The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(11), P. 3425 - 3425

Published: Nov. 1, 2018

Environmental epigenetics describes how environmental factors affect cellular and, hence, human health. Epigenetic marks alter the spatial conformation of chromatin to regulate gene expression. with epigenetic effects include behaviors, nutrition, and chemicals industrial pollutants. mechanisms are also implicated during development in utero at level, so exposures may harm fetus by impairing epigenome developing organism modify disease risk later life. By contrast, bioactive food components trigger protective modifications throughout life, early life nutrition being particularly important. Beyond their genetics, overall health status an individual be regarded as integration many signals starting gestation acting through modifications. This review explores environment affects disease, a particular focus on cancer. Understanding molecular behavior, nutrients, pollutants might relevant for preventative strategies personalized heath programs. Furthermore, restoring differentiation, drugs could represent potential strategy treatment diseases including

Language: Английский

---

Pesticides: formulants, distribution pathways and effects on human health – a review

Toxicology Reports, Journal Year: 2021, Volume and Issue: 8, P. 1179 - 1192

Published: Jan. 1, 2021

Pesticides are commonly used in agriculture to enhance crop production and control pests. Therefore, pesticide residues can persist the environment agricultural crops. Although modern formulations relatively safe non-target species, numerous theoretical experimental data demonstrate that produce long-term negative effects on health of humans animals stability ecosystems. Of particular interest molecular mechanisms mediate start a cascade adverse effects. This is review latest literature consequences contamination crops by residues. In addition, we address issue implicit risks associated with formulations. The pesticides considered context Adverse Outcome Pathway concept.

Language: Английский

---

Endocrine-Disrupting Chemicals and Disease Endpoints

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5342 - 5342

Published: March 10, 2023

Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and been shown to interfere with physiological especially by disrupting the hormone balance. During last few decades, EDCs affect reproductive, neurological, metabolic development function even stimulate tumor growth. EDC exposure during can disrupt normal patterns alter susceptibility disease. Many endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, phthalates. These compounds gradually elucidated as risk factors for many diseases, such neural, diseases cancers. Endocrine disruption has spread wildlife species that are connected food chains. Dietary uptake represents an important source of exposure. Although represent a public health concern, relationship specific mechanism between remain unclear. This review focuses disease-EDC disease endpoints associated endocrine better understanding EDCs-disease elucidates new prevention/treatment opportunities screening methods.

Language: Английский

---

Glyphosate and the key characteristics of an endocrine disruptor: A review

Chemosphere, Journal Year: 2020, Volume and Issue: 270, P. 128619 - 128619

Published: Oct. 19, 2020

Language: Английский

---

Cancer in wildlife: patterns of emergence

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(10), P. 646 - 661

Published: Aug. 16, 2018

Language: Английский

---

Bisphenol A-induced metabolic disorders: From exposure to mechanism of action

Environmental Toxicology and Pharmacology, Journal Year: 2020, Volume and Issue: 77, P. 103373 - 103373

Published: March 19, 2020

Language: Английский

---

Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations

The FASEB Journal, Journal Year: 2023, Volume and Issue: 37(9)

Published: Aug. 29, 2023

Endometriosis is a common estrogen-dependent disorder wherein uterine lining tissue (endometrium) found mainly in the pelvis where it causes inflammation, chronic pelvic pain, pain with intercourse and menses, infertility. Recent evidence also supports systemic inflammatory component that underlies associated co-morbidities, e.g., migraines cardiovascular autoimmune diseases. Genetics environment contribute significantly to disease risk, explosion of omics technologies, underlying mechanisms symptoms are increasingly being elucidated, although novel effective therapeutics for infertility have lagged behind these advances. Moreover, there stark disparities diagnosis, access care, treatment among persons color transgender/nonbinary identity, socioeconomically disadvantaged populations, adolescents, disturbing low awareness health care providers, policymakers, lay public about endometriosis, which, if left undiagnosed under-treated can lead significant fibrosis, infertility, depression, markedly diminished quality life. This review summarizes endometriosis epidemiology, compelling its pathogenesis, pathophysiology age precision medicine, recent biomarker discovery, therapeutic approaches, issues around reproductive justice marginalized populations this spanning past 100 years. As we enter next revolution biomedical research, rich molecular clinical datasets, single-cell omics, population-level data, well positioned benefit from data-driven research leveraging computational artificial intelligence approaches integrating data predicting response medical surgical therapies, prognosis recurrence.

Language: Английский

---

The insulin-like growth factor system: A target for endocrine disruptors?

Environment International, Journal Year: 2020, Volume and Issue: 147, P. 106311 - 106311

Published: Dec. 18, 2020

The insulin-like growth factor (IGF) system is a critical regulator of growth, especially during fetal development, while also playing central role in metabolic homeostasis. Endocrine disruptors (EDs) are ubiquitous compounds able to interfere with hormone action and impact human health. For example, exposure EDs associated decreased birthweight increased incidence disorders. Therefore, the IGF potential target for endocrine disruption. This review summarises state science regarding effects major classes (dioxins dioxin-like compounds, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers, phthalates, perfluoroalkyl substances bisphenol A) on system. Evidence from both experimental models (in vitro vivo) epidemiological studies presented. In addition, possible molecular mechanisms methylation discussed. There large body evidence supporting link between dioxins disruption, but mixed findings have been reported studies. On other hand, although only few animal investigated phthalates system, their negative association levels status has more consistently humans. A still limited. Despite lack some ED linking changes levels, need further research improve reproducibility determine degree risk posed by this clearly an area concern.

Language: Английский

---

Early Life Exposure to Environmentally Relevant Levels of Endocrine Disruptors Drive Multigenerational and Transgenerational Epigenetic Changes in a Fish Model

Frontiers in Marine Science, Journal Year: 2020, Volume and Issue: 7

Published: June 24, 2020

The inland silverside, Menidia beryllina, is a euryhaline fish and model organism in ecotoxicology. We previously showend that exposure to picomolar (ng/L) levels of endocrine disrupting chemicals (EDCs) can cause variety effects M. from changes gene expression phenotypic alterations. Here we explore the potential for early life EDCs modify epigenome silversides, with focus on multi- transgenerational effects. included contaminants emerging concern (the pyrethroid insecticide bifenthrin synthetic progestin levonorgestrel), as well commonly detected estrogen (ethinylestradiol), androgen (trenbolone) at ranging 3 10 ng/L. In multigenerational experiment, exposed parental silversides fertilization until 21 days post hatch (dph). Then assessed DNA methylation patterns three generations (F0, F1, F2) whole body larval using reduced representation bisulfite sequencing (RRBS). found significant ( = 0.05) differences promoter and/or treatment relative controls all indicating both (F1) (F2) were caused by strict inheritance alterations dysregulation epigenetic control mechanisms. Using ontology pathway analyses, enrichment biological processes pathways representative growth development, immune function, reproduction, pigmentation, regulation, stress response repair (including important carcinogenesis). Further, subset potentially EDC responsive genes (EDCRGs) differentially methylated across treatments hormone receptors, involved steroidogenesis, prostaglandin synthesis, sexual methylation, protein metabolism cell signaling, neurodevelopment. analysis EDCRGs provided additional evidence differential inherited offspring EDC-treated animals, sometimes F2 generation was never exposed. These findings show low, environmentally relevant altered are functionally impaired phenotypes documented EDC-exposed animals has affect regulation future fish.

Language: Английский

---

Neighborhood disadvantage and biological aging biomarkers among breast cancer patients

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 30, 2022

Abstract Living in a disadvantaged neighborhood is associated with adverse clinical outcomes among breast cancer patients, but the underlying pathway still unclear. Limited evidence has suggested that accelerated biological aging may play an important role. In this study, using sub-sample of 906 women newly diagnosed at M.D. Anderson, we examined whether levels selected markers (e.g., allostatic load, telomere length, and global DNA methylation) were affected by disadvantage. The Area Deprivation Index was used to determine Based on median ADI national level, study population divided into low high groups. Overall, patients from group more likely be younger non-Hispanic Black than those ( P < 0.001, respectively). They also have higher grade poorly differentiated tumors = 0.029 0.019, For relationship markers, compared group, had load 0.046) lower methylation 0.001). Compared their counterparts, 20% increased 51% less methylation. summary, observed are influenced disadvantage patients.

Language: Английский

---