Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans

Nature Human Behaviour, Journal Year: 2022, Volume and Issue: 6(12), P. 1705 - 1722

Published: Sept. 22, 2022

Language: Английский

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Integrating brainstem and cortical functional architectures

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The brainstem is a fundamental component of the central nervous system, yet it typically excluded from in vivo human brain mapping efforts, precluding complete understanding how influences cortical function. In this study, we used high-resolution 7-Tesla functional magnetic resonance imaging to derive connectome encompassing cortex and 58 nuclei spanning midbrain, pons medulla. We identified compact set integrative hubs with widespread connectivity cerebral cortex. Patterns between manifest as neurophysiological oscillatory rhythms, patterns cognitive specialization unimodal–transmodal hierarchy. This persistent alignment topographies shaped by spatial arrangement multiple neurotransmitter receptors transporters. replicated all findings using 3-Tesla data same participants. Collectively, work demonstrates that organizational features activity can be traced back brainstem.

Language: Английский

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Spinal Cord fMRI: A New Window into the Central Nervous System

The Neuroscientist, Journal Year: 2022, Volume and Issue: 29(6), P. 715 - 731

Published: July 13, 2022

With the brain, spinal cord forms central nervous system. Initially considered a passive relay between brain and periphery, is now recognized as being active plastic. Yet, it remains largely overlooked by human neuroscience community, in stark contrast with wealth of research investigating brain. In this review, we argue that fMRI, traditionally used to image cerebral function, can be extended beyond help unravel mechanisms involved behaviors. To end, first outline strategies have been proposed tackle challenges inherent fMRI. Then, discuss how they utilized provide insights into functional organization sensorimotor circuits, highlighting their potential address fundamental clinical questions. By summarizing guidelines applications hope stimulate support further promising yet underexplored field.

Language: Английский

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Spinal fMRI demonstrates segmental organisation of functionally connected networks in the cervical spinal cord: A test–retest reliability study

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(2)

Published: Jan. 31, 2024

Abstract Resting functional magnetic resonance imaging (fMRI) studies have identified intrinsic spinal cord activity, which forms organised motor (ventral) and sensory (dorsal) resting‐state networks. However, to facilitate the use of fMRI in, for example, clinical studies, it is crucial first assess reliability method, particularly given unique anatomical, physiological, methodological challenges associated with acquiring data. Here, we characterise connectivity relationships in cervical their between‐session test–retest 23 young healthy volunteers. Resting‐state networks were estimated two ways (1) by estimating seed‐to‐voxel maps (2) calculating seed‐to‐seed correlations. Seed regions corresponded four grey matter horns (ventral/dorsal left/right) C5–C8 segmental levels. Test–retest was assessed using intraclass correlation coefficient. Spatial overlap clusters derived from analysis between sessions examined Dice coefficients. Following analysis, observed distinct unilateral dorsal ventral organisation that largely confined rostro–caudal extent each level, more sparse connections segments. Additionally, strongest correlations within‐segment ipsilateral dorsal–ventral connections, followed dorso–dorsal ventro–ventral connections. these mixed. Reliability poor when on a voxelwise promising indications examining average signal within clusters. strength seeds highly variable, highest achieved dorso‐dorsal/ventro–ventral connectivity. spatial excellent. We demonstrate while mixed, similar across sessions, suggesting are characterised consistent representation over time.

Language: Английский

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Functional connectome of human cerebellum

NeuroImage, Journal Year: 2022, Volume and Issue: 251, P. 119015 - 119015

Published: Feb. 19, 2022

Background Neural connectome theory has been widely used in system neuroscience, and prompted our comprehension for the topological organizations of human cerebral cortex. However, how functional is organized topologically cerebellums remains unclear. Method Resting-state connectivity (rs-fcMRI) data were acquired from 1416 healthy adults two independent samples. In Sample 1 (n = 976), both voxel-wise node-wise properties cerebellar estimated. Moreover, network-based cerebellum cerebro-cerebellar mapping investigated, respectively. Given temporal natures neural population, a hidden Markov model (HMM) was further capitalized to uncover dynamic pattern connectome. order test robustness findings, we ran all analyses an dataset (Sample 2; n 440). Results We found that Crus I II exhibited prominently high degree centrality (DC) Further, even nested network-wise be by small-world, modular hierarchical manners significantly. Also, three intrinsic modules connectome, including attention/executive network, default mode network task-positive network. addition, significant correlations small-world organization architecture as well. By building mapping, frontoparietal subcortical networks overrepresented into than cortex (3-fold). As natures, observed highly flexible modular, but showed individual-specific variances pattern. Conclusion This study identified architectures hierarchy demonstrated prominent couplings architectures.

Language: Английский

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Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(11), P. 4602 - 4612

Published: April 19, 2023

Language: Английский

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Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 18, 2024

Abstract The hypothalamus is part of the hypothalamic-pituitary-adrenal axis which activates stress responses through release cortisol. It a small but heterogeneous structure comprising multiple nuclei. In vivo human neuroimaging has rarely succeeded in recording signals from individual Here we use resting-state fMRI (n = 498) with high spatial resolution to examine relationships between functional connectivity specific hypothalamic nuclei and dimensional marker prolonged stress. First, demonstrate that can parcellate into seven vivo. Using these other subcortical structures including amygdala, significantly predict scores out-of-sample. Predictions 0.0015% all possible brain edges, are stress, improve when using nucleus-specific compared whole-hypothalamus connectivity. Thus, relates changes precise functionally meaningful networks, may be exploited future studies interventions disorders.

Language: Английский

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Circuit-Based Approaches to Understanding Corticostriatothalamic Dysfunction Across the Psychosis Continuum

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(2), P. 113 - 124

Published: Aug. 8, 2022

Dopamine is known to play a role in the pathogenesis of psychotic symptoms, but mechanisms driving dopaminergic dysfunction psychosis remain unclear. Considerable attention has focused on corticostriatothalamic (CST) circuits, given that they regulate and are modulated by activity cells midbrain. Preclinical studies have proposed multiple models CST psychosis, each prioritizing different brain regions pathophysiological mechanisms. A particular challenge circuits undergone considerable evolutionary modification across mammals, complicating comparisons species. Here, we consider preclinical evaluate degree which supported evidence from human resting-state functional magnetic resonance imaging conducted continuum, ranging subclinical schizotypy established schizophrenia. In partial support some models, indicate dorsal hippocampal-striatal dysconnectivity apparent spectrum may represent vulnerability marker for psychosis. contrast, midbrain emerge when symptoms warrant clinical assistance thus be trigger illness onset. The major difference between findings strong involvement former, consistent with an increasing prominence this circuitry primate brain. We close underscoring need high-resolution characterization phenotypic heterogeneity develop refined understanding how specific circuit elements gives rise distinct symptom profiles.

Language: Английский

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Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources

NeuroImage, Journal Year: 2023, Volume and Issue: 275, P. 120152 - 120152

Published: May 2, 2023

The investigation of spontaneous fluctuations the blood-oxygen-level-dependent (BOLD) signal has recently been extended from brain to spinal cord, where it stimulated interest a clinical perspective. A number resting-state functional magnetic resonance imaging (fMRI) studies have demonstrated robust connectivity between time series BOLD in bilateral dorsal horns and those ventral horns, line with neuroanatomy cord. necessary step prior extension is assessing reliability such signals, which we aimed do here group 45 healthy young adults at clinically prevalent field strength 3T. When investigating entire cervical observed fair good for dorsal-dorsal ventral-ventral connectivity, whereas was poor within- between-hemicord dorsal-ventral connectivity. Considering how prone cord fMRI noise, extensively investigated impact distinct noise sources made two crucial observations: removal physiological led reduction - due stable participant-specific patterns thermal considerably increased detectability without clear influence on reliability. Finally, also assessed within segments that while pattern similar whole level single consistently poor. Taken together, our results demonstrate presence reliable human even after thoroughly accounting but same urge caution if focal changes (e.g. segmental lesions) are be studied, especially longitudinal manner.

Language: Английский

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The Cerebellar Connectome

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115457 - 115457

Published: Jan. 1, 2025

Language: Английский

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