Multi-scale asynchronous correlation and 2D convolutional autoencoder for adolescent health risk prediction with limited fMRI data DOI Creative Commons
Di Gao,

Guanghao Yang,

Jiarun Shen

et al.

Frontiers in Computational Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 15, 2024

Introduction Adolescence is a fundamental period of transformation, encompassing extensive physical, psychological, and behavioral changes. Effective health risk assessment during this stage crucial for timely intervention, yet traditional methodologies often fail to accurately predict mental risks due the intricacy neural dynamics scarcity quality-annotated fMRI datasets. Methods This study introduces an innovative deep learning-based framework in adolescents by employing combination two-dimensional convolutional autoencoder (2DCNN-AE) with multi-sequence learning multi-scale asynchronous correlation information extraction techniques. approach facilitates intricate analysis spatial temporal features within data, aiming enhance accuracy process. Results Upon examination using Adolescent Risk Behavior (AHRB) dataset, which includes scans from 174 individuals aged 17–22, proposed methodology exhibited significant improvement over conventional models. It attained precision 83.116%, recall 84.784%, F1-score 83.942%, surpassing standard benchmarks most pertinent evaluative measures. Discussion The results underscore superior performance understanding predicting health-related adolescents. underscores value advancing assessments, offering enhanced tool early detection potential intervention strategies sensitive developmental stage.

Language: Английский

Neuroticism/Negative Emotionality Is Associated with Increased Reactivity to Uncertain Threat in the Bed Nucleus of the Stria Terminalis, Not the Amygdala DOI
Shannon E. Grogans, Juyoen Hur, Matthew G. Barstead

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(32), P. e1868232024 - e1868232024

Published: July 15, 2024

Neuroticism/negative emotionality (N/NE)-the tendency to experience anxiety, fear, and other negative emotions-is a fundamental dimension of temperament with profound consequences for health, wealth, well-being. Elevated N/NE is associated panoply adverse outcomes, from reduced socioeconomic attainment psychiatric illness. Animal research suggests that reflects heightened reactivity uncertain threat in the bed nucleus stria terminalis (BST) central amygdala (Ce), but relevance these discoveries humans has remained unclear. Here we used novel combination psychometric, psychophysiological, neuroimaging approaches test this hypothesis an ethnoracially diverse, sex-balanced sample 220 emerging adults selectively recruited encompass broad spectrum N/NE. Cross-validated robust-regression analyses demonstrated preferentially BST activation during anticipation genuinely distressing (aversive multimodal stimulation), whereas was unrelated certain-threat anticipation, Ce either type or BST/Ce threat-related faces. It often assumed different paradigms are interchangeable assays individual differences brain function, yet rarely been tested. Our results revealed negligible associations between presentation faces, indicating two tasks nonfungible. These observations provide framework conceptualizing emotional traits disorders; guiding design interpretation biobank studies risk, disease, treatment; refining mechanistic research.

Language: Английский

Citations

2
Neural Responses to Social Reward Predict Depressive Symptoms in Adolescent Girls During the COVID-19 Pandemic DOI Creative Commons
Stefanie Sequeira, Jennifer S. Silk, Emily Hutchinson

et al.

Journal of Pediatric Psychology, Journal Year: 2021, Volume and Issue: 46(8), P. 915 - 926

Published: March 22, 2021

Abstract Objective Adolescent depression is increasing during the COVID-19 pandemic, possibly related to dramatic social changes. Individual-level factors that contribute functioning, such as temperament and neural reactivity feedback, may confer risk for or resilience against depressive symptoms pandemic. Methods Ninety-three girls (12–17 years) oversampled high shy/fearful were recruited from a longitudinal study follow-up study. During parent (2016–2018), participants completed functional magnetic resonance imaging task eliciting activity performance-related feedback. Depressive assessed (April–May 2020). In 65 with complete data, we examined how interactions between activation reward punishment in socio-affective brain network predict COVID-19. Results increased Significant caudate, putamen, insula found. Girls showed negative associations symptoms, whereas lower positive associations. Conclusions reduced be less likely engage socially, which could detrimental pandemic when are limited. contrast, heightened highly motivated also limited opportunities. both cases, improving connection attenuate prevent symptoms.

Language: Английский

Citations

13
Editorial: Toward Neurobiological-Based Treatments of Depression and Anxiety: A Potential Case for the Nucleus Accumbens DOI Creative Commons
Tiffany C. Ho

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2021, Volume and Issue: 61(2), P. 136 - 138

Published: June 30, 2021

Language: Английский

Citations

10
Splitting the reward: Differences in inflammatory marker associations with neural connectivity between reward anticipation and reward outcome in adolescents at high risk for depression DOI Creative Commons
Manivel Rengasamy, Melissa Nance, Kristen Eckstrand

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 327, P. 128 - 136

Published: Feb. 3, 2023

Language: Английский

Citations

4
Sex-Specific Vulnerability to Externalizing Problems: Sensitivity to Early Stress and Nucleus Accumbens Activation Over Adolescence DOI
Lauren R. Borchers, Justin P. Yuan, Josiah K. Leong

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1
Impact of analytic decisions on test-retest reliability of individual and group estimates in functional magnetic resonance imaging: a multiverse analysis using the monetary incentive delay task DOI Creative Commons
Michael I. Demidenko, Jeanette A. Mumford, Russell A. Poldrack

et al.

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 26

Published: Jan. 1, 2024

Abstract Empirical studies reporting low test–retest reliability of individual blood oxygen-level dependent (BOLD) signal estimates in functional magnetic resonance imaging (fMRI) data have resurrected interest among cognitive neuroscientists methods that may improve fMRI. Over the last decade, several reported modeling decisions, such as smoothing, motion correction, and contrast selection, BOLD estimates. However, it remains an empirical question whether certain analytic decisions consistently individual- group-level fMRI task across multiple large, independent samples. This study used three samples (Ns: 60, 81, 119) collected same (Monetary Incentive Delay task) two runs sessions to evaluate effects on (intraclass correlation coefficient [ICC(3,1)]) group (Jaccard/Spearman rho) activity data. The this vary four categories: smoothing kernel (five options), correction (four parameterizing (three contrasts totaling 240 different pipeline permutations. Across all pipelines, median ICC are low, with a maximum estimate .43 – .55 3 greatest impact similarity Implicit Baseline contrast, Cue Model parameterization, larger kernel. Using condition meaningfully increased compared using Neutral cue. effect was largest for parameterization; however, improvements came at cost interpretability. illustrates MID variable small samples, higher not always interpretability estimated signal.

Language: Английский

Citations

1
Reliability and Stability Challenges in ABCD Task fMRI Data DOI Open Access

James T. Kennedy,

Michael P. Harms,

Ozlem Korucuoglu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: Oct. 9, 2021

Abstract Trait stability of measures is an essential requirement for individual differences research. Functional MRI has been increasingly used in studies that rely on the assumption trait stability, such as attempts to relate task related brain activation behavior and psychopathology. However, recent research using adult samples questioned task-fMRI measures, assessed by test-retest correlations. To date, little known about fMRI children. Here, we examined within-session reliability longitudinal data from Adolescent Brain Cognitive Development (ABCD) Study its tasks focused reward processing, response inhibition, working memory. We also evaluated effects factors potentially affecting stability. Reliability [quantified via intraclass correlation (ICC) focuses rank consistency] was poor virtually all regions, with average ICC .078 .054 short (within-session) long-term (between-session) ICCs, respectively, regions interest (ROIs) historically-recruited tasks. values ROIs did not exceed ‘poor’ cut-off .4, fact rarely exceeded .2 (only 5.9%). Motion had a pronounced effect estimated lowest motion quartile participants having mean reliability/stability three times higher (albeit still ‘poor’) than highest quartile. Regions stronger tended show absolute value activity correlating at .53. Across magnitude age-related changes positively correlated differences, which suggests developmental change necessarily responsible Poor task-fMRI, particularly children, diminishes potential utility due drastic reduction sizes and, consequently, statistical power detection brain-behavior associations. This issue needs be addressed through optimization preprocessing pipelines denoising methods.

Language: Английский

Citations

9
A brief child-friendly reward task reliably activates the ventral striatum in two samples of socioeconomically diverse youth DOI Creative Commons
Melissa K. Peckins, Heidi B. Westerman, S. Alexandra Burt

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(2), P. e0263368 - e0263368

Published: Feb. 3, 2022

Adolescence is a period of increased risk-taking behavior, thought to be driven, in part, by heightened reward sensitivity. One challenge studying processing the field developmental neuroscience finding task that activates circuitry, and short, not too complex, engaging for youth wide variety ages socioeconomic backgrounds. In present study, we tested brief child-friendly activating circuitry two independent samples 7-19 years old enriched poverty (study 1: n = 464; study 2: 27). The robustly activated ventral striatum, with activation decreasing from early mid-adolescence increasing mid- late adolescence response reward. This did vary gender, pubertal development, or income-to-needs ratio, making applicable populations. Additionally, striatum differ between who expect receive prize at end task, indicating an outcome points alone may enough engage circuitry. Thus, this effective different

Language: Английский

Citations

5
Adolescent to young adult longitudinal development across 8 years for matching emotional stimuli during functional magnetic resonance imaging DOI Creative Commons
Nora C. Vetter, Juliane H. Fröhner,

Klara Hoffmann

et al.

Developmental Cognitive Neuroscience, Journal Year: 2022, Volume and Issue: 57, P. 101131 - 101131

Published: July 3, 2022

We investigated development from adolescence to young adulthood of neural bottom-up and top-down processes using a functional magnetic resonance imaging task on emotional attention. followed 249 participants age 14-22 in up four waves resulting 687 total scans matching which decided whether two pictures were the same including distracting or neutral scenes. applied generalized additive mixed models reliability approach for longitudinal analysis. Reaction times error rates decreased longitudinally. For processing, we found increase bilateral inferior frontal gyrus (IFG) negative stimuli left IFG also positive stimuli. activation amygdala, relative stability stimuli, there was an starting twenties. Results show ongoing behavioral prefrontal relatively independent valence. Amygdala remained stable except Current findings add sparse literature into emphasize role reliability. These might help characterize healthy contrast dysfunctional

Language: Английский

Citations

4
Neuroticism/negative emotionality is associated with increased reactivity to uncertain threat in the bed nucleus of the stria terminalis, not the amygdala DOI Creative Commons
Shannon E. Grogans, Juyoen Hur, Matthew G. Barstead

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 10, 2023

Neuroticism/Negative Emotionality (N/NE)-the tendency to experience anxiety, fear, and other negative emotions-is a fundamental dimension of temperament with profound consequences for health, wealth, wellbeing. Elevated N/NE is associated panoply adverse outcomes, from reduced socioeconomic attainment psychiatric illness. Animal research suggests that reflects heightened reactivity uncertain threat in the bed nucleus stria terminalis (BST) central amygdala (Ce), but relevance these discoveries humans has remained unclear. Here we used novel combination psychometric, psychophysiological, neuroimaging approaches rigorously test this hypothesis an ethnoracially diverse, sex-balanced sample 220 emerging adults selectively recruited encompass broad spectrum N/NE. Cross-validated robust-regression analyses demonstrated preferentially BST activation during anticipation genuinely distressing (aversive multimodal stimulation), whereas was unrelated certain-threat anticipation, Ce either type or BST/Ce threat-related faces. It often assumed different paradigms are interchangeable assays individual differences brain function, yet rarely been tested. Our results revealed negligible associations between presentation faces, indicating two tasks non-fungible. These observations provide framework conceptualizing emotional traits disorders; guiding design interpretation biobank studies risk, disease, treatment; informing mechanistic research.

Language: Английский

Citations

2