Endophytic fungi and age-related diseases: Potential for geriatric therapeutics

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 295 - 313

Published: Jan. 1, 2025

Language: Английский

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A social conditioned place preference test and pair maintenance in the monogamous zebra finch

Physiology & Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 114925 - 114925

Published: April 1, 2025

Language: Английский

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Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner

Annals of the New York Academy of Sciences, Journal Year: 2024, Volume and Issue: 1535(1), P. 20 - 30

Published: April 9, 2024

Loss of a loved one is painful event that substantially elevates the risk for physical and mental illness impaired daily function. Socially monogamous prairie voles are laboratory-amenable rodents form life-long pair bonds exhibit distress upon partner separation, mirroring phenotypes seen in humans. These attributes make an excellent model studying biology loss. In this review, we highlight parallels between humans voles, focusing on reward system engagement during bonding As yearning unique feature differentiates loss from other negative states, posit which homeostatic mechanisms help to maintain disrupted loss, resulting impacts. Finally, synthesize studies delineate remodeling systems adaptation. The stalling these processes likely contributes prolonged grief disorder, diagnosis recently added Diagnostic Statistical Manual Psychiatry.

Language: Английский

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Epigenetic aging studies of pair bonding in prairie voles

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 29, 2024

The quality of romantic relationships can predict health consequences related to aging. DNA methylation-based biomarkers aging accurately estimate chronological age. We developed several highly accurate epigenetic clocks, based on conserved mammalian CpGs, for the socially monogamous prairie vole (Microtus ochrogaster). In addition, our dual-species human-vole clock measured relative age and illustrates high species conservation effects. Next, we assessed how pair bonding impacts did not find evidence that pair-bonded voles exhibit accelerated or decelerated effects in blood, ear, liver, brain tissue. Our epigenome wide association study identified CpGs five genes strongly associated with bonding: Foxp4, Phf2, Mms22l, Foxb1, Eif1ad. Overall, present estimators a great interest researchers studying monogamy animals. any sex-naive animals differently from

Language: Английский

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Oxytocin: A developmental journey

Comprehensive Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 16, P. 100203 - 100203

Published: Aug. 18, 2023

The neuropeptide hormone oxytocin is involved in many processes our bodies, linking social lives to internal states. I started out my career studying primate families, an interest that expanded into the role of family-oriented behaviors such as pair bonding and parenting prairie voles, humans, other primates. Starting a post-doc with Dr. C. Sue Carter, also became interested during development way we manipulate clinically. During then faculty member at University California, Davis, have worked on number these questions.

Language: Английский

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The fortunes and misfortunes of social life across the life course: A new era of research from field, laboratory and comparative studies

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105655 - 105655

Published: April 5, 2024

Language: Английский

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