Behaviorally meaningful functional networks mediate the effect of Alzheimer’s pathology on cognition DOI
Jacob Ziontz, Theresa M. Harrison, Xi Chen

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(4)

Published: April 1, 2024

Abstract Tau pathology is associated with cognitive impairment in both aging and Alzheimer’s disease, but the functional structural bases of this relationship remain unclear. We hypothesized that integrity behaviorally meaningful networks would help explain between tau performance. Using resting state fMRI, we identified unique related to episodic memory executive function domains. The network was particularly measured positron emission tomography entorhinal temporal cortices. Further, strength mediated performance above beyond neurodegeneration. replicated association these a separate cohort older adults, including cognitively unimpaired mildly impaired individuals. Together, results suggest brain represent mechanism linking cognition.

Language: Английский

Connectome-based prediction of eating disorder-associated symptomatology DOI

Ximei Chen,

Debo Dong, Feng Zhou

et al.

Psychological Medicine, Journal Year: 2022, Volume and Issue: 53(12), P. 5786 - 5799

Published: Sept. 30, 2022

Despite increasing knowledge on the neuroimaging patterns of eating disorder (ED) symptoms in non-clinical populations, studies using whole-brain machine learning to identify connectome-based neuromarkers ED symptomatology are absent. This study examined association connectivity within and between large-scale functional networks with specific symptomatic behaviors cognitions predictive modeling (CPM).CPM ten-fold cross-validation was carried out probe that were ED-associated symptomatology, including body image concerns, binge eating, compensatory behaviors, discovery sample 660 participants. The ability identified validated an independent 821 participants.The concerns implicated cognitive control (frontoparietal medial frontal), reward sensitivity (subcortical), visual perception (visual). Crucially, set connections positive network related one generalized predict sample, suggesting replicability this effect.These findings point feasibility connectome general population provide first evidence interplay among distributed predicts shape/weight concerns.

Language: Английский

Citations

10
Functional connectivity dynamics as a function of the fluctuation of tension during film watching DOI

Yadi Sun,

Junji Ma,

Miner Huang

et al.

Brain Imaging and Behavior, Journal Year: 2022, Volume and Issue: 16(3), P. 1260 - 1274

Published: Jan. 6, 2022

Language: Английский

Citations

9
Connectome-based predictive models using resting-state fMRI for studying brain aging DOI
Eunji Kim, Seung‐Ho Kim,

Yunheung Kim

et al.

Experimental Brain Research, Journal Year: 2022, Volume and Issue: 240(9), P. 2389 - 2400

Published: Aug. 4, 2022

Language: Английский

Citations

9
Cognitive abilities are associated with specific conjunctions of structural and functional neural subnetworks DOI Creative Commons
Daniel Kristanto, Andrea Hildebrandt, Werner Sommer

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 279, P. 120304 - 120304

Published: Aug. 1, 2023

Cognitive neuroscience assumes that different mental abilities correspond to at least partly separable brain subnetworks and strives understand their relationships. However, single-task approaches typically revealed multiple be involved in performance. Here, we chose a bottom-up approach of investigating the association between structural functional subnetworks, on one hand, domain-specific cognitive abilities, other. Structural network was identified using machine-learning graph neural by clustering anatomical properties measured 838 individuals enroled WU-Minn Young Adult Human Connectome Project. Functional adapted from seven Resting State Networks (7-RSN). We then analyzed results 15 tasks estimated five latent abilities: fluid reasoning (Gf), crystallized intelligence (Gc), memory (Mem), executive functions (EF), processing speed (Gs). In final step determined linear associations these independently ability entities. found no one-to-one mapping subnetworks. Analyses are associated with particular combinations While some more strongly within-subnetwork connections, others related connections Importantly, commonly rely node(s) as hub(s) connect other To test robustness our findings, ran analyses through several defensible analytical decisions. Together, present findings allow novel perspective distinct nature building upon unique

Language: Английский

Citations

5
Behaviorally meaningful functional networks mediate the effect of Alzheimer’s pathology on cognition DOI
Jacob Ziontz, Theresa M. Harrison, Xi Chen

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(4)

Published: April 1, 2024

Abstract Tau pathology is associated with cognitive impairment in both aging and Alzheimer’s disease, but the functional structural bases of this relationship remain unclear. We hypothesized that integrity behaviorally meaningful networks would help explain between tau performance. Using resting state fMRI, we identified unique related to episodic memory executive function domains. The network was particularly measured positron emission tomography entorhinal temporal cortices. Further, strength mediated performance above beyond neurodegeneration. replicated association these a separate cohort older adults, including cognitively unimpaired mildly impaired individuals. Together, results suggest brain represent mechanism linking cognition.

Language: Английский

Citations

1