Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease DOI Creative Commons

Jing Zhou,

Alfie Wearn, Julia Huck

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(19), P. e1973232024 - e1973232024

Published: Feb. 22, 2024

Elevated iron deposition in the brain has been observed older adult humans and persons with Alzheimer's disease (AD), associated lower cognitive performance. We investigated impact of deposition, its topographical distribution across hippocampal subfields segments (anterior, posterior) measured along longitudinal axis, on episodic memory a sample cognitively unimpaired adults at elevated familial risk for AD ( N = 172, 120 females, 52 males; mean age 68.8 ± 5.4 years). MRI-based quantitative susceptibility maps were acquired to derive estimates deposition. The Mnemonic Similarity Task was used measure pattern separation completion, two hippocampally mediated processes. Greater load higher completion scores, both indicators poorer memory. Examination levels within long axis revealed topographic specificity. Among here, posterior CA1 most robustly negatively fidelity representations. This association remained after controlling volume context normal performance standard neuropsychological measures. These findings reveal that is not uniform hippocampus. Both as well spatial distribution, must be taken into account when examining relationship between AD.

Language: Английский

Neurogenesis in aging and age-related neurodegenerative diseases DOI Creative Commons

Luka Čulig,

Xixia Chu,

Vilhelm A. Bohr

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 78, P. 101636 - 101636

Published: April 29, 2022

Language: Английский

Citations

119
The neurobiology of human fear generalization: meta-analysis and working neural model DOI
Ryan Webler, Hannah Berg,

Kimberly Fhong

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 128, P. 421 - 436

Published: July 6, 2021

Language: Английский

Citations

116
Neurobiology and systems biology of stress resilience DOI
Raffaël Kalisch, Scott J. Russo,

Marianne B. Müller

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(3), P. 1205 - 1263

Published: March 14, 2024

Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.

Language: Английский

Citations

31
The 'middle-aging' brain DOI Creative Commons
Sebastian Dohm-Hansen, Jane A. English,

Aonghus Lavelle

et al.

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 259 - 272

Published: March 19, 2024

Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle could mark a shift in aging. We review emerging evidence on multiple levels analysis indicating midlife is defined by unique central peripheral processes shape future trajectories health. Informed developments aging lifespan studies humans animal models, we highlight utility modeling non-linear changes study samples with wide subject ranges distinguish stage-specific from those acting linearly throughout lifespan.

Language: Английский

Citations

21
Mapping and modeling age-related changes in intrinsic neural timescales DOI Creative Commons
Kaichao Wu, Leonardo L. Gollo

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 3, 2025

Intrinsic timescales of brain regions exhibit heterogeneity, escalating with hierarchical levels, and are crucial for the temporal integration external stimuli. Aging, often associated cognitive decline, involves progressive neuronal synaptic loss, reshaping structure dynamics. However, impact these structural changes on coding in aging remains unclear. We mapped intrinsic gray matter volume (GMV) using magnetic resonance imaging (MRI) young elderly adults. found shorter across multiple large-scale functional networks cohort, a significant positive association between GMV. Additionally, age-related decline performance visual discrimination tasks was linked to reduction cuneus. To explain shifts, we developed an age-dependent spiking neuron network model. In younger subjects, were near critical branching regime, while subjects had fewer neurons synapses, pushing dynamics toward subcritical regime. The model accurately reproduced empirical results, showing longer adults due slowing down. Our findings reveal how may drive alterations dynamics, offering testable predictions informing possible interventions targeting decline. MRI data computational modeling shifts shedding light its effects processes, potential mechanisms underlying neurological vulnerabilities.

Language: Английский

Citations

2
Understanding Image Memorability DOI Creative Commons
Nicole C. Rust, Vahid Mehrpour

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(7), P. 557 - 568

Published: May 5, 2020

Language: Английский

Citations

90
Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO‐1/NQO1 pathway DOI
Qiang Lu, Ying Zhang, Chao Zhao

et al.

Journal of Applied Toxicology, Journal Year: 2021, Volume and Issue: 42(4), P. 694 - 705

Published: Oct. 21, 2021

Abstract Disordered copper metabolism has been suggested to occur several neurological conditions, including Alzheimer's disease and Parkinson's disease. However, the underlying mechanism was still unclear. This might link copper‐induced hippocampal neuronal apoptosis decrease in neurons viability. Our vitro experiment showed exposure induced oxidative stress promoted of HT22 murine cell. Mechanistically, we found copper, on one hand, prevented phosphorylation cAMP response element binding protein (CREB) expression its downstream target Brain‐derived neurotrophic factor (BDNF), mitochondrial membrane potential Bcl‐2/Bax ratio; other reactive oxygen species (ROS), lipid peroxidation, reduced antioxidant enzyme activity GSH‐Px. Copper‐induced damage further decreased CREB, Bcl‐2, enhanced Bax, accelerated dissociation keap1‐Nrf2 complex, nuclear translocation Nrf2, stimulate molecules HO‐1 NQO1. In conclusion, inhibited pCREB/BDNF signaling pathway by prevent CREB from phosphorylation, that not only neuroprotective pathways apoptosis, but activated protection signals Nrf2/HO‐1/NQO1 pathway.

Language: Английский

Citations

64
Neurodegenerative disease of the brain: a survey of interdisciplinary approaches DOI Creative Commons

Franca Davenport,

John Gallacher, Zoe Kourtzi

et al.

Journal of The Royal Society Interface, Journal Year: 2023, Volume and Issue: 20(198)

Published: Jan. 1, 2023

Neurodegenerative diseases of the brain pose a major and increasing global health challenge, with only limited progress made in developing effective therapies over last decade. Interdisciplinary research is improving understanding these this article reviews such approaches, particular emphasis on tools techniques drawn from physics, chemistry, artificial intelligence psychology.

Language: Английский

Citations

33
Predictions transform memories: How expected versus unexpected events are integrated or separated in memory DOI Creative Commons
Oded Bein, Camille Gasser, Tarek Amer

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105368 - 105368

Published: Aug. 22, 2023

Language: Английский

Citations

27
Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan. DOI Creative Commons
Helena M. Gellersen, Jessica McMaster, Ayat Abdurahman

et al.

Journal of Experimental Psychology General, Journal Year: 2024, Volume and Issue: 153(1), P. 200 - 223

Published: Jan. 1, 2024

Aging results in less detailed memories, reflecting reduced fidelity of remembered compared to real-world representations. We tested whether poorer representational across perception, short-term memory (STM), and long-term (LTM) are among the earliest signs cognitive aging. Our paradigm probed target-lure object mnemonic discrimination precision object-location binding. Across lifespan, deficits were observed midlife when stimulus representations required for perceptual short/long-term forced choice discrimination. A continuous metric source combined with computational modeling demonstrated that errors STM LTM middle-aged adults largely driven by a loss retrieved not necessarily forgetting. On trial-by-trial basis, item spatial information was more tightly bound this association being unaffected age. Standard neuropsychological tests without demands on quality (digit span, verbal learning) sensitive age effects than precision. Perceptual predicted Neuropsychological proxies prefrontal executive functions correlated STM, but fidelity. Conversely, indicators hippocampal integrity both LTM, suggesting partially dissociable mechanisms interindividual variability These findings suggest is hallmark aging can be from onward. Continuous tasks may promising early detection subtle age-related decline. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Language: Английский

Citations

10