Nanoparticles based Cancer Therapeutics: Recent Practices DOI Open Access

Eiman Zahid

Asian Journal of Medicine and Biomedicine, Journal Year: 2023, Volume and Issue: 7(2), P. 173 - 198

Published: Oct. 20, 2023

Despite of the advancements in treating cancer, it is yet one dominant causes death worldwide. The current therapies are either incapable against certain cancers or impeding to patients, which diminishes their personal satisfaction. utilization nanoparticles cancer treatment might possibly increment patient endurance, decrease secondary effects and diminish rates. fundamental constraint therapeutics an absence explicitness conveyance as they target normal cells too. advancement nanoscale carriers can defeat both growth hindrances well give explicit, designated conveyance. This study also aims focus on therapeutic strategies different types have been discussed comprehensively. Moreover, nanomedicines addressed end highlight some more possible measures.

Language: Английский

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease DOI
Gabriele De Rubis, Keshav Raj Paudel, Leander Corrie

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(5), P. 2793 - 2833

Published: Nov. 22, 2023

Language: Английский

Citations

33
Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review DOI Creative Commons

Mohammad Saleh Sadeghi,

Mohadeseh lotfi,

Narges Soltani

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 20, 2023

Abstract Carcinoma of the lung is among most common types cancer globally. Concerning its histology, it categorized as a non-small cell carcinoma (NSCLC) and small (SCLC) subtype. MicroRNAs (miRNAs) are member non-coding RNA whose nucleotides range from 19 to 25. They known be critical regulators via epigenetic control oncogenes expression by regulating tumor suppressor genes. miRNAs have an essential function in tumorous microenvironment modulating growth, metastasis, angiogenesis, metabolism, apoptosis. Moreover, wide information produced several investigations indicates their tumor-suppressing, oncogenic, diagnostic assessment, predictive marker functions different malignancy. miRNA mimics or anti-miRNAs can transferred into cell, with possible curative implications. As result, hold promise targets for treatment detection. In this study, we investigate various malignancy, which been achieved recent years that show cancer-associated regulation expression, concerning beginning, development, resistance chemotherapy, also probability utilize biomarkers therapy reaction. Graphical abstract

Language: Английский

Citations

21
Epithelial–mesenchymal transition to Mitigate Age-Related Progression in Lung Cancer DOI
Riya Thapa,

Saurabh Gupta,

Gaurav Gupta

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102576 - 102576

Published: Nov. 7, 2024

Language: Английский

Citations

8
Oligonucleotide‐Based Modulation of Macrophage Polarization: Emerging Strategies in Immunotherapy DOI Creative Commons

Hanfu Zhang,

Yizhi Yu,

Cheng Qian

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

ABSTRACT Background Recent advances in immunotherapy have spotlighted macrophages as central mediators of disease treatment. Their polarization into pro‑inflammatory (M1) or anti‑inflammatory (M2) states critically influences outcomes cancer, autoimmunity, and chronic inflammation. Oligonucleotides emerged highly specific, scalable, cost‑effective agents for reprogramming macrophage phenotypes. Objective To review oligonucleotide strategies—including ASOs, siRNAs, miRNA mimics/inhibitors, aptamers—for directing their therapeutic implications. Review Scope We examine key signaling pathways governing M1/M2 phenotypes, describe four classes oligonucleotides mechanisms, highlight representative preclinical clinical applications. Key Insights Agents such AZD9150, MRX34, AS1411 demonstrate inflammation, infection models. Advances ligand‑conjugated nanoparticles chemical modifications improve delivery stability, yet immunogenicity, off‑target effects, formulation challenges remain significant barriers. Future Perspectives Optimizing platforms, enhancing molecular rigorous safety profiling are critical. Integration with emerging modalities—such engineered CAR‑macrophages—will enable precise, disease‑specific interventions, advance oligonucleotide‑guided modulation toward translation.

Language: Английский

Citations

0
Exosomes—Promising Carriers for Regulatory Therapy in Oncology DOI Open Access
Teresa Maria Jóźwicka, Patrycja Erdmańska, Agnieszka Stachowicz-Karpińska

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 923 - 923

Published: Feb. 25, 2024

Extracellular vesicles (EVs), including exosomes and microvesicles, together with apoptotic bodies form a diverse group of nanoparticles that play crucial role in intercellular communication, participate numerous physiological pathological processes. In the context cancer, they can allow transfer bioactive molecules genetic material between cancer cells surrounding stromal cells, thus promoting such processes as angiogenesis, metastasis, immune evasion. this article, we review recent advances understanding how EVs, especially exosomes, influence tumor progression modulation microenvironment. The key mechanisms include inducing epithelial-mesenchymal transition, polarizing macrophages toward protumoral phenotypes, suppressing antitumor immunity. therapeutic potential engineered is highlighted, their loading drugs, RNA therapeutics, or antigens to alter Current techniques for isolation, characterization, engineering are discussed. Ongoing challenges improving exosome efficiency, optimizing biodistribution, enhancing selective cell targeting. Overall, present promising opportunities understand tumorigenesis develop more targeted diagnostic strategies by exploiting natural communication networks tumors. oncology, regulatory therapy provides possibility reproducing original conditions unfavorable existence process may be feasible alternative population treatments. We also current access technology enabling intervention using exosomes.

Language: Английский

Citations

3
May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment? DOI Open Access
Iason Psilopatis, Ioannis Karniadakis, Konstantinos Stylianos Danos

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 93 - 93

Published: Dec. 21, 2022

Lung cancer (LC) is the leading cause of death in United States. Erythropoietin-producing hepatocellular receptors (EPHs) comprise largest receptor tyrosine kinases (RTKs) family mammals. EPHs along with their ligands, EPH-family receptor-interacting proteins (ephrins), have been found to be either up- or downregulated LC cells, hence exhibiting a defining role carcinogenesis and tumor progression. In capacity as membrane-bound molecules, EPHs/ephrins may represent feasible targets context precision treatment. order investigate available therapeutics targeting EPH/ephrin system LC, literature review was conducted, using MEDLINE, LIVIVO, Google Scholar databases. EPHA2 most well-studied target The EPHA2, EPHA3, EPHA5, EPHA7, EPHB4, EPHB6, ephrin-A1, ephrin-A2, ephrin-B2, ephrin-B3 cells xenograft models not only directly correlates profound suppression but also enriches effects well-established therapeutic regimens. However, sole clinical trial incorporating NSCLC patient could describe objective anti-cancer after anti-EPHA2 antibody administration. Collectively, seem promising treatment LC. large trials still need performed, view examining setting.

Language: Английский

Citations

12
Non-Coding RNAs in Airway Diseases: A Brief Overview of Recent Data DOI Open Access
Giusy Daniela Albano, Rosalia Gagliardo, Angela Marina Montalbano

et al.

Cancers, Journal Year: 2022, Volume and Issue: 15(1), P. 54 - 54

Published: Dec. 22, 2022

Inflammation of the human lung is mediated in response to different stimuli (e.g., physical, radioactive, infective, pro-allergenic, or toxic) such as cigarette smoke and environmental pollutants. These often promote an increase inflammatory activities airways, manifesting themselves chronic diseases allergic airway diseases, asthma bronchitis/chronic obstructive pulmonary disease, even cancer). Non-coding RNA (ncRNAs) are single-stranded molecules few nucleotides that regulate gene expression involved many cellular processes. ncRNA typically reduction translation stability genes mRNAs s. They biological aspects growth, proliferation, differentiation, regulation cell cycle, aging, apoptosis, metabolism, neuronal patterning, influence a wide range biologic processes essential for maintenance homeostasis. The relevance ncRNAs pathogenetic mechanisms respiratory has been widely established last decade papers were published. However, once their importance mechanisms, it becomes important further deepen research this direction. In review we describe several most recent knowledge concerning (overall miRNAs) lung.

Language: Английский

Citations

10
Oncogenic MicroRNAs: Key players in human prostate cancer pathogenesis, a narrative review DOI
Ali Moradi, Unes Sahebi, Hamid Nazarian

et al.

Urologic Oncology Seminars and Original Investigations, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Down-regulation of MicroRNA-137 Improves Proliferation of Oral Squamous Cell Carcinoma by Up-regulation of NF-Y DOI Creative Commons

Amira Abdel Azeem Saber,

Safaa Tohamy,

Maii Ibrahim Ali Sholqamy

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 34(2), P. 241 - 250

Published: June 1, 2024

Aim: The purpose of our study was to investigate the impact miR-137 suppression on growth OECM-1 human tongue SCC cell line. In addition, by targeting NF-Y gene, we also studied molecular mechanism miR-137. Methods: (OECM-1) & negative control (SCC-15) cells were transfected with microRNA137 inhibitor, MTT assay utilized ascertain cytotoxic impact. SYBER green-based quantitative polymerase chain reaction used determine expression level both and genes in treated untreated cells. collected data subjected One-way analysis variance (ANOVA) Tukey's multiple comparisons test.RESULTS: According research, an inhibitor significantly increased their ability proliferate when compared samples control. Also, reported that is down regulated OSCC associated 1.4 folds increase cells.CONCLUSION: MiR-137 lines normal its inhibition has a significant proliferation which reflects tumor suppressor role OSCC. marked suggested new target for

Language: Английский

Citations

0
Oligonucleotide-Based Modulation of Macrophage Polarization: Emerging Strategies in Immunotherapy DOI
Hanfu Zhang,

Cheng Qian

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Recent advancements in immunotherapy spotlight the pivotal role of macrophages disease treatment. The polarization macrophages, wherein these immune cells differentiate into either pro-inflammatory (M1) or anti-inflammatory (M2) states, plays a vital therapeutic modulation spectrum diseases. Oligonucleotides have emerged as potent tools for modulating macrophage with high specificity and potential cost-effectiveness compared to traditional therapies. In this review, we delve application oligonucleotides steering polarization, introducing how is polarized 4 different kinds oligonucleotide (ASO, siRNA, agomir/antagomir aptamer) works, discusses their potentials challenges associated strategies, emphasizing importance precise, disease-specific interventions by presenting actual examples. While clinical faces challenges, also highlights some recent, significant advances current trials future stimulating advantages immunotherapy, signaling frontier treatment management.

Language: Английский

Citations

0