Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders

Experimental Neurology, Journal Year: 2017, Volume and Issue: 299, P. 241 - 251

Published: July 8, 2017

Language: Английский

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Neuro-toxic and Reproductive Effects of BPA

Current Neuropharmacology, Journal Year: 2019, Volume and Issue: 17(12), P. 1109 - 1132

Published: July 30, 2019

Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. It has recognized activity as an endocrine-disrupting chemical and suspected roles a neurological reproductive toxicant. interferes in steroid signaling, induces oxidative stress, affects gene expression epigenetically. Gestational, perinatal neonatal exposures to BPA affect developmental processes, including brain development gametogenesis, with consequences on functions, behavior, fertility.This review critically analyzes recent findings neuro-toxic effects (and its analogues), focus neuronal differentiation, synaptic plasticity, glia microglia activity, cognitive central local control reproduction.BPA potential human health hazard associated gestational, peri- exposure. Beginning BPA's disposition, this summarizes neurotoxicity analogues, neuroinflammation, neuro-degeneration, impairment abilities. Furthermore, it reports along HPG axis, hypothalamic Gonadotropin Releasing Hormone (GnRH), reproduction both sexes successful pregnancy.BPA analogues impair axis function, reproduction, fertility. Contrasting results have emerged animal models human. Thus, further studies are needed better define their safety levels. This offers new insights these issues aim find "fil rouge", if any, that characterize mechanism action outcomes function reproduction.

Language: Английский

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Preventing chemical contaminants in food: Challenges and prospects for safe and sustainable food production

Food Control, Journal Year: 2023, Volume and Issue: 155, P. 110040 - 110040

Published: Aug. 14, 2023

Human exposure to chemical contaminants in food has resulted into various health related problems. To prevent and mitigate hazardous food, it is imperative understand the sources resultant problems when exposed. The article, therefore, brings light issue of contamination which become a growing concern due its potential harm human health. This line with United Nations' sustainable development goal number three, seeks substantial reduction illnesses from by 2030. It covers range topics, including contamination, that can arise these contaminants, presence naturally occurring food. article emphasizes production process, processing, packaging, transportation, storage, greatly contribute contamination. suggests appropriate legislative measures, along strong surveillance enforcement, help reduce amount achieve this, advocates for continued minimal There need consider economic impact diseases caused toxic global sustainability best practices goals. Finally, adopting around world, we bridge knowledge gaps provide benefits developing countries.

Language: Английский

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Maternal immune activation in neurodevelopmental disorders

Developmental Dynamics, Journal Year: 2017, Volume and Issue: 247(4), P. 588 - 619

Published: Dec. 11, 2017

Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) neurodevelopmental disorders such as autism spectrum disorder (ASD) schizophrenia. The mechanisms through which MIA increases the risk have become subject intensive research. This review aims to describe how dysregulation microglial function may link pathologies. We also summarize current in animal models MIA. Developmental Dynamics 247:588–619, 2018 . © 2017 Wiley Periodicals, Inc.

Language: Английский

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Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner

Frontiers in Synaptic Neuroscience, Journal Year: 2017, Volume and Issue: 9

Published: May 30, 2017

Microglia are the resident immune cells of brain, important for normal neural development in addition to host defense response inflammatory stimuli. Air pollution is one most pervasive and harmful environmental toxicants modern world, several large scale epidemiological studies have recently linked prenatal air exposure with an increased risk neurodevelopmental disorders such as autism spectrum disorder (ASD). Diesel exhaust particles (DEP) a primary toxic component pollution, markedly activate microglia vitro vivo adult rodents. We demonstrated that DEP mice, i.e., pregnant dams throughout gestation, results persistent vulnerability behavioral deficits offspring, especially males, which intriguing given greater incidence ASD males females (∼4:1). Moreover, there striking upregulation toll-like receptor (TLR) 4 gene expression within brains same this primarily microglia. Here we explored impact gestational or vehicle on microglial morphology developing male female mice. cytokine protein altered microglia, consistent activation delay maturation, only embryonic mice; these effects were dependent TLR4. also cortical volume at day (E)18, switched decreased by post-natal (P)30 suggesting stem cell niche. Consistent hypothesis, found microglial-neuronal interactions offspring received compared all other groups. Taken together, data suggest mechanism toxins may affect long-term function, thereby contribute disorders.

Language: Английский

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A highly sensitive impedimetric aptasensor for the selective detection of acetamiprid and atrazine based on microwires formed by platinum nanoparticles

Biosensors and Bioelectronics, Journal Year: 2017, Volume and Issue: 101, P. 268 - 274

Published: Oct. 16, 2017

Language: Английский

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Biomass-derived chemical substitutes for bisphenol A: recent advancements in catalytic synthesis

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(17), P. 6329 - 6363

Published: Jan. 1, 2020

Rigid diols catalytically produced from biomass derivatives have been proposed as bisphenol A functional replacements.

Language: Английский

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Plastics derived endocrine‐disrupting compounds and their effects on early development

Birth Defects Research, Journal Year: 2020, Volume and Issue: 112(17), P. 1308 - 1325

Published: June 1, 2020

Abstract Despite the fact that estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health plastics recommend measure impacts endocrine‐disrupting compounds (EDCs) such as (BPA, BPS, BPF), bis(2‐ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure these utero may program diseases testis, prostate, kidney abnormalities immune system, cause tumors, uterine hemorrhage during pregnancy polycystic ovary. These also control processes epigenetic transgenerational inheritance adult‐onset by modulating DNA methylation epimutations reproductive cells. early developmental stage is most susceptible window for genomic programming. critical stages events normal lie between many transitions occurring spermatogenesis, egg fertilization fully formed fetus. As cells begin grow differentiate, there are balances hormones, protein synthesis. Data emerging how plastic‐derived affect embryogenesis, placentation feto‐placental development since pregnant women unborn fetuses often exposed factors preconception throughout gestation. Impaired ultimately influences fetal outcomes at center disorders contributes an independent risk factor adult chronic diseases. This review will summarize current status exposure plastic derived EDCs growth, gene expression, angiogenic activities process their possible outcomes.

Language: Английский

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Environment matters: microglia function and dysfunction in a changing world

Current Opinion in Neurobiology, Journal Year: 2017, Volume and Issue: 47, P. 146 - 155

Published: Nov. 6, 2017

Language: Английский

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Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2017, Volume and Issue: 122(1), P. 38 - 45

Published: Aug. 26, 2017

Endocrine-disrupting chemicals (EDCs) are man-made that interfere with hormonal signalling pathways. They used in, for example, production of common household materials, in resin-based medical supplies and pesticides. Thus, they environmentally ubiquitous human beings wildlife exposed to them on a daily basis. Early-life exposure EDCs has been associated later-life adversities such as obesity, diabetes cancer. Mechanisms underlying associations unknown but likely be mediated by epigenetic changes induced EDCs. Epigenetics is the study gene function heritable do not entail change DNA sequence. have shown affect marks methylation histone modifications. The scope this article was review today's knowledge about mechanisms involved EDC-induced discuss how could designing novel methods addressing effects

Language: Английский

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