeneration,
demyelination,
improved
nerve
conduction.
Mechanistically,
discovered
level
SP1,
which
ubiquitinated
E3
ligase
TRIM25
at
lysine
694
(K694),
leading
increased
CXCL13
expression,
found
inhibited
PTX-induced
TRIM25-SP1-CXCL13
axis.
These
findings
provide
evidence
cells,
suggesting
be
potential
therapeutic
target
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: March 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 9, 2024
Rosacea
is
a
chronic
inflammatory
skin
disorder,
whose
underlying
cellular
and
molecular
mechanisms
remain
obscure.
Here,
we
generate
single-cell
atlas
of
facial
from
female
rosacea
patients
healthy
individuals.
Among
keratinocytes,
subpopulation
characterized
by
IFNγ-mediated
barrier
function
damage
found
to
be
unique
lesions.
Blocking
IFNγ
signaling
alleviates
rosacea-like
phenotypes
in
mice.
The
papulopustular
featured
expansion
pro-inflammatory
fibroblasts,
Schwann,
endothelial
macrophage/dendritic
cells.
frequencies
type
1/17
skin-resident
memory
T
cells
are
increased,
vascular
mural
activation
pathways
impaired
muscle
contraction
rosacea.
Most
importantly,
fibroblasts
identified
as
the
leading
cell
producing
vasodilative
signals
Depletion
or
knockdown
PTGDS,
gene
specifically
upregulated
blocks
development
Our
study
provides
comprehensive
understanding
aberrant
alterations
populations
identifies
key
determinant
development.
common
disorder
mainly
affecting
central
face.
individuals
reveals
changes
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 20, 2023
Intraepidermal
nerve
fiber
density
(IENFD)
has
become
an
important
biomarker
for
neuropathy
diagnosis
and
research.
The
consequences
of
reduced
IENFD
can
include
sensory
dysfunction,
pain,
a
significant
decrease
in
quality
life.
We
examined
the
extent
to
which
is
being
used
as
tool
human
mouse
models
compared
degree
loss
between
diseases
gain
broader
understanding
existing
data
collected
using
this
common
technique.
