Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy DOI

David W. Sosnowski,

Darlynn M. Rojo‐Wissar, Gang Peng

et al.

Developmental Psychobiology, Journal Year: 2024, Volume and Issue: 66(2)

Published: Jan. 28, 2024

Abstract Maternal exposure to childhood adversity is associated with detrimental health outcomes throughout the life span and may have implications for offspring. Evidence links maternal adverse experiences (ACEs) birth outcomes, yet impact on infant's epigenome unclear. Moreover, sleep habits during pregnancy influence this association. Here, we explore whether restless moderates association between infant epigenetic age acceleration in 332 mother–infant dyads (56% female; 39% Black; 25% Hispanic). During second trimester, mothers self‐reported past‐week sleep; DNA methylation from umbilical vein endothelial cells was used estimate five clocks. Multivariable linear regression test study hypotheses. Despite no evidence of main effects, there an interaction ACEs predicting using EPIC gestational clock. Only infants whose reported both demonstrated accelerated aging. Results provide preliminary that epigenome.

Language: Английский

Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions DOI Creative Commons
George M. Slavich, Lydia G. Roos, Summer Mengelkoch

et al.

Health Psychology Review, Journal Year: 2023, Volume and Issue: 17(1), P. 5 - 59

Published: Jan. 2, 2023

Classic theories of stress and health are largely based on assumptions regarding how different psychosocial stressors influence biological processes that, in turn, affect human behavior. Although theoretically rich, this work has yielded little consensus led to numerous conceptual, measurement, reproducibility issues. Social Safety Theory aims address these issues by using the primary goal regulatory logic brain immune system as basis for specifying social-environmental situations which systems should respond most strongly maximize reproductive success survival. This analysis gave rise integrated, multi-level formulation described herein, transforms thinking about biology provides a biologically based, evolutionary account why experiences social safety threat related health, well-being, aging, longevity. In doing so, theory advances testable framework investigating biopsychosocial roots disparities well health-relevant crystalize over time perceptions environment interact with childhood microbial environment, birth cohort, culture, air pollution, genetics, sleep, diet, personality, self-harm health. The also highlights several interventions reducing promoting resilience.

Language: Английский

Citations

59
From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction DOI Open Access
Lisa Simon, Roee Admon

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(10), P. 1425 - 1435

Published: June 30, 2023

Language: Английский

Citations

27
Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review DOI Creative Commons
Gabrielle R. Rinne,

Jenna Hartstein,

Christine M. Guardino

et al.

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 153, P. 106115 - 106115

Published: April 18, 2023

Stress before conception and during pregnancy is associated with less favorable maternal child health. Alterations in prenatal cortisol levels may serve as a central biological pathway linking stress to adverse Research examining associations between from childhood through has not been comprehensively reviewed.

Language: Английский

Citations

26
The impact of race, ethnicity, and socioeconomic status on early adolescent sleep disturbances for youth exposed to adverse childhood experiences DOI
Thea Senger‐Carpenter, Terri Voepel‐Lewis, Sarah A. Stoddard

et al.

Child Abuse & Neglect, Journal Year: 2025, Volume and Issue: 160, P. 107236 - 107236

Published: Jan. 5, 2025

Language: Английский

Citations

1
Associations between childhood maltreatment and behavioral sleep disturbances across the lifespan: A systematic review DOI Creative Commons
Samantha M. Brown, Kerri E. Rodriguez,

Amy D. Smith

et al.

Sleep Medicine Reviews, Journal Year: 2022, Volume and Issue: 64, P. 101621 - 101621

Published: March 5, 2022

Language: Английский

Citations

37
Sleep and disparities in child and adolescent development DOI
Mona El‐Sheikh, Brian T. Gillis, Ekjyot K. Saini

et al.

Child Development Perspectives, Journal Year: 2022, Volume and Issue: 16(4), P. 200 - 207

Published: Sept. 8, 2022

Sleep is a robust predictor of child and adolescent development. Race/ethnicity, socioeconomic status (SES), related experiences (e.g., discrimination) are associated with sleep, but researchers have just begun to understand the role sleep in development racial/ethnic SES disparities broader psychosocial adjustment cognitive functioning during childhood adolescence. In this article, we discuss poor as potential mechanism contributing such disparities, better protective factor that diminishes disparities. We conclude by offering recommendations for research advance understanding key bioregulatory system may underlie or protect against detrimental developmental outcomes adversity belonging historically minoritized group.

Language: Английский

Citations

29
The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology DOI Creative Commons
Rachel Gilgoff, Summer Mengelkoch, Jorina Elbers

et al.

Stress, Journal Year: 2024, Volume and Issue: 27(1)

Published: May 6, 2024

Although dysregulated stress biology is becoming increasingly recognized as a key driver of lifelong disparities in chronic disease, we presently have no validated biomarkers toxic physiology; biological, behavioral, or cognitive treatments specifically focused on normalizing processes; and agreed-upon guidelines for treating the clinic evaluating efficacy interventions that seek to reduce improve human functioning. We address these critical issues by (a) systematically describing systems mechanisms are stress; (b) summarizing indicators, biomarkers, instruments assessing response systems; (c) highlighting therapeutic approaches can be used normalize stress-related biopsychosocial also present novel multidisciplinary Stress Phenotyping Framework bring researchers clinicians one step closer realizing goal using precision medicine-based prevent treat stress-associated health problems.

Language: Английский

Citations

7
The effects of childhood trauma on stress-related vulnerability factors and indicators of suicide risk: An ecological momentary assessment study DOI Creative Commons

Olivia Rogerson,

Rory C. O’Connor, Daryl B. O’Connor

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 352, P. 479 - 489

Published: Feb. 9, 2024

Childhood trauma is experienced by approximately one third of young people in the United Kingdom and has been shown to confer an increased risk for mental health difficulties adulthood. Understanding associations between these factors before negative outcomes manifest adulthood imperative help inform development interventions. The aims this study were two-fold; first, investigate effects childhood on daily stress-related vulnerability over a period 7 days test whether any observed relationships moderated protective or factors. Second, explore indirect reasons living, optimism, suicide ideation, defeat entrapment through 212 participants recruited ecological momentary assessment complete three diaries per day 7-day period. Participants completed measures stress, hassles, executive functioning, impulsivity, sleep quality (stress-related factors) as well thoughts suicide, entrapment. Trauma Questionnaire was also at baseline. Analyses found that significantly associated with higher scores positively related each indicators risk. uncovered key pathways whereby had stress. function self-reported future research ought replicate current findings using more objective methods. from highlight complexity its damaging impacts poorer outcomes. Greater understanding which may impact later essential

Language: Английский

Citations

6
Bidirectional associations between nightly sleep and daily happiness and negative mood in adolescents DOI
Chrystyna D. Kouros, Peggy S. Keller, Olivia Martín‐Piñón

et al.

Child Development, Journal Year: 2022, Volume and Issue: 93(5)

Published: May 21, 2022

This study examined bidirectional associations between daily happiness and negative mood subjective objective sleep measures. Participants were 311 adolescents (Mage = 17.37 years; 51.8% female; 59.2% White/European American, 38.6% Black/African 1% Hispanic/Latinx 1.4% multi-racial; 19.3% below poverty line) observed over a 7-day period (2017-2018) using diaries actigraphy. Daily was related to greater sleep/wake problems, lower problems. Conversely, shorter self-reported duration higher the next day. For actigraphy measures, efficiency, whereas efficiency. Differences in based on versus measures are discussed.

Language: Английский

Citations

20
Neighborhood environment and adolescent sleep: The role of family socioeconomic status DOI Creative Commons
Megan M. Zeringue, Ekjyot K. Saini, Thomas E. Fuller‐Rowell

et al.

Sleep Medicine, Journal Year: 2023, Volume and Issue: 109, P. 40 - 49

Published: June 21, 2023

Socioeconomic status (SES) and neighborhood context are influential predictors of adolescent sleep, yet little is known about how they may interact to influence sleep. We examined multiple dimensions family SES as moderators associations between risk sleep parameters. Participants were 323 adolescents (Mage = 17.4 years, SD 0.86; 48% male; 60% White/European American, 40% Black/African American). Sleep was assessed using 7 nights actigraphy from which duration (minutes onset wake time), efficiency, long episodes, variability in minutes over the week derived. Youth reported on their sleep/wake problems sleepiness, well perceptions safety violence neighborhoods. Parents indices, including income-to-needs ratio perceived financial stability. Lower (income-to-needs, stability) associated with lower efficiency more frequent episodes. greater community concerns related subjective problems. Moderation effects illustrated two general patterns. For actigraphy-derived variables, poor only among youth lower-income families. daytime difficulties pronounced for higher youth, while had regardless factors. Findings suggest that several be consequential adolescents' highlight significance considering contextual influences towards a better understanding

Language: Английский

Citations

11