The human language effective connectome

NeuroImage, Journal Year: 2022, Volume and Issue: 258, P. 119352 - 119352

Published: June 2, 2022

To advance understanding of brain networks involved in language, the effective connectivity between 26 cortical regions implicated language by a community analysis and 360 was measured 171 humans from Human Connectome Project, complemented with functional diffusion tractography, all using HCP multimodal parcellation atlas. A (semantic) network (Group 1) involving inferior superior temporal sulcus cortex (STS) adjacent visual TE1a pole TG, connected parietal PGi region, has (TE) regions; PFm which also connectivity; posterior cingulate memory-related frontal pole, orbitofrontal cortex, medial prefrontal cortex; dorsolateral 44 45 for output regions. It is proposed that this system can build its lobe (STS TG) parts (PGi PGs) semantic representations objects incorporating especially their reward properties. Another 3) more including STGa, auditory A5, TPOJ1, STV Peri-Sylvian Language area (PSL) areas (A1, A4, Pbelt); relatively early motion, e.g., MT MST, faces/words (FFC); somatosensory (frontal opercular FOP, insula PF); other TPOJ gyrus (IFJa IFSp). builds specialising related facial motion information useful theory mind / body image information, outputs directed not only to 45, but premotor 55b midcingulate cortex. Both (Groups 1 have access hippocampal episodic memory via parahippocampal TF. third largely 2) (44, 47l; 55b; Superior Frontal region SFL; TGv) receives two systems, syntax speech output.

Language: Английский

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The domain-separation language network dynamics in resting state support its flexible functional segregation and integration during language and speech processing

NeuroImage, Journal Year: 2023, Volume and Issue: 274, P. 120132 - 120132

Published: April 25, 2023

Modern linguistic theories and network science propose that language speech processing are organized into hierarchical, segregated large-scale subnetworks, with a core of dorsal (phonological) stream ventral (semantic) stream. The two streams asymmetrically recruited in receptive expressive or tasks, which showed flexible functional segregation integration. We hypothesized the was supported by underlying segregation. A dynamic conditional correlation approach employed to construct framewise time-varying networks k-means clustering investigate temporal-reoccurring patterns. found dynamics resting state were robustly clustered four states, dynamically reconfigured following domain-separation manner. Spatially, hub distributions first three states highly resembled neurobiology perception lexical-phonological processing, production, semantic respectively. fourth characterized weakest connectivity regarded as baseline state. Temporally, appeared exclusively limited time bins (∼15%), most (> 55%), 4 dominant. Machine learning-based dFC-linguistics prediction analyses dFCs significantly predicted individual performance. These findings suggest manner state, forms "meta-network" framework support integration during processing.

Language: Английский

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Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax

Journal of Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 36(6), P. 1141 - 1155

Published: Jan. 1, 2024

Abstract Disagreements persist regarding the neural basis of syntactic processing, which has been linked both to inferior frontal and posterior temporal regions brain. One focal point debate concerns role areas in receptive ability, is mostly assessed using sentence comprehension involving complex structures, a task that potentially confounded with working memory. Syntactic acceptability judgments may provide better measure syntax by reducing need use high memory load sentences enabling assessment various types violations. We therefore tested perception grammatical violations people poststroke aphasia (n = 25), along matched controls 16), English errors word order, agreement, or subcategorization. Lesion data were also collected. Control participants performed near ceiling accuracy higher discriminability agreement subcategorization than order; less able discriminate violations, but, on average, paralleled control Lesion-symptom mapping showed correlation between regions, but not regions. argue these results diverge from models holding are amodal core structure building favor posit hierarchical system

Language: Английский

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ROSE: A neurocomputational architecture for syntax

Journal of Neurolinguistics, Journal Year: 2023, Volume and Issue: 70, P. 101180 - 101180

Published: Nov. 21, 2023

Language: Английский

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Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum

Brain, Journal Year: 2023, Volume and Issue: 147(2), P. 607 - 626

Published: Sept. 26, 2023

Abstract The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) is a neurodegenerative syndrome primarily defined by the presence apraxia speech (AoS) and/or expressive agrammatism. In addition, many patients exhibit dysarthria receptive This leads to substantial phenotypic variation within speech-language domain across individuals and time, in terms both specific combination symptoms as well their severity. How resolve such heterogeneity nfvPPA matter debate. ‘Splitting’ views propose separate clinical entities: ‘primary speech’ when AoS occurs absence agrammatism, ‘progressive agrammatic aphasia’ (PAA) opposite case, ‘AOS + PAA’ mixed motor language are clearly present. While therapeutic interventions typically vary depending on predominant symptom (e.g. versus agrammatism), existence behavioural, anatomical pathological overlap these phenotypes argues against drawing clear-cut boundaries. current study, we contribute this debate mapping behaviour brain large, prospective cohort characterized with (n = 104). We sought advance scientific understanding neural basis uncovering where degree MRI-based atrophy associated inter-patient variability severity AoS, dysarthria, agrammatism or Our cross-sectional examination brain-behaviour relationships revealed three main observations. First, found that correlates lie side left posterior inferior frontal lobe, explaining behavioural dissociation/association previous reports. Second, identified ‘left-right’ ‘ventral-dorsal’ neuroanatomical distinction between highlighting (i) but not significantly influenced tissue loss right-hemisphere motor-speech regions; (ii) that, hemisphere, map onto dorsally ventrally located regions, respectively. Third, confirmed large-scale grammar network, preferentially involved temporal findings thus define function location epicentres networks vulnerable changes nfvPPA. be redefined an umbrella term subsuming spectrum closely linked underlying neuroanatomy neuropathology.

Language: Английский

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Conversational production and comprehension: fMRI-evidence reminiscent of but deviant from the classical Broca–Wernicke model

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(3)

Published: March 1, 2024

A key question in research on the neurobiology of language is to which extent production and comprehension systems share neural infrastructure, but this has not been addressed context conversation. We utilized a public fMRI dataset where 24 participants engaged unscripted conversations with confederate outside scanner, via an audio-video link. provide evidence indicating that two infrastructure left-lateralized perisylvian network, diverge regarding level activation regions within network. Activity left inferior frontal gyrus was stronger compared comprehension, while showed recruitment anterior middle temporal superior sulcus, production. Although our results are reminiscent classical Broca-Wernicke model, (rather than posterior) notable difference from model. This one findings may be consequence conversational setting, another being activated what we interpret as higher-level socio-pragmatic processes. In conclusion, present for partial overlap functional asymmetry above-mentioned vs during

Language: Английский

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The neurobiology of sentence production: A narrative review and meta-analysis

Brain and Language, Journal Year: 2025, Volume and Issue: 264, P. 105549 - 105549

Published: Feb. 20, 2025

Although there is a sizeable body of literature on sentence comprehension and processing both in healthy disordered language users, the production remains much more sparse. Linguistic computational descriptions expressive syntactic deficits aphasia are especially rare. In addition, neuroimaging (psycho) linguistic literatures operate largely separately. this paper, I will first lay out theoretical land with regard to psycholinguistic models production. then provide brief narrative overview large-scale meta-analysis as it pertains computation, followed by an attempt integrate findings from functional clinical neuroimaging. Finally, surrounding propose path forward close some existing gaps.

Language: Английский

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Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia

Brain Communications, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 1, 2025

Abstract Functional neuroimaging studies in neurotypical subjects correlate sentence comprehension to a left fronto-temporo-parietal network. Recent voxel-based lesion-symptom mapping (VLSM) of aphasia confirm the link between and posterior region including angular gyrus, supra-marginal gyrus postero-superior division temporal lobe but support pre-frontal involvement inconsistently. However, these focus on thematic role assignment without considering morphosyntactic processes. Hence, available VLSM evidence could provide partial view neurofunctional substrate comprehension. In present study, both processes were evaluated systematically same types each participant, more detailed picture Participants (33 patients with post-stroke 90 healthy controls) completed sentence–picture matching task which active passive, declarative reversible sentences paired morphosyntactic, lexical-semantic alternatives. Phonological short-term memory tasks also administered. Aphasic participants selected from an initial pool 70 because they scored below norm foils (n = 18) or morphological 15), within foils. The correlates starkly distinguishable. Pre-frontal areas inferior middle frontal involved directly processing local features only indirectly When damaged, errors always co-occurred errors, probably damage disrupts grammatical roles ultimately that roles. Morphosyntactic not influenced by word order canonicity. contrast, selective reversals linked parietal significantly order, occurring passive than sentences. An area was critical for non-canonical order. comprehension, regions are (at least simple sentences). Temporal Postero-superior retrieving verb argument structure. Parietal assigning morphosyntactically analysed constituents appropriate role, thus serving crucial function re-analysis. Each plays prevailing exclusive processes, interacting other network possibly providing language-specific domain-general resources needed at various stages

Language: Английский

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Grammatical Parallelism in Aphasia: A Lesion-Symptom Mapping Study

Neurobiology of Language, Journal Year: 2023, Volume and Issue: 4(4), P. 550 - 574

Published: Jan. 1, 2023

Abstract Sentence structure, or syntax, is potentially a uniquely creative aspect of the human mind. Neuropsychological experiments in 1970s suggested parallel syntactic production and comprehension deficits agrammatic Broca’s aphasia, thought to result from damage mechanisms area left frontal lobe. This hypothesis was sometimes termed overarching agrammatism, converging with developments linguistic theory concerning central supporting language comprehension. However, evidence an association among receptive deficits, expressive cortex equivocal. In addition, relationship distinct grammatical deficit paragrammatism, syntax has not been assessed. We used lesion-symptom mapping three partially overlapping groups left-hemisphere stroke patients investigate these issues: primary group 53 subjects larger sample sizes (N = 130, 218) that overlapped group. Paragrammatic were significantly associated multiple analyses comprehension, particularly when incorporating lesion volume as covariate, but not. The correlates impaired performance temporal lobe regions, which also implicated inferior middle regions agrammatism. Our results provide strong against agrammatism hypothesis. By contrast, our suggest possibility alternative parallelism rooted paragrammatism system posterior

Language: Английский

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Causal evidence for a coordinated temporal interplay within the language network

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(47)

Published: Nov. 14, 2023

Recent neurobiological models on language suggest that auditory sentence comprehension is supported by a coordinated temporal interplay within left-dominant brain network, including the posterior inferior frontal gyrus (pIFG), superior and sulcus (pSTG/STS), angular (AG). Here, we probed timing causal relevance of between these regions means concurrent transcranial magnetic stimulation electroencephalography (TMS-EEG). Our TMS-EEG experiments reveal region- time-specific evidence for bidirectional information flow from left pSTG/STS to pIFG back during processing. Adapting condition-and-perturb approach, our findings further can be AG in state-dependent manner.

Language: Английский

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