Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 131, P. 1076 - 1095

Published: Oct. 20, 2021

Language: Английский

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Multimodal Neural and Behavioral Data Predict Response to Rehabilitation in Chronic Poststroke Aphasia

Stroke, Journal Year: 2022, Volume and Issue: 53(5), P. 1606 - 1614

Published: Jan. 26, 2022

Poststroke recovery depends on multiple factors and varies greatly across individuals. Using machine learning models, this study investigated the independent complementary prognostic role of different patient-related in predicting response to language rehabilitation after a stroke.Fifty-five individuals with chronic poststroke aphasia underwent battery standardized assessments structural functional magnetic resonance imaging scans, received 12 weeks treatment. Support vector random forest models were constructed predict responsiveness treatment using pretreatment behavioral, demographic, neuroimaging data.The best prediction performance was achieved by support model trained severity, demographics, measures anatomic integrity resting-state connectivity (F1=0.94). This resulted significantly superior compared all feature sets (F1=0.82, P<0.001) or single set (F1 range=0.68-0.84, P<0.001). Across training data yielded F1 score (F1=0.87).While multimodal demographic information carry aphasia, brain at rest stroke is particularly important predictor treatment, both alone combined other factors.

Language: Английский

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Intraoperative cortical localization of music and language reveals signatures of structural complexity in posterior temporal cortex

iScience, Journal Year: 2023, Volume and Issue: 26(7), P. 107223 - 107223

Published: June 28, 2023

Language and music involve the productive combination of basic units into structures. It remains unclear whether brain regions sensitive to linguistic musical structure are co-localized. We report an intraoperative awake craniotomy in which a left-hemispheric language-dominant professional musician underwent cortical stimulation mapping (CSM) electrocorticography language perception production during repetition tasks. Musical sequences were melodic or amelodic, differed algorithmic compressibility (Lempel-Ziv complexity). Auditory recordings sentences syntactic complexity (single vs. multiple phrasal embeddings). CSM posterior superior temporal gyrus (pSTG) disrupted production, along with speech production. pSTG middle (pMTG) activated for (broadband gamma; 70-150 Hz). pMTG activity was modulated by complexity, while complexity. This points shared resources comprehension, but distinct neural signatures processing domain-specific structural features.

Language: Английский

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Inefficient speech-motor control affects predictive speech comprehension: atypical electrophysiological correlates in stuttering

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(11), P. 6834 - 6851

Published: Jan. 21, 2023

Abstract Listeners predict upcoming information during language comprehension. However, how this ability is implemented still largely unknown. Here, we tested the hypothesis proposing that production mechanisms have a role in prediction. We studied 2 electroencephalographic correlates of predictability speech comprehension—pre-target alpha–beta (8–30 Hz) power decrease and post-target N400 event-related potential effect—in population with impaired speech-motor control, i.e. adults who stutter (AWS), compared to typically fluent (TFA). Participants listened sentences could either constrain towards target word or not, modulating its predictability. As complementary task, participants also performed context-driven production. Compared TFA, AWS not only displayed atypical neural responses production, but, critically, they showed different pattern Specifically, while TFA expected pre-target decrease, increase frontal regions, associated control. In addition, effect was reduced for respect TFA. Finally, found comprehension changes were positively correlated but AWS. Overall, results support idea processes structures prominently devoted planning prediction

Language: Английский

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Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum

Brain, Journal Year: 2023, Volume and Issue: 147(2), P. 607 - 626

Published: Sept. 26, 2023

Abstract The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a neurodegenerative syndrome primarily defined by the presence apraxia speech (AoS) and/or expressive agrammatism. In addition, many patients exhibit dysarthria receptive This leads to substantial phenotypic variation within speech-language domain across individuals and time, in terms both specific combination symptoms as well their severity. How resolve such heterogeneity nfvPPA matter debate. ‘Splitting’ views propose separate clinical entities: ‘primary speech’ when AoS occurs absence agrammatism, ‘progressive agrammatic aphasia’ (PAA) opposite case, ‘AOS + PAA’ mixed motor language are clearly present. While therapeutic interventions typically vary depending on predominant symptom (e.g. versus agrammatism), existence behavioural, anatomical pathological overlap these phenotypes argues against drawing clear-cut boundaries. current study, we contribute this debate mapping behaviour brain large, prospective cohort characterized with (n = 104). We sought advance scientific understanding neural basis uncovering where degree MRI-based atrophy associated inter-patient variability severity AoS, dysarthria, agrammatism or Our cross-sectional examination brain-behaviour relationships revealed three main observations. First, found that correlates lie side left posterior inferior frontal lobe, explaining behavioural dissociation/association previous reports. Second, identified ‘left-right’ ‘ventral-dorsal’ neuroanatomical distinction between highlighting (i) but not significantly influenced tissue loss right-hemisphere motor-speech regions; (ii) that, hemisphere, map onto dorsally ventrally located regions, respectively. Third, confirmed large-scale grammar network, preferentially involved temporal findings thus define function location epicentres networks vulnerable changes nfvPPA. be redefined an umbrella term subsuming spectrum closely linked underlying neuroanatomy neuropathology.

Language: Английский

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Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases

Cortex, Journal Year: 2021, Volume and Issue: 142, P. 47 - 61

Published: June 2, 2021

Language: Английский

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Advanced Brain Age and Chronic Poststroke Aphasia Severity

Neurology, Journal Year: 2022, Volume and Issue: 100(11)

Published: Dec. 16, 2022

Chronic poststroke language impairment is typically worse in older individuals or those with large stroke lesions. However, there unexplained variance that likely depends on intact tissue beyond the lesion. Brain age an emerging concept, which partially independent from chronologic age. Advanced brain associated cognitive decline healthy adults; therefore, we aimed to investigate relationship aphasia. We hypothesized advanced a significant factor chronic impairments, above and age, lesion characteristics.This cohort study retrospectively evaluated participants Predicting Outcomes of Language Rehabilitation Aphasia clinical trial (NCT03416738), recruited through local advertisement South Carolina (US). Primary inclusion criteria were left hemisphere aphasia (≥12 months after stroke). Participants completed baseline behavioral testing including Western Battery-Revised (WAB-R), Philadelphia Naming Test (PNT), Pyramids Palm Trees (PPTT), Wechsler Adult Intelligence Scale Matrices subtest, before completing 6 weeks therapy. The PNT was repeated 1 month leveraged modern neuroimaging techniques estimate computed proportional difference between estimated Multiple linear regression models used evaluate (PBAD) behavior.Participants (N = 93, 58 males 35 females, average 61 years) had ages ranging 14 years younger 23 than predicted performance semantic tasks (PPTT) (WAB-R). For aging (n 47), treatment gains (improvement PNT) independently by PBAD (T -2.0474, p 0.0468, 9% explained).Through application techniques, severity tasks. Notably, therapy outcome scores also PBAD, albeit only among aging. These findings corroborate importance as determinant recovery underscore personalized health factors determining trajectories, should be considered during planning implementation therapeutic interventions.

Language: Английский

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Brain Areas Critical for Picture Naming: A Systematic Review and Meta-Analysis of Lesion-Symptom Mapping Studies

Neurobiology of Language, Journal Year: 2023, Volume and Issue: 4(2), P. 280 - 296

Published: Jan. 1, 2023

Lesion-symptom mapping (LSM) studies have revealed brain areas critical for naming, typically finding significant associations between damage to left temporal, inferior parietal, and fontal regions impoverished naming performance. However, specific subregions found in the available literature vary. Hence, aim of this study was perform a systematic review meta-analysis published lesion-based findings, obtained from with unique cohorts investigating accuracy stroke patients at least 1 month post-onset. An anatomic likelihood estimation (ALE) these LSM performed. Ten papers entered ALE meta-analysis, similar lesion coverage over temporal frontal areas. This small number is major limitation present study. Clusters were anterior lobe, posterior lobe extending into parietal areas, line arcuate fasciculus, pre- postcentral gyri middle gyrus. No clusters These results further substantiated by examining five that investigated performance beyond global accuracy, corroborating results. The highlight involvement cortices mid portions particular conceptual-lexical retrieval speaking.

Language: Английский

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Structural disconnections associated with language impairments in chronic post-stroke aphasia using disconnectome maps

Cortex, Journal Year: 2022, Volume and Issue: 155, P. 90 - 106

Published: July 19, 2022

Language: Английский

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Grammatical Parallelism in Aphasia: A Lesion-Symptom Mapping Study

Neurobiology of Language, Journal Year: 2023, Volume and Issue: 4(4), P. 550 - 574

Published: Jan. 1, 2023

Abstract Sentence structure, or syntax, is potentially a uniquely creative aspect of the human mind. Neuropsychological experiments in 1970s suggested parallel syntactic production and comprehension deficits agrammatic Broca’s aphasia, thought to result from damage mechanisms area left frontal lobe. This hypothesis was sometimes termed overarching agrammatism, converging with developments linguistic theory concerning central supporting language comprehension. However, evidence an association among receptive deficits, expressive cortex equivocal. In addition, relationship distinct grammatical deficit paragrammatism, syntax has not been assessed. We used lesion-symptom mapping three partially overlapping groups left-hemisphere stroke patients investigate these issues: primary group 53 subjects larger sample sizes (N = 130, 218) that overlapped group. Paragrammatic were significantly associated multiple analyses comprehension, particularly when incorporating lesion volume as covariate, but not. The correlates impaired performance temporal lobe regions, which also implicated inferior middle regions agrammatism. Our results provide strong against agrammatism hypothesis. By contrast, our suggest possibility alternative parallelism rooted paragrammatism system posterior

Language: Английский

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