The role of zinc, copper, manganese and iron in neurodegenerative diseases

NeuroToxicology, Journal Year: 2019, Volume and Issue: 74, P. 230 - 241

Published: Aug. 1, 2019

Language: Английский

---

Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis

European Journal of Epidemiology, Journal Year: 2018, Volume and Issue: 33(9), P. 789 - 810

Published: July 5, 2018

Language: Английский

---

Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms

Environmental Research, Journal Year: 2021, Volume and Issue: 201, P. 111558 - 111558

Published: July 2, 2021

Language: Английский

---

Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer’s disease: Limitations, and current and future perspectives

Journal of Trace Elements in Medicine and Biology, Journal Year: 2021, Volume and Issue: 67, P. 126779 - 126779

Published: May 15, 2021

Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment and dementia worldwide. The pathobiology has been studied in form several hypotheses, ranging from oxidative stress, amyloid-beta (Aβ) aggregation, accumulation tau forming neurofibrillary tangles (NFT) through metal dysregulation homeostasis, dysfunction cholinergic system, to inflammatory autophagic mechanism. However, none these hypotheses led confirmed diagnostics or approved cure for disease. This review aimed as a basic an encyclopedic short course into metals AD discusses advances chelation strategies developments adopted treatment Since there accumulating evidence role both biometal dyshomeostasis (iron (Fe), copper (Cu), zinc (Zn)) metal-amyloid interactions that lead pathogenesis AD, this focuses on unraveling therapeutic have considered disease, aiming sequester free protein-bound ions reducing cerebral burden. Promising compounds possessing chemically modified moieties evolving multi-target ligands used anti-AD drug candidates are also covered. Several multidirectional multifaceted studies therapeutics show need improved synthesis, screening, analysis be able effectively present chelating drugs. Most limitations their physicochemical properties; some enhance redistribution ions, while others indirectly activate signaling pathways AD. process vivo still needs established design potential bi-functionally well inhibit Aβ aggregation by competing with metal-induced damage neurotoxicity may signal bright end chelation-based

Language: Английский

---

Assessing the contribution of the chemical exposome to neurodegenerative disease

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(5), P. 812 - 821

Published: April 29, 2024

Language: Английский

---

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

Journal of Alzheimer s Disease, Journal Year: 2018, Volume and Issue: 62(3), P. 1369 - 1379

Published: March 13, 2018

It is estimated that by the year 2050 there will be more than 1.5 billion people globally over age of 65 years. Aging associated with changes to a number different cellular processes which are driven variety factors contribute characteristic decline in function seen across multiple physiological domains/tissues elderly (including brain). Importantly, aging also primary risk factor for development neurodegenerative disorders such as Alzheimer’s disease. As such, an urgent need provide greater understanding both pathogenesis and treatment these devastating disorders. One key becomes dysregulated participates directly indirectly age-related dysfunction, metal homeostasis neurochemistry metalloproteins, basic science has been extensively reviewed past. In this review, we focus on human clinical intervention trials have conducted approximately last four decades attempted establish efficacy targeting ions AD.

Language: Английский

---

Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer’s disease, Parkinson’s disease

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 111, P. 765 - 777

Published: Jan. 3, 2019

Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a wide range of genetic, life style environmental factors. A unifying feature Alzheimer's disease (AD) Parkinson's (PD) is the abnormal accumulation processing mutant or damaged intra extracellular proteins; this leads to neuronal vulnerability dysfunction brain. Through detailed review ubiquitin proteasome, mRNA splicing, mitochondrial dysfunction, oxidative stress pathway interrelation on neurodegeneration can improve understanding mechanism. The identified pathways common AD PD nominate promising new targets for further studies, as well biomarkers. These insights suggested would likely provide major stimuli developing unified treatment approaches combat neurodegeneration. More broadly, serve vehicles integrating findings from diverse studies evidence examined provides brief overview current literature significant promoting AD, PD. Additionally, these suggest that biomarkers strategies may require simultaneous targeting multiple components.

Language: Английский

---

Current Advances in The Development of Novel Polymeric Nanoparticles for The Treatment of Neurodegenerative Diseases

Nanomedicine, Journal Year: 2020, Volume and Issue: 15(12), P. 1239 - 1261

Published: May 1, 2020

Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions CNS delivery imposed by blood–brain barrier, and thus be instrumental in preclinical discovery therapeutic ND Polymeric nanoparticles (PNPs) have shown great potential versatility encapsulate several compounds simultaneously controlled drug-delivery systems target them deepest brain regions. Here, we critically review recent advances development drugs incorporated into PNPs summarize molecular changes functional effects achieved models most common disorders. We also briefly discuss many challenges remaining translate these findings technological successfully current clinical settings.

Language: Английский

---

Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

Antioxidants, Journal Year: 2020, Volume and Issue: 9(9), P. 901 - 901

Published: Sept. 22, 2020

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary cause remains elusive, although combination of different causal factors cannot be ruled out. There no cure, and prognosis poor. Most patients with ALS die due to disease-related complications, such as respiratory failure, within three years diagnosis. While the underlying mechanisms are unclear, cell types (microglia, astrocytes, macrophages T subsets) appear play key roles in pathophysiology Neuroinflammation oxidative stress pave way leading neurodegeneration MN death. ALS-associated mitochondrial dysfunction occurs at levels, these organelles involved mechanism Molecular cellular interactions presented here sequential cascade events. Based on our present knowledge, discussion leads idea that feasible therapeutic strategies should focus interfering disease steps.

Language: Английский

---

Technological advances in electrochemical biosensors for the detection of disease biomarkers

Biomedical Engineering Letters, Journal Year: 2021, Volume and Issue: 11(4), P. 309 - 334

Published: Aug. 27, 2021

Language: Английский

---