Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 339, P. 933 - 942
Published: July 20, 2023
Language: Английский
Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 339, P. 933 - 942
Published: July 20, 2023
Language: Английский
Journal of Child Psychology and Psychiatry, Journal Year: 2023, Volume and Issue: 64(12), P. 1652 - 1664
Published: Aug. 17, 2023
Study objectives An evening circadian preference is common among adolescents. It characterized by a behavioral predilection for later sleep and wake timing associated with higher rates of Major Depressive Disorder (MDD). The present study aims to (a) test the effectiveness cognitive intervention (Transdiagnostic Sleep Circadian Intervention; TranS‐C) in sample adolescents an clinically significant depressive symptoms (b) evaluate improved alignment between biology sleep–wake behavior as potential mechanism relationship depression symptom improvement. Methods Adolescents were randomized receive TranS‐C ( n = 24) or psychoeducation condition (PE; 18). Alignment was measured using objective biological measurement. Measures rhythm taken at pre‐ posttreatment, posttreatment 6‐ 12‐month follow‐up. Results Mixed effects modeling revealed that compared active control condition, resulted reduction MDD severity A MacArthur mediation analysis conducted explore mediator through follow‐up interaction change treatment arm, indicating improvements outcomes under condition. Conclusions These results provide novel evidence specific improvement, key clues into complex depression, have clinical implications depression.
Language: Английский
Citations
8Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 6, 2023
Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural drug-based rewards. Chronic disruption of caused by unsteady synchronization with light-dark (LD) schedules, advancing chronic jet lag (CJL), leads adverse effects pathologies, is linked changes in mood depressive behaviors humans rodent models. Methods: C57BL/6J male mice were subjected through phase advances 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle used controls. After 8 weeks these conditions, a battery behavioral tests was performed assess if mood-related affected. Results: Compared controls 24 CJL presented desynchronization activity-rest rhythms that led several impairments, including decrease motivation for food reward, an increase anxiety, anhedonia, depressive-like behavior. Conclusion: disruption, experimental protocol, affects reward-related mice. Understanding importance its potential role due important maintaining good health well-being.
Language: Английский
Citations
8Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 5, 2023
Epidemiological studies have demonstrated an association between bipolar disorder (BP) and endocrine diseases. Further, circadian rhythm disruptions may be a potential common pathophysiological mechanism of both disorders. This review provides brief overview the molecular mechanisms rhythms, as well roles rhythms play in BP comorbidities such diabetes thyroid disease. Treatments targeting system, pharmacological non-pharmacological, are also discussed. The hope is to elicit new interest importance system offer entry points impetus development medicine.
Language: Английский
Citations
7Bipolar Disorders, Journal Year: 2023, Volume and Issue: 25(3), P. 191 - 199
Published: Jan. 20, 2023
Emerging evidence suggests a role of circadian dysrhythmia in the switch between "activation" states (i.e., objective motor activity and subjective energy) bipolar I disorder.
Language: Английский
Citations
7Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 339, P. 933 - 942
Published: July 20, 2023
Language: Английский
Citations
7