Current understanding of iron homeostasis

American Journal of Clinical Nutrition, Journal Year: 2017, Volume and Issue: 106, P. 1559S - 1566S

Published: Oct. 25, 2017

Language: Английский

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Mitochondria as a Target of Environmental Toxicants

Toxicological Sciences, Journal Year: 2013, Volume and Issue: 134(1), P. 1 - 17

Published: April 29, 2013

Enormous strides have recently been made in our understanding of the biology and pathobiology mitochondria. Many diseases identified as caused by mitochondrial dysfunction, many pharmaceuticals previously unrecognized toxicants. A much smaller but growing literature indicates that mitochondria are also targeted environmental pollutants. We briefly review importance function maintenance for health based on genetics toxicities resulting from pharmaceutical exposure. then discuss how principles vulnerability illustrated those fields might apply to contaminants, with particular attention factors may modulate including genetic differences, epigenetic interactions, tissue characteristics, developmental stage. Finally, we related toxicants, a focus toxicants target DNA. conclude toxicology should more strongly

Language: Английский

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Environmental Toxins and Parkinson's Disease

The Annual Review of Pharmacology and Toxicology, Journal Year: 2013, Volume and Issue: 54(1), P. 141 - 164

Published: Sept. 20, 2013

Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder that begins in mid to late life and characterized by motor impairment, autonomic dysfunction, and, many, psychological cognitive changes. Recent advances have helped delineate pathogenetic mechanisms, yet the cause of PD most individuals unknown. Although at least 15 genes genetic loci been associated with PD, identified causes are responsible for only few percent cases. Epidemiologic studies found increased risk exposure environmental toxicants such as pesticides, solvents, metals, other pollutants, many these compounds recapitulate pathology animal models. This review summarizes toxicology highlighting consistency observations across cellular, animal, human pathogenesis.

Language: Английский

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Human health and environmental impacts of coal combustion and post-combustion wastes

Journal of Sustainable Mining, Journal Year: 2017, Volume and Issue: 17(2), P. 87 - 96

Published: Dec. 29, 2017

Due to its high energy generation potential, coal is widely used in power different countries. Although, the presence of carbon, hydrogen and sulfur facilitates combustion, some pollutants including COx, SOx, NOx, particulate matter (PM) heavy metals are accumulated air water lead severe environmental health impacts as a result leaching, volatilization, melting, decomposition, oxidation, hydration other chemical reactions. In addition, fly ash, both wet dry forms, mobilized induces bone deformities kidney dysfunction, particularly with exposure radionuclides. This review will cover impact these major (including PM, (traces)) on human environment. Given lack adequate data about cumulative based from this can be significant tool further explore disease-association risks design standard management protocols overcome associated assaults.

Language: Английский

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Neuroprotective Effect of Antioxidants in the Brain

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(19), P. 7152 - 7152

Published: Sept. 28, 2020

The brain is vulnerable to excessive oxidative insults because of its abundant lipid content, high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) increase susceptibility neuronal damage functional deficits, via changes in the neurodegenerative diseases. Overabundance abnormal levels ROS and/or overload metals are regulated by cellular defense mechanisms, intracellular signaling, physiological functions antioxidants brain. Single complex compounds targeting stress, redox metals, cell death have been evaluated multiple preclinical clinical trials as a complementary therapeutic strategy for combating stress associated with Herein, we present general analysis overview various suggest potential courses treatments neuroprotection from injury. This review focuses on enzymatic non-enzymatic mechanisms examines relative advantages methodological concerns when assessing treatment disorders.

Language: Английский

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Protective effect of curcumin against heavy metals-induced liver damage

Food and Chemical Toxicology, Journal Year: 2014, Volume and Issue: 69, P. 182 - 201

Published: April 18, 2014

Language: Английский

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“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

BMC Pharmacology and Toxicology, Journal Year: 2016, Volume and Issue: 17(1)

Published: Nov. 4, 2016

Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent advances in identifying mechanisms of Mn uptake and molecular actions the brain well promising neuroprotective strategies. The authors focused on reporting findings regarding transport mechanisms, effects cholinergic system, behavioral alterations induced exposure studies strategies against intoxication. We report that to may arise from environmental sources, occupational settings, food, total parenteral nutrition (TPN), methcathinone drug abuse or even genetic factors, such mutation transporter SLC30A10. Accumulation occurs mainly basal ganglia leads syndrome called manganism, whose symptoms cognitive dysfunction motor impairment resemble Parkinson's disease (PD). Various neurotransmitter systems be impaired due Mn, especially dopaminergic, but also GABAergic. Several proteins have been identified including divalent metal tranporter-1 (DMT-1), SLC30A10, transferrin ferroportin allow accumulation central nervous system. Parallel identification neurotoxic properties, reported, these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols non-characterized components), iron chelating agents, precursors glutathione (GSH), synthetic compounds can experimentally afford protection Mn-induced neurotoxicity.

Language: Английский

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Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

International Journal of Environmental Research and Public Health, Journal Year: 2015, Volume and Issue: 12(7), P. 7519 - 7540

Published: July 6, 2015

Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of brain may cause a parkinsonian-like syndrome, referred as manganism. The present review discusses advances made understanding essentiality neurotoxicity Mn. We occupational Mn-induced parkinsonism dynamic modes transport biological systems, well detection pharmacokinetic modeling trafficking. In addition, we some shared similarities, pathologic clinical distinctions between Parkinson's disease. Where possible, influence toxicity on dopamine, gamma aminobutyric acid (GABA), glutamate neurotransmitter levels conclude with survey preventive treatment strategies manganism idiopathic disease (PD).

Language: Английский

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Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: June 26, 2019

Occupational or environmental exposure to manganese (Mn) can lead the development of "Manganism", a neurological condition showing certain motor symptoms similar Parkinson's disease (PD). Like PD, Mn toxicity is seen in central nervous system mainly affecting nigrostriatal neuronal circuitry and subsequent behavioral impairments. Since first report Mn-induced 1837, various experimental epidemiological studies have been conducted understand this disorder. While early investigations focused on impact high concentrations mitochondria oxidative stress, current attempted elucidate cellular molecular pathways involved toxicity. In fact, recent reports suggest involvement misfolding proteins such as α-synuclein amyloid, thus providing credence theory that toxicants either initiate propagate neurodegenerative processes by interfering with disease-specific proteins. Besides manganism has also implicated other diseases Huntington's Prion diseases. many reviews homeostasis, aim review concisely synthesize what we know about its effect primarily respect role protein misfolding, mitochondrial dysfunction, consequently, neuroinflammation neurodegeneration. Based evidence, propose 'Mn Mechanistic Neurotoxic Triad' comprising 1) dysfunction 2) trafficking 3) neuroinflammation.

Language: Английский

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Metals and neurodegenerative diseases. A systematic review

Environmental Research, Journal Year: 2017, Volume and Issue: 159, P. 82 - 94

Published: Aug. 1, 2017

Language: Английский

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