Epilepsia,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 6, 2024
Abstract
Objective
Anterior
temporal
lobe
resection
(ATLR)
is
an
effective
treatment
for
drug‐resistant
epilepsy
(TLE),
although
language
deficits
may
occur
after
both
left
and
right
ATLR.
Functional
reorganization
of
the
network
has
been
observed
in
ipsilateral
contralateral
hemispheres
within
12
months
ATLR,
but
little
known
longer‐term
plasticity
effects.
Our
aim
was
to
examine
functions
up
a
decade
relation
cognitive
profiles.
Methods
We
examined
24
TLE
patients
(12
[LTLE])
10
controls
across
four
time
points:
pre‐surgery,
4
months,
~9
years
post‐ATLR.
Participants
underwent
standard
neuropsychological
assessments
(naming,
phonemic,
categorical
fluency
tests)
verbal
functional
magnetic
resonance
imaging
(fMRI)
task.
Using
flexible
factorial
design,
we
analyzed
longitudinal
fMRI
activations
from
post‐ATLR,
relative
controls,
with
separate
analyses
people
hippocampal
sclerosis
(HS).
Change
profiles
correlated
long‐term
change
determine
“efficiency”
reorganized
networks.
Results
LTLE
had
increased
engagement
extra‐temporal
regions,
better
performance
linked
bilateral
activation.
Those
HS
exhibited
more
widespread
activations.
RTLE
showed
outcomes
associated
these
areas.
Both
groups
achieved
stability
over
9
years,
than
50%
improving.
Older
age,
longer
duration,
lower
pre‐operative
reserve
negatively
affected
performance.
Significance
Neuroplasticity
continues
post‐epilepsy
surgery
RTLE,
recovery
regions.
This
adaptive
improved
outcomes,
challenging
traditional
view
localized
These
findings
emphasize
need
early
intervention,
tailored
counseling,
potential
continued
gains
extended
post‐ATLR
rehabilitation.
Epilepsia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
Abstract
The
cerebellum,
a
subcortical
structure,
is
traditionally
linked
to
sensorimotor
integration
and
coordination,
although
its
role
in
cognition
affective
behavior,
as
well
epilepsy,
increasingly
recognized.
Cerebellar
dysfunction
patients
with
epilepsy
can
result
from
genetic
disorders,
antiseizure
medications,
seizures,
seizure‐related
trauma.
Impaired
cerebellar
function,
regardless
of
cause,
cause
ataxia
(imbalance,
impaired
unsteady
gait),
tremor,
gaze‐evoked
nystagmus,
slow
gaze
pursuit
saccade
accuracy,
speech
deficits
(slurred,
scanning,
or
staccato).
We
explore
how
contribute
reviewing
data
on
genetic,
infectious,
neuroinflammatory
disorders.
Evidence
comes
animal
studies
human
neuropathology
structural
magnetic
resonance
imaging
(MRI),
functional
diffusion
tensor
MRI,
positron
emission
single
photon
computerized
tomography,
depth
electrode
electro‐encephalography
studies.
lesions
infrequently
focal
motor,
autonomic,
bilateral
tonic–clonic
seizures.
Antiseizure
medication–resistant
typically
presents
infancy
before
age
1
year
hemifacial
clonic
tonic
seizures
ipsilateral
the
mass.
Lesions
are
asymmetric
benign
low‐grade
tumors
floor
fourth
ventricle
involving
peduncles
extending
hemisphere.
Electrical
stimulation
cerebellum
has
yielded
conflicting
results
efficacy,
methodological
issues
confound
interpretation.
Epilepsy‐related
comorbidities
including
cognitive
falls,
sudden
unexpected
death
may
also
be
impacted
by
dysfunction.
discuss
drive
epilepsies,
seizure
therapies
dysfunction,
our
understanding
epilepsy‐related
through
basic
neuroscience,
animals
models
patient
advance
improve
outcomes.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
15(2), P. 722 - 736
Published: June 3, 2024
The
translocator
protein
(TSPO)
positron
emission
tomography
(PET)
can
noninvasively
detect
neuroinflammation
associated
with
epileptogenesis
and
epilepsy.
This
study
explored
the
role
of
TSPO-targeting
radioligand
[18F]F-TFQC,
an
m-trifluoromethyl
ER176
analog,
in
PET
neuroimaging
epileptic
rats.
Initially,
[18F]F-TFQC
was
synthesized
a
radiochemical
yield
8%–10%
(EOS),
purity
over
99%,
specific
activity
38.21
±
1.73
MBq/nmol
(EOS).
After
determining
that
exhibited
good
biochemical
properties,
performed
rats
at
multiple
time
points
various
stages
disease
progression.
imaging
showed
uptake
right
hippocampus
(KA-injected
site,
i.e.,
epileptogenic
zone),
which
most
pronounced
1
week
(T/NT
1.63
0.21)
month
1.66
0.20).
results
were
further
validated
using
autoradiography
pathological
analysis.
Thus,
reflect
TSPO
levels
localize
zone,
thereby
offering
potential
for
monitoring
guiding
anti-inflammatory
treatment
patients
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 14, 2024
Temporal
lobe
epilepsy
(TLE)
is
associated
with
abnormal
dynamic
functional
connectivity
patterns,
but
the
changes
in
brain
activity
at
each
time
point
remain
unclear,
as
does
potential
molecular
mechanisms
temporal
characteristics
of
TLE.
Resting-state
magnetic
resonance
imaging
(rs-fMRI)
was
acquired
for
84
TLE
patients
and
35
healthy
controls
(HCs).
The
data
then
used
to
conduct
HMM
analysis
on
rs-fMRI
from
an
HC
group
order
explore
intricate
dynamics
cognitive
impairment
(TLE-CI).
Additionally,
we
aim
examine
gene
expression
profiles
modular
using
Allen
Human
Brain
Atlas
(AHBA)
database.
Five
states
were
identified
this
study.
Compared
HCs,
TLE-CI
exhibited
distinct
dynamics,
including
fractional
occupancy,
lifetimes,
mean
dwell
switch
rate.
Furthermore,
transition
probability
across
significantly
different
between
(p
<
0.05).
reconfiguration
several
networks
(including
high-order
default
mode
network
(DMN),
subcortical
(SCN),
cerebellum
(CN).
a
total
1580
genes
revealed
be
TLE,
mainly
enriched
neuronal
signaling
synaptic
function.
This
study
provides
new
insights
into
characterizing
neural
defined
by
may
deepen
our
understanding
neurobiological
underpinnings
TLE-CI,
indicating
linkage
configuration
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9821 - 9821
Published: Sept. 11, 2024
Understanding
the
molecular
mechanisms
underlying
generation
of
absence
seizures
is
crucial
for
developing
effective,
patient-specific
treatments
childhood
epilepsy
(CAE).
Currently,
one-third
patients
remain
refractive
to
antiseizure
medications
(ASMs),
previously
called
antiepileptic
drugs
(AEDs),
available
treat
CAE.
Additionally,
these
ASMs
often
produce
serious
side
effects
and
can
even
exacerbate
symptoms
in
some
patients.
Determining
precise
cellular
directly
responsible
causing
this
type
has
proven
challenging
as
they
appear
be
complex
multifactorial
with
different
genetic
backgrounds.
Aberrant
neuronal
activity
CAE
may
caused
by
several
that
are
not
fully
understood.
Thus,
dissecting
causal
factors
could
targeted
development
precision
medicines
without
remains
a
high
priority
ultimate
goal
field
research.
The
aim
review
highlight
our
current
understanding
potential
causative
seizure
generation,
based
on
latest
research
using
cutting-edge
technologies.
This
information
will
important
identifying
targets
future
therapeutic
intervention.
Biomedical Signal Processing and Control,
Journal Year:
2023,
Volume and Issue:
90, P. 105811 - 105811
Published: Dec. 7, 2023
The
unclear
propagation
pathway
of
seizures
is
one
the
main
reasons
for
failure
surgical
treatment,
and
process
involves
directional
brain
networks.
However,
few
network
analysis
techniques
have
successfully
traced
specific
seizure
pathways.
This
study
proposed
a
stepwise
transfer
entropy
(STE)
approach
to
describe
effective
connections
in
STE
technique
applied
stereoelectroencephalography
(SEEG)
data
collected
from
patients
with
epilepsy,
which
can
identify
characteristic
regions
connected
seed
at
different
link-step
levels.
Importantly,
underlying
TE-based
construction
method
accurately
obtain
electrode-to-electrode
connections,
capture
interactions
between
electrodes
connection
level.
Finally,
simulation
clinical
were
used
evaluate
according
similarity,
confusion
matrix,
accuracy
recall.
We
three
datasets:
dataset,
public
dataset.
compared
results
methods
multiple
datasets,
captured
node
changes
epilepsy
patients,
effectively
identified
early
late
nodes,
determined
pathway.
Moreover,
superior
other
all
evaluation
indices,
achieving
97.9%
0.93
similarity.
Compared
existing
methods,
has
significant
advantages
tracking
simple
quickly
performs
calculations,
making
it
an
easy-to-use
promising
determining
pathways
settings.
