Journal of Neuroscience,
Journal Year:
2018,
Volume and Issue:
38(44), P. 9433 - 9445
Published: Oct. 31, 2018
The
ability
to
anticipate
and
respond
appropriately
the
challenges
opportunities
present
in
our
environments
is
critical
for
adaptive
behavior.
Recent
methodological
innovations
have
led
substantial
advances
understanding
of
neurocircuitry
supporting
such
motivated
behavior
adulthood.
However,
neural
circuits
cognitive
processes
that
enable
threat-
reward-motivated
undergo
substantive
changes
over
course
development,
these
are
less
well
understood.
In
this
article,
we
highlight
recent
research
human
animal
models
demonstrating
how
developmental
prefrontal-subcortical
give
rise
corresponding
processing
threats
rewards
from
infancy
We
discuss
trajectories
altered
by
experiential
factors,
as
early-life
stress,
relevance
onset
treatment
psychiatric
disorders
characterized
dysregulation
Brain Sciences,
Journal Year:
2019,
Volume and Issue:
9(4), P. 76 - 76
Published: March 29, 2019
Emotion
regulation
skills
develop
substantially
across
adolescence,
a
period
characterized
by
emotional
challenges
and
developing
regulatory
neural
circuitry.
Adolescence
is
also
risk
for
the
new
onset
of
anxiety
depressive
disorders,
psychopathologies
which
have
long
been
associated
with
disruptions
in
positive
negative
emotions.
This
paper
reviews
current
understanding
role
disrupted
emotion
adolescent
depression,
describing
findings
from
self-report,
behavioral,
peripheral
psychophysiological,
measures.
Self-report
studies
robustly
identified
associations
between
dysregulation
depression.
Findings
behavioral
psychophysiological
are
mixed,
some
suggestion
specific
impairments
reappraisal
anxiety.
Results
neuroimaging
broadly
implicate
altered
functioning
amygdala-prefrontal
cortical
circuitries,
although
again,
mixed
regarding
patterns
functioning.
Future
work
may
benefit
focusing
on
designs
that
contrast
effects
strategies,
isolate
changes
reactivity.
Approaches
to
improve
treatments
based
empirical
evidence
adolescents
discussed.
intervention
might
consider
training
measurement
strategies
better
understand
as
treatment
mechanism.
Nicotine & Tobacco Research,
Journal Year:
2020,
Volume and Issue:
23(3), P. 415 - 425
Published: Sept. 4, 2020
Abstract
Introduction
The
prevalence
of
electronic
cigarette
(EC)
use
has
risen
dramatically
among
adolescents
and
young
adults
(AYA,
ages
12–26)
over
the
past
decade.
Despite
extensive
established
relationships
between
combustible
mental
health
problems,
comorbidities
EC
remain
unclear.
Aims
Methods
To
provide
a
systematic
review
existing
literature
on
AYA.
Database
searches
using
search
terms
related
to
EC,
AYA,
identified
1168
unique
articles,
87
which
prompted
full-text
screening.
Multiple
authors
extracted
data,
applied
Effective
Public
Health
Practice
Project
Quality
Assessment
Tool
evaluate
evidence,
synthesized
findings.
Results
Forty
articles
met
eligibility
criteria
(n
=
24
predominantly
adolescent
16
adult).
Analyses
yielded
three
main
categories
focus:
internalizing
disorders
(including
depression,
anxiety,
suicidality,
eating
disorders,
post-traumatic
stress
disorder),
externalizing
(attention-deficit/hyperactivity
disorder
conduct
transdiagnostic
concepts
(impulsivity
perceived
stress).
Significant
methodological
limitations
were
noted.
Conclusions
Youth
is
associated
with
greater
problems
(compared
nonuse)
across
several
domains,
particularly
adolescents.
Because
many
studies
are
cross-sectional,
directionality
remains
uncertain.
Well-designed
longitudinal
investigate
long-term
sequelae
needed.
Implications
recent
demonstrate
variety
AYA
use,
Mental
generally
parallel
those
few
exceptions.
Future
prevention
treatment
strategies
may
be
enhanced
by
addressing
health.
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: Feb. 5, 2018
A
central
aim
of
human
neuroscience
is
understanding
the
neurobiology
cognition
and
behavior.
Although
we
have
made
significant
progress
towards
this
goal,
reliance
on
group-level
studies
developed
adult
brain
has
limited
our
ability
to
explain
population
variability
developmental
changes
in
neural
circuitry
In
review,
suggest
that
predictive
modeling,
a
method
for
predicting
individual
differences
behavior
from
features,
can
complement
descriptive
approaches
provide
new
ways
account
variability.
Highlighting
outsized
scientific
clinical
benefits
prediction
populations
including
adolescence,
show
brain-based
models
are
already
providing
insights
adolescent-specific
risk-related
behaviors.
Together
with
large-scale
neuroimaging
datasets
complementary
analytic
approaches,
modeling
affords
us
opportunity
obligation
identify
novel
treatment
targets
individually
tailor
course
interventions
psychopathologies
impact
so
many
young
people
today.
Translational Psychiatry,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Oct. 6, 2023
Abstract
Substance
use
in
adolescence
is
a
known
risk
factor
for
the
development
of
neuropsychiatric
and
substance
disorders
adulthood.
This
part
due
to
fact
that
critical
aspects
brain
occur
during
adolescence,
which
can
be
altered
by
drug
use.
Despite
concerted
efforts
educate
youth
about
potential
negative
consequences
use,
initiation
remains
common
amongst
adolescents
world-wide.
Additionally,
though
there
has
been
substantial
research
on
topic,
many
questions
remain
predictors
adolescent
In
following
review,
we
will
highlight
some
most
recent
literature
neurobiological
behavioral
effects
rodents,
non-human
primates,
humans,
with
specific
focus
alcohol,
cannabis,
nicotine,
interactions
between
these
substances.
Overall,
consumption
substances
produce
long-lasting
changes
across
variety
structures
networks
have
enduring
behavior,
emotion,
cognition.
Proceedings of the National Academy of Sciences,
Journal Year:
2021,
Volume and Issue:
118(28)
Published: July 6, 2021
Significance
Here,
we
describe
age-dependent
shifts
in
the
macroscale
organization
of
cortex
childhood
and
adolescence.
The
characterization
functional
connectivity
patterns
children
revealed
an
overarching
organizational
framework
anchored
within
unimodal
cortex,
between
somatosensory/motor
visual
regions.
Conversely,
adolescents,
observed
a
transition
into
adult-like
gradient,
situating
default
network
at
opposite
end
spectrum
from
primary
This
spatial
emerged
gradually
with
age,
reaching
sharp
inflection
point
to
These
data
reveal
developmental
change
motif
first
dominated
by
distinction
sensory
motor
systems
then
balanced
through
interactions
later-maturing
aspects
association
that
support
more
abstract
cognitive
functions.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(8), P. 3171 - 3181
Published: Aug. 1, 2023
Abstract
Most
mental
disorders
have
a
typical
onset
between
12
and
25
years
of
age,
highlighting
the
importance
this
period
for
pathogenesis,
diagnosis,
treatment
ill-health.
This
perspective
addresses
interactions
risk
protective
factors
brain
development
as
key
pillars
accounting
emergence
psychopathology
in
youth.
Moreover,
we
propose
that
novel
approaches
towards
early
diagnosis
interventions
are
required
reflect
evolution
emerging
psychopathology,
service
models,
knowledge
exchange
science
practitioners.
Taken
together,
transformative
intervention
paradigm
research
clinical
care
could
significantly
enhance
health
young
people
initiate
shift
prevention
severe
disorders.
Journal of Psychiatric Research,
Journal Year:
2024,
Volume and Issue:
174, P. 263 - 274
Published: April 18, 2024
Emotion
dysregulation
(ED),
the
difficulty
in
modulating
which
emotions
are
felt,
and
when
how
they
expressed
or
experienced,
has
been
implicated
an
array
of
psychological
disorders.
Despite
potentially
different
manifestations
depending
on
disorder,
this
symptom
is
emerging
as
a
transdiagnostic
construct
that
can
should
be
targeted
early,
given
associations
with
various
maladaptive
behaviors
early
childhood
adolescence.
As
such,
our
goal
was
to
investigate
psychotherapeutic
interventions
used
address
ED
gauge
their
effectiveness,
safety,
potential
mechanisms
across
populations.
This
umbrella
systematic
review,
pre-registered
under
PROSPERO
(registration:
CRD42023411452),
consolidates
evidence
from
reviews
meta-analyses
targeting
ED,
accordance
PRISMA
guidelines.
Our
synthesis
quantitative
qualitative
21
(including
11
meta-analyses)
points—with
moderate
overall
risk
bias—to
effectiveness
Dialectical
Behavior
Therapy
Cognitive
Behavioral
reducing
wide
range
adult
psychiatric
patients
healthy
participants.
Similar
results
have
emerged
other
less
extensively
researched
methods
well.
However,
adolescents
children
sparse,
highlighting
need
for
additional
research
tailor
these
unique
challenges
younger
populations
diverse
externalizing
internalizing
These
demonstrated
advantages
psychotherapy
underscore
specifically
designed
issue
directly,
particularly
high-risk
individuals.
In
individuals,
core
dimensions
may
mitigate
emergence
full-blown
Future
mediating
factors,
durability
intervention
effects,
exploration
understudied
enhance
prevention
treatment
efficiency,
enhancing
quality
life
those
affected
by
varied
ED.