Quantitative susceptibility mapping of brain iron in healthy aging and cognition

NeuroImage, Journal Year: 2023, Volume and Issue: 282, P. 120401 - 120401

Published: Oct. 5, 2023

Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique that can assess the properties of cerebral iron in vivo. Although brain necessary for basic neurobiological functions, excess content disrupts homeostasis, leads to oxidative stress, and ultimately contributes neurodegenerative disease. However, some degree elevated present even among healthy older adults. To better understand topographical pattern accumulation its relation cognitive aging, we conducted systematic review 47 QSM studies with focus on five distinct themes. The first two themes focused age-related increases deep gray matter nuclei versus cortex. overall level higher than cortical regions. Deep vary regard effects, which are most prominent putamen, deposition also observed frontal, temporal, parietal regions during aging. third theme behavioral relevance indicated both was related decline fluid (speed-dependent) cognition. A handful multimodal studies, reviewed fourth theme, suggest interacts measures function, white degradation, neuropathologies. final concerning modifiers pointed potential roles cardiovascular, dietary, genetic factors. relatively recent tool assessing accumulation, it has significant promise contributing new insights into neurocognitive

Language: Английский

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The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4269 - 4269

Published: April 12, 2024

Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its involvement spans across main proteinopathies involving tau, amyloid-beta, alpha-synuclein, and TDP-43. Accumulating evidence supports contribution iron disease pathologies, but delineation its pathogenic role yet challenged by complex multiple neurotoxicity mechanisms supporting reciprocal influence between protein pathology. Here, we review major proteinopathy-specific observations four distinct hypotheses: (1) deposition consequence pathology; (2) promotes (3) protects from or hinders (4) pathology contribute parallelly to pathogenesis. an essential element for physiological function, requiring fine balance levels. Understanding disease-related at more intricate systemic level critical advancements chelation therapies.

Language: Английский

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Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 26, 2024

Introduction Alzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. This meta-analysis evaluated the use quantitative susceptibility mapping (QSM) to detect accumulation in deep gray matter (DGM) basal ganglia AD, contributing a better understanding AD progression, potentially leading new diagnostic therapeutic approaches. Methods Using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, Web Sciences, Google Scholar databases up October 2023 studies employing QSM research. Eligibility criteria were based on PECO framework, included assessing alterations magnetic indicative DGM patients with AD. After initial screening quality assessment using Newcastle-Ottawa Scale, was conducted compare levels between healthy controls (HCs) random-effects model. Results The nine comprising 267 272 HCs. There significantly higher values, indicating greater deposition, putamen (standardized mean difference (SMD) = 1.23; 95% CI: 0.62 1.84; p 0.00), globus pallidus (SMD 0.79; 0.07 1.52; 0.03), caudate nucleus 0.72; 0.39 1.06; 0.00) compared However, no significant differences found thalamus 1.00; −0.42 2.43; 0.17). sensitivity analysis indicated that single study impacted overall results. Age identified major contributor heterogeneity across all nuclei subgroup analysis. Older age (>69 years) lower male percentage (≤30%) associated increase Conclusion suggests excessive deposition is linked especially putamen. underscores complex nature pathology iron, influenced age, sex, regional differences, necessitating further research comprehensive understanding.

Language: Английский

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Evaluating the Potential of Quantitative Susceptibility Mapping for Detecting Iron Deposition of Renal Fibrosis in a Rabbit Model

Journal of Magnetic Resonance Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Background As ferroptosis is a key factor in renal fibrosis (RF), iron deposition monitoring may help evaluating RF. The capability of quantitative susceptibility mapping (QSM) for detecting RF remains uncertain. Purpose To investigate the potential QSM to detect Study Type Animal model. Model Eighty New Zealand rabbits were randomly divided into control (N = 10) and 70) groups, consisting baseline, 7, 14, 21, 28 days 12 each), longitudinal subgroups. was induced via unilateral arteria stenosis. Field Strength/Sequence 3 T, with gradient echo, arterial spin labeling echo. Assessment Bilateral kidney values ( χ ) cortex CO outer medulla OM evaluated histopathology. Statistical Tests Analysis variance, Kruskal–Wallis, Spearman's correlation, area under receiver operating characteristic curve (AUC). P < 0.05 significant. Results In fibrotic kidneys, decreased at 7 ([−6.69 ± 0.98] × 10 −2 ppm) increased during 14–28 ([−1.85 2.11], [0.14 0.58], [1.99 0.60] ppm, respectively), while had opposite trend. Both significantly correlated histopathology (| r | 0.674–0.849). AUC distinguishing degrees 0.692–0.993. contralateral initially ([−6.67 0.84] then recovered baseline ([−4.81 0.89] ppm), 7–28 ([2.58 1.40], [2.25 1.83], [2.49 [2.43 1.32] respectively) higher than ([0.54 0.18] ppm). Data Conclusion Different patterns observed values, suggesting Plain Language Summary Renal (RF) common outcome most diseases, leading scarring loss function. Increasing evidence suggests that abnormal metabolism plays an important role This study used technique called measure levels Specifically, advanced exhibited concentrations, moderate strong correlations between demonstrated could accurately changes assess severity. Overall, shows promise as tool progression. Evidence Level 2 Technical Efficacy Stage

Language: Английский

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Associations of quantitative susceptibility mapping with cortical atrophy and brain connectome in Alzheimer's disease: A multi-parametric study

NeuroImage, Journal Year: 2024, Volume and Issue: 290, P. 120555 - 120555

Published: March 5, 2024

Aberrant susceptibility due to iron level abnormality and brain network disconnections are observed in Alzheimer's disease (AD), with disrupted homeostasis hypothesized be linked AD pathology neuronal loss. However, whether associations exist between abnormal quantitative mapping (QSM), atrophy, altered connectome remains unclear. Based on multi-parametric imaging data from 30 patients 26 healthy controls enrolled at the China-Japan Friendship Hospital, we investigated of QSM signal volumetric measure across 246 regions patients. The structural functional connectomes were constructed based diffusion MRI tractography connectivity, respectively. topology was quantified using graph theory analyses. We revealed seven both reduced cortical thickness (p<0.05) AD, including right superior frontal gyrus, left temporal fusiform parietal lobule, inferior precuneus. Correlations computed subjects specific group resulted statistically significant correlations five these regions, higher compared topology. correlation topological metrics, value individual group-averaged levels, resulting a call spatial correlations. Decreased global efficiency also found level. These findings may provide insights into complex relationships among QSM, AD.

Language: Английский

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PET brain imaging in neurological disorders

Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 49, P. 100 - 111

Published: March 24, 2024

Language: Английский

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Iron Dysregulation in Alzheimer’s Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 295 - 295

Published: March 1, 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and neuropathological hallmarks, including β-amyloid (Aβ) plaques, Tau tangles, synaptic dysfunction neurodegeneration. Emerging evidence suggests that abnormal iron (Fe) metabolism plays role in AD pathogenesis, but the precise spatial distribution of Fe its transporters, such as ferroportin (FPN), within affected brain regions remains poorly understood. This study investigates FPN CA1 region human hippocampus patients with micrometer lateral resolution using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). For this purpose, we visualized quantified three separated layers: stratum molecular–radial (SMR), pyramidal (SP) oriens (SO). Additionally, chromogenic immunohistochemistry was used to examine colocalization Aβ proteins. The results show accumulation significantly higher brains, particularly SMR SO. However, did not present changes AD, although it showed non-uniform across layers, elevated levels SP Interestingly, minimal overlap observed between signals, none areas rich neurofibrillary tangles (NFTs) or neuritic plaques (NP). In conclusion, lack correlation signals complex regulatory mechanisms deposition. These findings highlight complexity dysregulation potential progression.

Language: Английский

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Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 26, 2024

Abstract Quantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues’ susceptibility, including iron deposition and myelination. This study examines the relationship between subcortical volume determines specific differences in these among patients with major depressive disorder (MDD), schizophrenia, healthy controls (HCs). was cross-sectional study. Sex- age- matched MDD ( n = 49), schizophrenia 24), HCs 50) were included. Magnetic conducted using quantitative T1-weighted to measure volume. The acquired measurements compared groups analyses of variance post hoc comparisons. Finally, general linear model examined susceptibility–volume relationship. Significant group-level found nucleus accumbens amygdala p 0.045). Post-hoc indicated for group significantly higher than HC 0.0054, 0.0065, respectively). However, no significant groups. interaction but not or showed alterations patients. A observed group’s accumbens, which abnormalities myelination dopaminergic system related deposition.

Language: Английский

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Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer’s disease via the PI3K/Akt pathway

3 Biotech, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 1, 2025

Language: Английский

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Regional high iron deposition on brain quantitative susceptibility mapping correlates with cognitive decline in chronic kidney disease patients

Brain Imaging and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

This study aimed to evaluate changes in gray matter nuclei iron deposition chronic kidney disease (CKD) patients using the quantitative susceptibility mapping (QSM) threshold method, and analyze relationship between brain levels cognitive function. A total of fifty-three CKD were prospectively recruited, comprising 35 hemodialysis (HD, 57.54 ± 10.42 years, 21 males) 18 non-hemodialysis (NHD, 55.06 11.47 10 males ), compared 43 healthy controls (HC, 55.67 7.79 males). All participants underwent clinical assessments, neuropsychological tests, QSM scans. The mean magnetic value (MSV) volume whole (MSVM, VM) high region (MSVRII, VRII) measured. Correlations data, scores, variables HD group analyzed. Linear regression analysis was performed explore effect on cognition emotional well-being group. statistically significant P-value set at 0.05. exhibited higher MSVM right red nucleus (RN) HCs (P = 0.006). Additionally, differences MSVRII observed left caudate (CN), bilateral putamen (Put), RN among three groups (all P 0.027, FDR-corrected). Put positively correlated with creatinine uric acid levels, while negatively corpuscular hemoglobin concentration. Regression revealed that CN independently associated depression, delayed recall performance. Conversely, orientation ability, after controlling for age, sex, years education duration dialysis. Brain is often excessive uneven patients, particularly those undergoing hemodialysis. Assessing regional high-iron can provide valuable insights into distribution iron, which dysfunction disorders.

Language: Английский

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