Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3221 - 3221

Published: Feb. 6, 2023

Emerging evidence suggests that an important function of the sleeping brain is removal wastes and toxins from central nervous system (CNS) due to activation waste (BWRS). The meningeal lymphatic vessels (MLVs) are part BWRS. A decrease in MLV associated with Alzheimer’s Parkinson’s diseases, intracranial hemorrhages, tumors trauma. Since BWRS activated during sleep, a new idea now being actively discussed scientific community: night stimulation might be innovative promising strategy for neurorehabilitation medicine. This review highlights trends photobiomodulation BWRS/MLVs deep sleep as breakthrough technology effective unnecessary compounds order increase neuroprotection CNS well prevent or delay various diseases.

Language: Английский

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Detecting individuals with severe mental illness using artificial intelligence applied to magnetic resonance imaging

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104541 - 104541

Published: March 28, 2023

Language: Английский

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Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 19, 2024

Abstract Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose this systematic review was to determine whether PBM-combined provides additional benefits over monotherapies neurologic neuropsychiatric In addition, describes most commonly used methods PBM parameters these conjunctional approaches. To accomplish this, search conducted Google Scholar, PubMed, Scopus databases through January 2024. 95 potentially eligible articles on strategies for neurological neuropsychological disorders were identified, including 29 preclinical 66 trials. According findings, seven major categories identified based disease type: diseases, neurodegenerative ischemia, nerve injury, pain, paresis, neuropathy. These looked at effects laser combination therapies like pharmacotherapies, physical therapies, exercises, stem cells, experimental materials both animal models humans. findings suggested could produce synergistic effects, leading better outcomes treating psychiatric relieving symptoms. indicate be useful adjunct conventional treatments psychological

Language: Английский

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Photobiomodulation: Evolution and Adaptation

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2022, Volume and Issue: 40(4), P. 213 - 233

Published: March 30, 2022

Photobiomodulation (PBM) can be described as the intentional use of low-power laser or light-emitting diode light in visible and near-infrared spectra a medical treatment to living biological tissues. This article describes evolution photochemical reactions on Earth, mitochondria, their implications PBM; science energy (necessary understand mechanisms PBM); clinical therapeutic medicine. Finally, selected reviews current protocols ongoing research regarding possibilities for PBM human body are examined.

Language: Английский

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Photobiomodulation therapy in mood disorders: a systematic review

Lasers in Medical Science, Journal Year: 2022, Volume and Issue: 37(9), P. 3343 - 3351

Published: Nov. 21, 2022

Language: Английский

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Brain–gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 354, P. 574 - 588

Published: March 14, 2024

Chronic stress is an important risk factor for the development of major depressive disorder (MDD). Recent studies have shown microbiome dysbiosis as one pathogenic mechanisms associated with MDD. Thus, it to find novel non-pharmacological therapeutic strategies that can modulate gut microbiota and brain activity. One such strategy photobiomodulation (PBM), which involves non-invasive use light.

Language: Английский

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Dosimetry in cranial photobiomodulation therapy: effect of cranial thickness and bone density

Lasers in Medical Science, Journal Year: 2024, Volume and Issue: 39(1)

Published: Feb. 22, 2024

This research aims to examine the influence of human skull bone thickness and density on light penetration in PBM therapy across different wavelengths, focusing how these characteristics affect absorption therapeutic light. Analyses explored effect PBM, specifically using Low-Level Laser Therapy (LLLT) for efficacy prediction. Measurements were taken precise tools. approach emphasizes LLLT's significance enhancing outcomes by assessing penetration. The study revealed no significant correlation between capability photobiomodulation (PBM) therapy, challenging initial expectations. Wavelengths 405 nm 665 showed stronger correlations with density, suggesting a yet weak impact. Conversely, wavelengths 532 nm, 785 810 830 980 1064 low correlations, indicating minimal impact from variations. However, data variability (R2 < 0.4) suggests that neither nor robustly predicts power traversing bone, might be more influenced at certain wavelengths. finds effectiveness isn't just based but involves complex interplay factors. These include bone's chemical mineral composition, light's wavelength energy dose, treatment duration frequency, location where is applied skull.

Language: Английский

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Brain photobiomodulation therapy on neurological and psychological diseases

Journal of Biophotonics, Journal Year: 2023, Volume and Issue: 17(1)

Published: July 5, 2023

Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the mitochondrial respiratory chain can be stimulated by red light, which increases ATP synthesis. In addition, ion channels' light absorption causes release Ca

Language: Английский

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Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 913 - 930

Published: Jan. 1, 2023

Rationale: Adverse experiences in early life including abuse, trauma and neglect, have been linked to poor physical mental health outcomes. Emerging evidence implies that those who experienced adversity (ELA) are more likely develop cognitive dysfunction depressive-like symptoms adulthood. The molecular mechanisms responsible for the negative consequences of ELA, however, remain unclear. In absence effective management options, anticipatory guidance is mainstay ELA prevention. Furthermore, there no available treatment prevents or alleviates neurologic sequelae especially traumatic stress. Hence, present study aims investigate these associations evaluate whether photobiomodulation (PBM), a non-invasive therapeutic procedure, can prevent behavioral manifestations later life. Methods: was induced by repeated inescapable electric foot shock rats from postnatal day 21 26. On immediately following last shock, 2-min daily PBM applied transcranially 7 consecutive days. Cognitive depression-like behaviors were measured battery tests Subsequently, oligodendrocyte progenitor cells (OPCs) differentiation, proliferation apoptosis lineage (OLs), mature oligodendrocyte, myelinating level oxidative damage, reactive oxygen species (ROS) total antioxidant capacity analyzed using immunofluorescence staining, capillary-based immunoassay (ProteinSimple®) assay kit. Results: exposed exhibited obvious dysfunction, reduction OPCs diminished generation survival OLs, decreased matured oligodendrocyte. deficit oligodendrocytes observed, conjunction with an imbalance redox homeostasis accumulated damage. These alternations concomitant behaviors. Importantly, we found largely prevented pathologies reversed resulting ELA. Conclusions: Collectively, findings provide new insights into mechanism which affects neurological Moreover, our support may be promising strategy ELA-induced develops

Language: Английский

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Repeated Photobiomodulation Induced Reduction of Bilateral Cortical Hemodynamic Activation During a Working Memory Task in Healthy Older Adults

IEEE Journal of Biomedical and Health Informatics, Journal Year: 2023, Volume and Issue: 27(6), P. 2876 - 2885

Published: March 20, 2023

Transcranial photobiomodulation (tPBM) is an emerging non-invasive light-based neuromodulation technique that shows promising potential for improving working memory (WM) performance in older adults. However, the neurophysiological mechanisms associated with tPBM underlie improvement of WM and persistence such have not been investigated. Sixty-one healthy adults were recruited to receive a baseline sham stimulation, followed by one-week active (12 min daily, 1064-nm laser, 250 mW/cm ² ) three-week follow-ups. N-back task was conducted on post-stimulation baseline, first (Day 1) seventh 7) days treatment, at During task, functional near-infrared spectroscopy (fNIRS) imaging employed record cortical hemodynamic changes. Brain activations during follow-up sessions compared determine how had changed activity long these changes persisted. We found stimulation Day 1 induced significantly decreased activation right hemisphere 3-back. The expanded from only both hemispheres 7. persisted one week supramarginal gyrus left angular two weeks somatosensory association cortex. These accompanied improved accuracy N-back. findings provide important evidence understanding neural underlying cognitive enhancement after tPBM.

Language: Английский

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