Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence DOI Creative Commons

Samuel T. Vielee,

John Pierce Wise

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 500 - 500

Published: March 16, 2023

Advancements in modern medicine have improved the quality of life across globe and increased average lifespan our population by multiple decades. Current estimates predict 2030, 12% global will reach a geriatric age live another 3-4 This swelling place critical stress on healthcare infrastructures due to accompanying increases age-related diseases comorbidities. While much research focused long-lived individuals seeks answer questions regarding how healthier, there is deficit investigating what aspects lives accelerate or exacerbate aging. In particular, heavy metals are recognized as significant threat human health with links plethora diseases, widespread exposures from occupational, medical, environmental settings. We believe ought be classified class gerontogens (i.e., chemicals that biological aging cells tissues). Gerontogens may best studied through their effects "Hallmarks Aging", nine physiological hallmarks demonstrated occur aged cells, tissues, bodies. Evidence suggests cellular senescence-a permanent growth arrest cells-is one most pertinent useful indicator tissues. Here, we discuss roles brain briefly general, then expand upon observations for contributing neurodegenerative disorders. particularly emphasize senescence diseases. Finally, inducing senescence. The glaring lack knowledge about gerontogenic mechanisms necessitates greater field, especially context crisis.

Language: Английский

Influence of heavy metals in Parkinson’s disease: an overview DOI
Balachandar Vellingiri,

Atchaya Suriyanarayanan,

Kripa Susan Abraham

et al.

Journal of Neurology, Journal Year: 2022, Volume and Issue: 269(11), P. 5798 - 5811

Published: July 28, 2022

Language: Английский

Citations

41
Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders DOI Creative Commons

Elodie Kip,

Louise C. Parr‐Brownlie

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Feb. 15, 2023

Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people's health wellbeing. This focus has created lifestyles with high stress levels, associated overconsumption of unhealthy foods little exercise, which negatively affect lives, subsequently lead to development pathologies, including neurodegenerative psychiatric disorders. Prioritizing a healthy lifestyle maintain wellbeing may slow onset or reduce severity pathologies. It is win-win for everyone; individuals. A balanced increasingly being adopted globally, many doctors encouraging meditation prescribing non-pharmaceutical interventions treat depression. In disorders, inflammatory response system brain (neuroinflammation) activated. Many risks factors now known be linked neuroinflammation such as stress, pollution, saturated trans fat diet. On other hand, studies habits anti-inflammatory products lower levels reduced risk Sharing protective critical so that individuals can make informed choices promote positive aging throughout their lifespan. Most strategies manage diseases palliative because neurodegeneration been progressing silently decades before symptoms appear. Here, we preventing by adopting an integrated "healthy" approach. review summarizes role

Language: Английский

Citations

39
A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson’s disease: beneficial or detrimental effects DOI
Mohammed Alrouji, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(2), P. 673 - 688

Published: March 24, 2023

Language: Английский

Citations

28
Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment DOI
Lokesh Murumulla,

Lakshmi Jaya Madhuri Bandaru,

Suresh Challa

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(4), P. 1411 - 1427

Published: July 18, 2023

Language: Английский

Citations

24
Low-level, chronic ingestion of lead and cadmium: The unspoken danger for at-risk populations DOI

Jordyn Ann Howard,

Laurent David, François Lux

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135361 - 135361

Published: July 28, 2024

Language: Английский

Citations

13
Luteolin attenuates cadmium neurotoxicity by suppressing glial inflammation and supporting neuronal survival DOI

Hui-Yong Ma,

Jing Wang, Jun Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114406 - 114406

Published: March 10, 2025

Language: Английский

Citations

1
Molecular Mechanisms of Environmental Metal Neurotoxicity: A Focus on the Interactions of Metals with Synapse Structure and Function DOI Creative Commons
Asunción Carmona, Stéphane Roudeau, Richard Ortega

et al.

Toxics, Journal Year: 2021, Volume and Issue: 9(9), P. 198 - 198

Published: Aug. 27, 2021

Environmental exposure to neurotoxic metals and metalloids such as arsenic, cadmium, lead, mercury, or manganese is a global health concern affecting millions of people worldwide. Depending on the period over lifetime, environmental can alter neurodevelopment, neurobehavior, cognition cause neurodegeneration. There increasing evidence linking metal contaminants etiology neurological diseases in early life (e.g., autism spectrum disorder) late Alzheimer's disease). The known main molecular mechanisms metal-induced toxicity cells are generation reactive oxygen species, interaction with sulfhydryl chemical groups proteins cysteine), competition toxic binding sites essential Fe, Cu, Zn). In neurons, these interactions functions neurotransmitter receptors, cytoskeleton scaffolding synaptic proteins, thereby disrupting structure function. Loss connectivity may precede more drastic alterations this article, we will review neurotoxicity.

Language: Английский

Citations

56
Metal Exposure and Risk of Parkinson Disease: A Systematic Review and Meta-Analysis DOI Creative Commons
Yujia Zhao,

Anushree Ray,

Lützen Portengen

et al.

American Journal of Epidemiology, Journal Year: 2023, Volume and Issue: 192(7), P. 1207 - 1223

Published: April 6, 2023

Abstract Metal exposure has been suggested as a possible environmental risk factor for Parkinson disease (PD). We searched the PubMed, EMBASE, and Cochrane databases to systematically review literature on relationship between metal PD examine overall quality of each study assessment method. A total 83 case-control studies 5 cohort published during period 1963–July 2021 were included, which 73 graded being low or moderate quality. Investigators in 69 adopted self-reported biomonitoring after diagnosis approaches. The meta-analyses showed that concentrations copper iron serum zinc either plasma lower, while magnesium CSF hair higher, among cases compared with controls. Cumulative lead levels bone found be associated increased PD. did not find associations other metals current level evidence is limited, biases from methodological limitations cannot ruled out. High-quality assessing before onset are needed improve our understanding role etiology

Language: Английский

Citations

19
Distribution of Iron, Copper, Zinc and Cadmium in Glia, Their Influence on Glial Cells and Relationship with Neurodegenerative Diseases DOI Creative Commons
Aleksandra Górska,

Agnieszka Markiewicz-Gospodarek,

Renata Markiewicz

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(6), P. 911 - 911

Published: June 5, 2023

Recent data on the distribution and influence of copper, zinc cadmium in glial cells are summarized. This review also examines relationship between those metals their role neurodegenerative diseases like Alzheimer disease, multiple sclerosis, Parkinson disease Amyotrophic lateral which have become a great challenge for today’s physicians. The studies suggest that among cells, iron has highest concentration oligodendrocytes, copper astrocytes glia hippocampus cortex. Previous shown neurotoxic effects manganese, while can bidirectional effect, i.e., but neuroprotective depending dose state. point to association with neurodegeneration through modulation protein aggregation. Metals accumulate brain aging may be associated age-related diseases.

Language: Английский

Citations

19
Dietary Copper Intake and Risk of Parkinson’s Disease: a Cross-sectional Study DOI Creative Commons
Zhaohao Zeng, Yanmei Cen,

Lijiao Xiong

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(3), P. 955 - 964

Published: July 18, 2023

Copper is an essential trace element for the human body. The epidemiological evidence association of dietary intake copper with risk Parkinson's disease (PD) limited. We conducted evaluation cross-sectional data gathered from National Health and Nutrition Examination Surveys spanning 2007 to 2018, which comprised a total 17,948 participants. To discern distinct characteristics participants, we performed univariate analysis utilized 1:2 ratio propensity score matching method minimize effects selection bias. employed weighted as well three multivariate logistic regression models both prior following matching, aim examining between PD risk. Finally, used restricted cubic spline (RCS) methodology in order investigate possible non-linear relationships. Furthermore, subgroup was undertaken elicit further understanding concerning PD. A negative correlation resulted models, matching. Our findings demonstrate that there nonlinear, dose-dependent relationship PD, according our RCS analysis. In analysis, identified important protective factor individuals who were non-Hispanic White, unmarried, had completed higher education. Dietary associated Supplementation may have potentially beneficial effects.

Language: Английский

Citations

19