Neurophotonics,
Journal Year:
2023,
Volume and Issue:
10(01)
Published: Jan. 24, 2023
Diffuse
correlation
spectroscopy
(DCS)
has
emerged
as
a
versatile,
noninvasive
method
for
deep
tissue
perfusion
assessment
using
near-infrared
light.
A
broad
class
of
applications
is
being
pursued
in
neuromonitoring
and
beyond.
However,
technical
limitations
the
technology
originally
implemented
remain
barriers
to
wider
adoption.
wide
variety
approaches
improve
measurement
performance
reduce
cost
are
explored;
these
include
interferometric
methods,
camera-based
multispeckle
detection,
long
path
photon
selection
improved
depth
sensitivity.
We
review
here
current
status
DCS
summarize
future
development
directions
challenges
that
on
widespread
Neurophotonics,
Journal Year:
2016,
Volume and Issue:
3(3), P. 031411 - 031411
Published: June 21, 2016
Cerebral
blood
flow
(CBF)
and
cerebral
autoregulation
(CA)
are
critically
important
to
maintain
proper
brain
perfusion
supply
the
with
necessary
oxygen
energy
substrates.
Adequate
is
required
support
normal
function,
achieve
successful
aging,
navigate
acute
chronic
medical
conditions.
We
review
general
principles
of
CBF
measurements
current
techniques
measure
based
on
direct
intravascular
measurements,
nuclear
medicine,
X-ray
imaging,
magnetic
resonance
ultrasound
techniques,
thermal
diffusion,
optical
methods.
also
for
arterial
pressure
as
well
theoretical
experimental
methods
assessment
CA,
including
recent
approaches
techniques.
The
in
clinical
practice
presented.
comprehensive
description
principles,
methods,
requirements
CA
highlights
potentially
role
that
noninvasive
can
play
neurovascular
health.
In
fact,
have
ability
provide
a
noninvasive,
quantitative,
continuous
monitor
autoregulation.
Journal of Applied Physiology,
Journal Year:
2019,
Volume and Issue:
126(5), P. 1360 - 1376
Published: March 7, 2019
Near
infrared
spectroscopy
(NIRS)
is
a
powerful
noninvasive
tool
with
which
to
study
the
matching
of
oxygen
delivery
utilization
and
number
new
publications
utilizing
this
technique
has
increased
exponentially
in
last
20
yr.
By
measuring
state
oxygenation
primary
heme
compounds
skeletal
muscle
(hemoglobin
myoglobin),
greater
understanding
underlying
control
mechanisms
that
couple
perfusive
diffusive
oxidative
metabolism
can
be
gained
from
laboratory
athletic
field
intensive
care
unit
or
emergency
room.
However,
NIRS
been
complicated
by
diversity
instrumentation,
inherent
limitations
some
these
technologies,
associated
terminology,
general
lack
standardization
protocols.
This
Cores
Reproducibility
Physiology
(CORP)
will
describe
basic
but
important
detail
most
common
methodologies
NIRS,
their
strengths
limitations,
discuss
potential
confounding
factors
affect
quality
reproducibility
data.
Recommendations
are
provided
reduce
variability
errors
data
collection,
analysis,
interpretation.
The
goal
CORP
provide
readers
methodology,
best
practices
so
as
improve
research
muscle.
Journal of Biomedical Optics,
Journal Year:
2016,
Volume and Issue:
21(9), P. 091313 - 091313
Published: July 21, 2016
In
most
daily
activities
related
to
work
or
leisure,
the
energy
for
muscle
substantially
comes
from
oxidative
metabolism.
Functional
limitations
impairments
of
this
metabolism
can
significantly
affect
exercise
tolerance
and
performance.
As
a
method
functional
evaluation
skeletal
metabolism,
near-infrared
spectroscopy
(NIRS)
has
important
strengths
but
also
several
limitations,
some
which
have
been
overcome
by
recent
technological
developments.
Skeletal
fractional
O2
extraction,
main
variable
be
noninvasively
evaluated
NIRS,
is
result
dynamic
balance
between
utilization
delivery;
it
yield
relevant
information
on
key
physiological
pathophysiological
mechanisms,
in
performance
healthy
subjects
(in
normal
altered
environmental
conditions)
patients.
right
hands,
NIRS
offer
insights
into
adaptations
conditions
increased
needs
that
involve,
an
integrated
manner,
different
organs
systems
body.
terms
patient
evaluation,
allows
determination
evolution
impairments,
identify
their
correlations
with
clinical
symptoms,
evaluate
effects
therapeutic
rehabilitative
interventions,
gain
diagnostic
insights.
Biomedical Optics Express,
Journal Year:
2014,
Volume and Issue:
5(11), P. 4053 - 4053
Published: Oct. 28, 2014
We
develop
and
validate
a
Modified
Beer-Lambert
law
for
blood
flow
based
on
diffuse
correlation
spectroscopy
(DCS)
measurements.The
new
formulation
enables
monitoring
from
temporal
intensity
autocorrelation
function
data
taken
at
single
or
multiple
delay-times.Consequentially,
the
speed
of
optical
measurement
can
be
substantially
increased.The
scheme
facilitates
highly
scattering
tissues
in
geometries
wherein
light
propagation
is
diffusive
non-diffusive,
it
particularly
well-suited
utilization
with
pressure
paradigms
that
employ
differential
signals
to
reduce
contributions
superficial
tissues.
Neurophotonics,
Journal Year:
2014,
Volume and Issue:
1(1), P. 011009 - 011009
Published: June 20, 2014
Diffuse
correlation
spectroscopy
(DCS)
is
an
emerging
optical
modality
used
to
measure
cortical
cerebral
blood
flow.
This
outlook
presents
a
brief
overview
of
the
technology,
summarizing
advantages
and
limitations
method,
describing
its
recent
applications
animal,
adult,
infant
cohorts.
At
last,
paper
highlights
future
where
DCS
may
play
pivotal
role
individualizing
patient
management
enhancing
our
understanding
neurovascular
coupling,
activation,
brain
development.
Neurophotonics,
Journal Year:
2022,
Volume and Issue:
9(S2)
Published: Aug. 30, 2022
This
report
is
the
second
part
of
a
comprehensive
two-part
series
aimed
at
reviewing
an
extensive
and
diverse
toolkit
novel
methods
to
explore
brain
health
function.
While
first
focused
on
neurophotonic
tools
mostly
applicable
animal
studies,
here,
we
highlight
optical
spectroscopy
imaging
relevant
noninvasive
human
studies.
We
outline
current
state-of-the-art
technologies
software
advances,
most
recent
impact
these
neuroscience
clinical
applications,
identify
areas
where
innovation
needed,
provide
outlook
for
future
directions.
