Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity

Trends in Cognitive Sciences, Journal Year: 2019, Volume and Issue: 23(11), P. 938 - 951

Published: Oct. 6, 2019

Language: Английский

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Apoptosis and its therapeutic implications in neurodegenerative diseases

Clinical Anatomy, Journal Year: 2021, Volume and Issue: 35(1), P. 65 - 78

Published: Sept. 24, 2021

Neurodegenerative disorders are characterized by progressive loss of particular populations neurons. Apoptosis has been implicated in the pathogenesis neurodegenerative diseases, including Parkinson disease, Alzheimer Huntington and amyotrophic lateral sclerosis. In this review, we focus on existing notions relevant to comprehending apoptotic death process, morphological features, mediators regulators cellular apoptosis. We also highlight evidence neuronal Additionally, present potential therapeutic agents that could modify pathway aforementioned diseases delay disease progression. Finally, review clinical trials were conducted evaluate use anti-apoptotic drugs treatment order essential need for early detection intervention humans.

Language: Английский

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Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

Pharmacological Research, Journal Year: 2022, Volume and Issue: 177, P. 106126 - 106126

Published: Feb. 10, 2022

Language: Английский

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MicroRNAs in Alzheimer’s Disease: Diagnostic Markers or Therapeutic Agents?

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: June 18, 2019

MicroRNAs (miRNAs) are small non-coding nucleic acids able to post-transcriptionally regulate gene expression by binding complementary sequences of target messenger RNA (mRNA). It has been estimated that at least 1% the human genome encodes miRNA and every can up 200 mRNAs. These findings suggest dysregulation could be associated with several pathological conditions including central neurological disorders. Alzheimer’s disease (AD) is a neurodegenerative disorder most common cause dementia in elderly. The characteristic symptoms progressive loss memory other cognitive functions due impairment particular types neurons synapses, leading neuronal death. At present, available symptomatic treatments only slow down progression without stopping it. miRNAs widely found within nervous system where they key regulators such as neurite outgrowth, dendritic spine morphology, differentiation synaptic plasticity. This clue for considering crucial molecules studied AD nowadays dysfunction increasingly recognized. In this review, we summarized existing evidence about biomarkers or therapeutic agents. field more advanced terms data, it likely will used successfully near future. Given huge number potentially involved diagnostics, panels specific tasks stage disease, risk prediction progression. therapeutics rapidly developing offers variety solutions. include positive effects related beta-amyloid tau reduction, increased neurons, inhibition apoptosis, protection transformation cellular elements into missing/deficient AD, so on. predictable both areas research carried forward. However, given absence an therapy stop reverse desirable accelerate on

Language: Английский

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MicroRNAs in Alzheimer’s Disease: Function and Potential Applications as Diagnostic Biomarkers

Frontiers in Molecular Neuroscience, Journal Year: 2020, Volume and Issue: 13

Published: Aug. 21, 2020

Alzheimer's disease (AD) is the most common form of dementia. Although incidence AD high, rates diagnosis and treatment are relatively low. Moreover, effective means for still lacking. MicroRNAs (miRNAs, miRs) noncoding RNAs that play regulatory roles by targeting mRNAs. The expression miRNAs conserved, temporal, tissue-specific. Impairment microRNA function closely related to pathogenesis, including beta-amyloid tau hallmarks AD, there evidence some microRNAs differs significantly between healthy people patients. These properties endow them with potential diagnostic therapeutic value in this debilitating disease. This review provides comprehensive information about fuction as well applications biomarkers.

Language: Английский

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Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

Inorganic Chemistry, Journal Year: 2019, Volume and Issue: 58(20), P. 13509 - 13527

Published: June 17, 2019

According to the amyloid cascade hypothesis, metal ions, mainly Cu and Zn bound amyloid-β (Aβ) peptides are implicated in Alzheimer's disease (AD), a widespread neurodegenerative disease. They indeed impact aggregation pathways of Aβ involved catalytic generation reactive oxygen species (ROS) that participate oxidative stress, while stress regarded as two key events AD etiology. ions due their redox ability have been considered be main potential therapeutic targets AD. A considerable number ligands developed order modulate toxicity associated with this context, via disruption Aβ-Cu interaction. Among them, small synthetic peptide scaffolds designed studied for remove from Aβ. Some those able prevent Cu(Aβ)-induced ROS production can modify vitro cellulo. Examples such gathered Viewpoint, function structures discussed respect properties against Cu(Aβ) deleterious fallouts. Nevertheless, beneficial activities most promising detected cellulo not transposed human yet. parameters might explain apparent contradiction concepts consider design "more" efficient thus reported discussed. En passant, Viewpoint sheds light on difficulties comparing results one study another hamper significant advances field.

Language: Английский

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Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a age-related neurodegenerative and major public health concern both in Texas, US Worldwide. This mainly characterized by amyloid-beta (Aβ) phosphorylated Tau (p-Tau) accumulation the brains of patients with AD increasing evidence suggests that these are key biomarkers AD. Both Aβ p-tau can be detected through various imaging techniques (such as positron emission tomography, PET) cerebrospinal fluid (CSF) analysis. The presence individuals, who asymptomatic or have mild cognitive impairment indicate an increased risk developing future. Furthermore, combination often used for more accurate diagnosis prediction progression. Along being disease, it associated other chronic conditions such cardiovascular obesity, depression, diabetes because studies shown comorbid make people vulnerable to In first part this review, we discuss biofluid-based Aβ, p-Tau & plasma could alternative sensitive technique diagnose second part, underlying molecular mechanisms linked how they affect clinical care.

Language: Английский

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Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells

Free Radical Biology and Medicine, Journal Year: 2018, Volume and Issue: 120, P. 114 - 123

Published: March 17, 2018

Language: Английский

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Effect of lncRNA WT1-AS regulating WT1 on oxidative stress injury and apoptosis of neurons in Alzheimer's disease via inhibition of the miR-375/SIX4 axis

Aging, Journal Year: 2020, Volume and Issue: 12(23), P. 23974 - 23995

Published: Nov. 21, 2020

To study the effect of lncRNA WT1-AS on oxidative stress injury (OSI) and apoptosis neurons in Alzheimer's disease (AD) its specific mechanisms related to microRNA-375 (miR-375)/SIX4 axis WT1 expression.After bioinformatic prediction, was found be downregulated Aβ25-35treated SH-SY5Y cells, overexpression inhibited expression. could target miR-375 promote bound SIX4, SIX4 OSI apoptosis, while or silencing reversed apoptosis. In vivo experiments revealed that improved learning/memory abilities AD mice.Overexpression can inhibit miR-375/SIX4 axis, neuronal by inhibiting expression.Related lncRNAs were identified, downstream targets predicted. WT1-AS, WT1, expression detected a cell model induced Aβ25-35. The binding with further confirmed. Adenosine triphosphate (ATP), reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) lactate dehydrogenase (LDH) activities, levels tested after mitochondrial membrane potential observation. Learning/memory mouse model.

Language: Английский

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Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations

ACS Chemical Neuroscience, Journal Year: 2021, Volume and Issue: 12(3), P. 506 - 516

Published: Jan. 25, 2021

The formation of amyloid β (1-42) (Aβ42) oligomers is considered to be a critical step in the development Alzheimer's disease (AD). However, mechanism underlying this process at physiologically low concentrations Aβ42 remains unclear. We have previously shown that assemble such monomer vitro on phospholipid membranes. hypothesized membrane composition factor controlling aggregation process. Accumulation cholesterol membranes associated with AD development, suggesting insertion into may initiate aggregation, regardless concentration. used atomic force microscopy (AFM) test hypothesis and directly visualize surface lipid bilayer depending presence. Time-lapse AFM imaging unambiguously demonstrates significantly enhances nanomolar Quantitative analysis data shows both number their sizes grow when present. Importantly, dynamic, so aggregates assembled can dissociate from bulk solution. Computational modeling demonstrated containing had an elevated affinity Aβ42. Moreover, monomers adopted aggregation-prone conformations present fibrils. results lead model for on-surface which self-assembly Aβ controlled by cellular

Language: Английский

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