Relationship between the cGAS−STING and NF-κB pathways-role in neurotoxicity DOI Open Access

Shiyin Zhong,

Qiongli Zhou,

Jirui Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116698 - 116698

Published: May 6, 2024

Neurotoxicity can cause a range of symptoms and disorders in humans, including neurodegenerative diseases, neurodevelopmental disorders, nerve conduction abnormalities, neuroinflammation, autoimmune cognitive deficits. The cyclic guanosine-adenosine synthase (cGAS)-stimulator interferon genes (STING) pathway NF-κB are two important signaling pathways involved the innate immune response. cGAS-STING is activated by recognition intracellular DNA, which triggers production type I interferons pro-inflammatory cytokines, such as tumor necrosis factor, IL-1β, IL-6. These cytokines play role oxidative stress mitochondrial dysfunction neurons. various stimuli, bacterial lipopolysaccharide, viral particle components, neurotoxins. activation may lead to promote neuroinflammation neuronal damage. A potential interaction exists between pathways, blocks STING degradation inhibiting microtubule-mediated transport. This review examines progress research on roles these neurotoxicity their interrelationships. Understanding mechanisms will provide valuable therapeutic insights for preventing controlling neurotoxicity.

Language: Английский

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation DOI Creative Commons
Anushruti Ashok,

Syed Suhail Andrabi,

Saffar Mansoor

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 408 - 408

Published: Feb. 17, 2022

Free radicals are formed as a part of normal metabolic activities but neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining redox balance. This balance is disrupted certain neuropathophysiological conditions, causing oxidative stress, which implicated several progressive neurodegenerative diseases. Following neuronal injury, secondary injury progression also caused excessive production free radicals. Highly reactive radicals, mainly oxygen species (ROS) and nitrogen (RNS), damage cell membrane, proteins, DNA, triggers self-propagating inflammatory cascade degenerative events. Dysfunctional mitochondria under stress conditions considered key mediator neurodegeneration. Exogenous delivery holds promise to alleviate regain In this regard, natural synthetic have been evaluated. Despite promising results preclinical studies, clinical translation therapy treat diseases remains elusive. The issues could be their low bioavailability, instability, limited transport target tissue, and/or poor antioxidant capacity, requiring repeated high dosing, cannot administered humans because dose-limiting toxicity. Our laboratory investigating nanoparticle-mediated enzymes address some above issues. Apart from being endogenous, main advantage catalytic mechanism action; hence, they significantly more effective at lower doses detoxifying deleterious effects than nonenzymatic antioxidants. review provides comprehensive analysis potential therapy, challenges translation, role nanoparticles/drug systems play addressing these challenges.

Language: Английский

Citations

129
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies DOI
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma

et al.

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

Citations

79
Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants DOI Creative Commons
Feng Jin,

Youle Zheng,

Mingyue Guo

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(10), P. 3988 - 4024

Published: July 16, 2023

In recent years, growing awareness of the role oxidative stress in brain health has prompted antioxidants, especially dietary to receive attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied antioxidants include active substances such vitamins, carotenoids, flavonoids and polyphenols. Dietary are found usually consumed foods fresh fruits, vegetables, nuts oils gaining popularity due recently their potential preventive protective agents against NDs, well abundant natural sources, generally non-toxic nature, ease long-term consumption. This review article examines development explores ‘two-sidedness’ blood–brain barrier (BBB) a nervous system an impeding use drug medicinal products and/or supplements prevention therapy reviews BBB permeability common suplements efficacy treatment NDs. Finally, current challenges future directions NDs using discussed, useful information on is provided.

Language: Английский

Citations

67
Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer’s Disease DOI Creative Commons
Germán Plascencia‐Villa, George Perry

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1628 - 1628

Published: Aug. 17, 2023

Alzheimer’s disease (AD) is a brain disorder that progressively undermines memory and thinking skills by affecting the hippocampus entorhinal cortex. The main histopathological hallmarks of AD are presence abnormal protein aggregates (Aβ tau), synaptic dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA RNA defects, inflammation, neuronal cell death. However, oxidative stress or damage also evident commonly overlooked considered consequence advancement dementia symptoms. control onset linked to activity amyloid-β peptide, which may serve as both antioxidant pro-oxidant molecules. Furthermore, correlated with proteins, nucleic acids, lipids in vulnerable populations, ultimately lead death through different molecular mechanisms. By recognizing an integral feature AD, alternative therapeutic preventive interventions developed tested potential complementary therapies for this devastating neurodegenerative disease.

Language: Английский

Citations

58
Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management DOI Creative Commons
Shehwaz Anwar, Faris Alrumaihi, Tarique Sarwar

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 697 - 697

Published: June 14, 2024

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as paramount enzymatic antioxidant. It efficiently catalyzes decomposition hydrogen peroxide (H

Language: Английский

Citations

44
ROS: Executioner of regulating cell death in spinal cord injury DOI Creative Commons
Zhaoyang Yin, Bowen Wan,

Ge Gong

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

The damage to the central nervous system and dysfunction of body caused by spinal cord injury (SCI) are extremely severe. pathological process SCI is accompanied inflammation nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in production reactive oxygen species (ROS) imbalance its clearance, plays a significant role secondary during SCI. transcription factor nuclear erythroid 2-related 2 (Nrf2) crucial regulatory molecule for cellular redox. This review summarizes recent advancements regulation ROS-Nrf2 signaling focuses on interaction between ROS different modes neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, ferroptosis. Furthermore, we highlight pathways through which materials science, including exosomes, hydrogels, nanomaterials, can alleviate modulating clearance. provides valuable insights directions reducing alleviating stress.

Language: Английский

Citations

30
Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection DOI Creative Commons
И. Ф. Беленичев, Olena Popazova,

Nina Bukhtiyarova

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 504 - 504

Published: April 23, 2024

Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.

Language: Английский

Citations

21
Free radicals and their impact on health and antioxidant defenses: a review DOI Creative Commons

Nisansala Chandimali,

Seon Gyeong Bak,

Eun Hyun Park

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated

Language: Английский

Citations

12
Oxidative Stress in Brain Function DOI Creative Commons

Daniela-Marilena Trofin,

Dragos-Petrica Sardaru,

Dan Trofin

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 297 - 297

Published: Feb. 28, 2025

Oxidative stress (OS) is an important factor in the pathophysiology of numerous neurodegenerative disorders, such as Parkinson's disease, multiple sclerosis, cerebrovascular pathology or Alzheimer's disease. OS also significantly influences progression among various disorders. The imbalance between formation reactive oxygen species (ROS) and body's capacity to neutralize these toxic byproducts renders brain susceptible oxidative injury. Increased amounts ROS can result cellular malfunction, apoptosis neurodegeneration. They represent a substantial mitochondrial dysfunction, defining characteristic Comprehending fundamental mechanisms its interactions with function, neuroinflammation protective pathways becomes essential for formulating targeted therapeutics maintain health reduce impacts We address recent highlights on role function terms significance neuronal

Language: Английский

Citations

2
Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications DOI
Praveen Kumar Issac, Ajay Guru, Manikandan Velayutham

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 283, P. 119864 - 119864

Published: Aug. 3, 2021

Language: Английский

Citations

92