Distinct limbic connectivity in left and right benign mesial temporal lobe epilepsy: Evidence from a resting state functional MRI study DOI Creative Commons
Chiara Pizzanelli, Ilaria Pesaresi, Chiara Milano

et al.

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 29, 2022

Background Functional connectivity (FC) studies showed that pharmaco-resistant mesial temporal lobe epilepsy (MTLE) affects not only the limbic system, but also several extra-limbic regions, including areas belonging to resting state networks. Less is known about FC in subjects with benign MTLE (i.e., sensitive antiseizure medication, bMTLE). Aim and methods We evaluated of hippocampus amygdala bMTLE, distinguished based on epileptic focus lateralization. enrolled 19 patients (10 left 9 right bMTLE) 10 age-matched healthy subjects. Connectivity was investigated at rest by using a seed-based regression analyses approach four regions interest (left hippocampus, amygdala). Patients were tested neuropsychological battery their scores correlated fMRI data. Results conclusions Our study documented an asymmetrical disruption relation side focus. Right exhibited limited altered connections, while subjects—who performed worse verbal memory tests—showed wide bilateral hypoconnectivity language network. The strength between network better performances tests. Moreover, we observed increased default mode network, more pronounced subjects, possible attempt compensate cognitive deficit without effectiveness. believe these findings could help characterize which dysfunction detectable despite well-controlled epilepsy.

Language: Английский

Automated Classification of Cognitive Decline and Probable Alzheimer's Dementia Across Multiple Speech and Language Domains DOI
Rui He, Kayla Chapin, Jalal Al‐Tamimi

et al.

American Journal of Speech-Language Pathology, Journal Year: 2023, Volume and Issue: 32(5), P. 2075 - 2086

Published: July 24, 2023

Decline in language has emerged as a new potential biomarker for the early detection of Alzheimer's disease (AD). It remains unclear how sensitive measures are across different tasks, domains, and languages, to what extent changes can be reliably detected stages such subjective cognitive decline (SCD) mild impairment (MCI).Using scene construction task speech elicitation Spanish/Catalan speaking cohort (N = 119), we automatically extracted features seven three acoustic (spectral, cepstral, voice quality), one prosodic, from text (morpholexical, semantic, syntactic). They were forwarded random forest classifier evaluate discriminability participants with probable AD dementia, amnestic nonamnestic MCI, SCD, cognitively healthy controls. Repeated-measures analyses variance paired-samples Wilcoxon signed-ranks test used assess whether performance differs significantly groups linguistic domains.The scores machine learning generally satisfactorily high, highest over .9. Model was domains (p < .001), versus .043), outperforming textual features, quality performing best. High diagnostic classification accuracies seen even within both (controls vs. SCD) MCI (amnestic nonamnestic) groups.Speech-based is powerful detecting dementia range feature though important differences exist between these well.https://doi.org/10.23641/asha.23699733.

Language: Английский

Citations

14
Disconnection from prediction: A systematic review on the role of right temporoparietal junction in aberrant predictive processing DOI
Fabio Masina, Rachele Pezzetta, Sara Lago

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 138, P. 104713 - 104713

Published: May 28, 2022

Language: Английский

Citations

21
Language learning in aphasia: A narrative review and critical analysis of the literature with implications for language therapy DOI Creative Commons
Claudia Peñaloza, Nadine Martin, Matti Laine

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 141, P. 104825 - 104825

Published: Aug. 11, 2022

People with aphasia (PWA) present language deficits including word retrieval difficulties after brain damage. Language learning is an essential life-long human capacity that may support treatment-induced recovery insult. This prospect has motivated a growing interest in the study of PWA during last few decades. Here, we critically review current literature on ability aphasia. The existing studies this area indicate (i) can remain functional some PWA, (ii) inter-individual variability performance large (iii) processing, short-term memory and lesion site are associated ability, (iv) preliminary evidence suggests relationship between treatment outcomes population. Based reviewed evidence, propose potential account for interplay memory/learning systems to explain spared/impaired its therapy PWA. Finally, avenues future research promote more cross-talk cognitive neuroscience rehabilitation.

Language: Английский

Citations

19
Gait control by the frontal lobe DOI
Kaoru Takakusaki

Handbook of clinical neurology, Journal Year: 2023, Volume and Issue: unknown, P. 103 - 126

Published: Jan. 1, 2023

Language: Английский

Citations

12
Modeling the neurocognitive dynamics of language across the lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 29, 2024

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting‐state fMRI neuropsychological data from 628 healthy adults (age 18–88) the CamCAN cohort, we performed state‐of‐the‐art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter‐cognitive synergy semantic domain‐general processes. cerebral show default mode network (DMN) suppression coupled fronto‐parietal (FPN) integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age‐related in LP. Relatedly, reduced DMN midlife could compromise ability manage cost FPN integration. This may prompt older adopt more cost‐efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel synergistic, economical, nonlinear, emergent, model, integrating connectomic dimensions within complex system perspective.

Language: Английский

Citations

4
Neural (re)organisation of language and memory: implications for neuroplasticity and cognition DOI
Alena Stasenko, Erik Kaestner, Jonathan Rodríguez

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. jnnp - 333871

Published: Jan. 31, 2025

In the presence of neurological insult, how language and memory networks jointly reorganise provides insights into mechanisms neuroplasticity can inform presurgical planning. As (re)organisation is often studied within a single cognitive modality, interact during in response to epilepsy implications for outcomes less clear. We investigated (1) rates patterns joint (2) their associations with pre- postsurgical function. Individuals (n=162) from three neurosurgical centres underwent Wada procedure. examined colateralisation (ie, concordance/discordance) between both global verbal (n=34), clinical characteristics preoperative postoperative outcomes. Overall concordance was minimal-to-weak across (kappa=0.28-0.44). Discordance primarily observed individuals left-lateralised language, whom 52% 32% showed discordance memory, respectively. most pronounced left hemisphere mesial temporal sclerosis. Conversely, right-lateralised consistently predicted (95%-100%), regardless seizure laterality or type. While not associated function, superior following surgery language-dominant (p<0.05; ηp 2=0.30). When dominance atypical, tends colateralise. However, when remains typical, weak, particularly onset. An interhemispheric shift may trigger possibly maintain efficient communication medial neocortical networks. contrast, appears able isolation, predicting better without detriment Our findings support continued need separate mapping lateralisation, case typical seizures.

Language: Английский

Citations

0
Brain-derived neurotrophic factor (BDNF) as a biomarker in stroke-induced aphasia recovery: a scoping review DOI

A.R. Mayes,

Elizabeth O. Tibus,

Anna Ree

et al.

Aphasiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 9, 2025

Language: Английский

Citations

0
Intranetwork and Internetwork Functional Connectivity Changes Related to Speech Disorders in Adults With Cleft Lip and Palate DOI
Yingying Wang,

Chengdan Deng,

Hailong Li

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(7)

Published: April 1, 2025

Cleft lip and palate (CLP) may induce alterations in functional connectivity (FC) throughout the whole brain, potentially leading to speech dysfunctions; however, precise neurobiological mechanisms involved remain unknown. This study aimed systematically examine consequences of neurological impairments associated with CLP on whole-brain FC functionality. A total 33 individuals 41 control participants were included this study. Eight meaningful brain networks identified through independent component analysis (ICA). The intergroup differences correlations scores for both intranetwork internetwork calculated. We observed decreased within sensorimotor network (SMN), default mode (DMN), cerebellar (CN) increased executive (ECN). Additionally, was enhanced between SMN auditory (AN), attention (ATN), salience (SAN); DMN visual (VN) ECN; two components DMN. Furthermore, significant altered assessment scores. Our research demonstrated that plasticity deficits involves widespread changes connectivity, significantly improving our understanding neural basis impairment individuals.

Language: Английский

Citations

0
Unraveling the functional attributes of the language connectome: crucial subnetworks, flexibility and variability DOI Creative Commons
Élise Roger, Lílian Rodrigues de Almeida, Hélène Lœvenbruck

et al.

NeuroImage, Journal Year: 2022, Volume and Issue: 263, P. 119672 - 119672

Published: Oct. 6, 2022

Language processing is a highly integrative function, intertwining linguistic operations (processing the language code intentionally used for communication) and extra-linguistic processes (e.g., attention monitoring, predictive inference, long-term memory). This synergetic cognitive architecture requires distributed specialized neural substrate. Brain systems have mainly been examined at rest. However, task-related functional connectivity provides additional valuable information about how processed when various states are involved. We gathered thirteen fMRI tasks in unique database of one hundred fifty neurotypical adults (InLang [Interactive networks Language] database), providing opportunity to assess features across wide range processes. Using this database, we applied network theory as computational tool model connectome (LANG atlas). The organization data-driven neurocognitive atlas was multiple levels, uncovering its major components (or crucial subnetworks), anatomical correlates. In addition, estimated reconfiguration function demand (flexibility) or several factors such age gender (variability). observed that discrete could be specifically shaped promote key language: coding-decoding (Net1), control-executive (Net2), abstract-knowledge (Net3), sensorimotor (Net4) functions. these pivotal brain regions varied according nature process, gender, age. By accounting multifaceted modulating factors, study can contribute enriching refining existing models language. LANG also considered reference comparative clinical studies involving patients conditions.

Language: Английский

Citations

17
Finding the Words: How Does the Aging Brain Process Language? A Focused Review of Brain Connectivity and Compensatory Pathways DOI Creative Commons
Monica Baciu, Élise Roger

Topics in Cognitive Science, Journal Year: 2024, Volume and Issue: unknown

Published: May 12, 2024

Abstract As people age, there is a natural decline in cognitive functioning and brain structure. However, the relationship between function cognition older adults neither straightforward nor uniform. Instead, it complex, influenced by multiple factors, can vary considerably from one person to another. Reserve, compensation, maintenance mechanisms may help explain why some maintain high levels of performance while others struggle. These are often studied concerning memory executive functions that particularly sensitive effects aging. language abilities also be affected with changes production fluency. The impact on needs further investigated understand dynamics patterns aging, especially successful We previously modeled several compensatory profiles lexical access/retrieval aging within Lexical Access Retrieval Aging (LARA) model. In present paper, we propose an extended version LARA model, called LARA‐Connectivity (LARA‐C), incorporating recent evidence connectivity. Finally, discuss factors influence strategies implemented LARA‐C model serve as framework individual open avenues for possible personalized interventions.

Language: Английский

Citations

3