American Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2024, Volume and Issue: 14(6), P. 371 - 390
Published: Jan. 1, 2024
Language: Английский
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e27950 - e27950
Published: March 26, 2024
Magnetic resonance imaging (MRI) techniques, such as quantitative susceptibility mapping (QSM) and susceptibility-weighted (SWI), can detect iron deposition in the brain. Iron accumulation putamen (PUT) contribute to pathogenesis of Parkinson's disease (PD) atypical Parkinsonian disorders. This systematic review aimed synthesize evidence on PUT assessed by MRI techniques PD Parkinsonism syndromes. The PubMed Scopus databases were searched for relevant studies. Thirty-four studies from January 2007 October 2023 that used QSM, SWI, or other methods measure putaminal PD, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), healthy controls (HCs) included. Most have found increased levels patients versus HCs based higher susceptibility. Putaminal correlates with worse motor scores cognitive decline PD. Evidence regarding differences between is emerging, several showing greater PSP MSA than patients. Alterations help distinguish these disorders Increased appear be associated severity progression. Thus, magnetic abnormal Parkinsonism. Moreover, quantifying may serve an biomarker monitor changes aid differential diagnosis
Language: Английский
Citations
10
Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 689 - 689
Published: April 16, 2024
Elevated levels of iron occur in both cortical and subcortical regions the CNS patients with Alzheimer’s disease. This accumulation is present early disease process as well more advanced stages. The factors potentially accounting for this increase are numerous, including: (1) Cells their uptake reduce export iron, becomes sequestered (trapped within lysosome, bound to amyloid β or tau, etc.); (2) metabolic disturbances, such insulin resistance mitochondrial dysfunction, disrupt cellular homeostasis; (3) inflammation, glutamate excitotoxicity, other pathological disturbances (loss neuronal interconnections, soluble β, etc.) trigger cells acquire iron; (4) following neurodegeneration, trapped microglia. Some these mechanisms also neurological disorders can begin course, indicating that a relatively common event conditions. In response pathogenic processes, directed efforts contribute buildup reflect importance correcting functional deficiency support essential biochemical processes. words, prioritize an insufficiency available while tolerating deposited iron. An analysis disease, relevant conditions, put forward.
Language: Английский
Citations
5
Journal of Magnetic Resonance Imaging, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Quantitative Susceptibility Mapping (QSM) provides a non-invasive post-processing method to investigate alterations in magnetic susceptibility (χ), reflecting iron content within brain regions implicated neurodegenerative diseases (NDDs). To thalamic χ patients with NDDs using QSM. Systematic review and meta-analysis. A total of 696 760 healthy controls (HCs) were included 27 studies. Three-dimensional multi-echo gradient echo sequence for QSM at mostly 3 Tesla. Studies reporting values the thalamus included. Following PRISMA 2020, we searched four major databases including PubMed, Scopus, Web Science, Embase peer-reviewed studies published until October 2024. Meta-analysis was conducted random-effects model calculate standardized mean difference (SMD) between HCs. The pooled SMD indicated significant increase compared HCs (SMD = 0.42, 95% CI: 0.05-0.79; k 27). Notably, amyotrophic lateral sclerosis showed (1.09, 0.65-1.53, 2) Subgroup analyses revealed younger (mean age ≤ 62 years; 0.56, 0.10-1.02, 11) greater coil channels (coil > 16; 0.64, 0.28-1.00, 9). Publication bias not detected quality assessment that lower risk presented more reliable findings (0.75, 0.32-1.18, Disease type primary driver heterogeneity, while other factors, such as geographic location, also contributed variability. Our support potential investigating involvement NDDs. Future research should focus on disease-specific patterns, thalamic-specific nucleus analysis, temporal evolution. investigated changes levels thalamus, region crucial motor cognitive functions, various study utilized specific resonance imaging technique called measure content. It identified NDD individuals. This particularly prominent Amyotrophic Lateral Sclerosis, individuals, employing advanced equipment. 2 TECHNICAL EFFICACY: Stage 2.
Language: Английский
Citations
0
Aging Medicine, Journal Year: 2025, Volume and Issue: 8(1)
Published: Feb. 1, 2025
ABSTRACT The complex interplay between diamagnetic and paramagnetic substances within the brain, particularly in context of Alzheimer's disease (AD), offers a rich landscape for investigation using advanced quantitative neuroimaging techniques. Although conventional approaches have focused on properties iron, emerging promising research has highlighted significance signatures associated with beta‐amyloid (Aβ) plaques Tau (τ) protein aggregates. Quantitative susceptibility mapping (QSM) is post‐processing technique that visualizes characterizes these subtle alterations brain border tissue composition, such as gray–white matter interface. Through voxel‐wise separation contributions sources, QSM enabled identification quantification Aβ τ aggregates, even presence iron. However, several challenges remain utilizing clinical applications. These include relatively small magnitude signal compared to need high‐resolution imaging sophisticated analysis techniques, standardization acquisition protocols. Further necessary refine optimize parameters, develop robust pipelines improve sensitivity specificity detecting nature As our understanding continues evolve, expected play pivotal role advancing knowledge AD other neurodegenerative diseases.
Language: Английский
Citations
0
Cerebral Cortex, Journal Year: 2025, Volume and Issue: 35(3)
Published: March 1, 2025
Abstract Evidence has linked head trauma to increased risk factors for neuropathology, including mechanical deformation of the sulcal fundus and, later, perivascular accumulation hyperphosphorylated tau adjacent these spaces related chronic traumatic encephalopathy. However, little is known about microstructural abnormalities and cellular dyshomeostasis in acute mild brain injury humans, particularly cortex. To address this gap, we designed first architectonically motivated quantitative susceptibility mapping study assess regional patterns net positive (iron-related) negative (myelin-, calcium-, protein-related) magnetic across 34 cortical regions interest following injury. Bilateral, between-group analyses sensitive depth curvature were conducted between 25 males with (<14 d) sports-related age-matched male controls. Results suggest a trauma-induced increase focal superficial, perivascular-adjacent parahippocampal sulcus. Decreases values distinct voxel populations within same region indicate potential dual pathology neural substrates. These injury–related from age-related processes revealed by correlation analyses. Our findings depth- curvature-specific deposition biological substrates tissue convergent features misfolded proteins trauma-related neurodegeneration.
Language: Английский
Citations
0
Ibrain, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract Iron accumulation in the prefrontal cortex (PFC) has been implicated neurodegeneration and cognitive decline. Magnetic resonance imaging (MRI) enables noninvasive quantification of brain iron content deposition. This review aimed to summarize evidence on MRI‐based assessment PFC healthy individuals patients with neurodegeneration. A systematic preliminary literature was conducted using PubMed, Scopus, Web Science, Embase databases. MRI techniques for capturing susceptibility changes reflecting iron, such as susceptibility‐weighted (SWI), quantitative mapping (QSM), R2* mapping, were included. Data extracted, narrative synthesis performed. Twelve studies that measured levels diseases (five studies) subjects (seven In general, involving have found increased correlates impairment. Aging reported age‐related particularly dorsolateral, medial, anterior subregions, increases age, is associated reduced dopamine signaling poorer cognition. techniques, QSM, can quantify aging. As biomarkers, may contribute Longitudinal combining advanced QSM other neuroimaging assessments further elucidate effects dysregulation function. Thus, our findings highlight importance a sensitive tool assessing its potential role understanding pathogenesis aging brain.
Language: Английский
Citations
0
Brain Imaging and Behavior, Journal Year: 2024, Volume and Issue: 18(5), P. 1239 - 1255
Published: May 17, 2024
Language: Английский
Citations
3
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 21, 2024
ABSTRACT Evidence has linked head trauma to increased risk factors for neuropathology, including acute mechanical deformation of the cortical sulcal fundus and, later, perivascular accumulation hyperphosphorylated tau (p-tau) adjacent these spaces related chronic traumatic encephalopathy (CTE). Despite this, little is known about microstructural abnormalities and cellular dyshomeostasis at stage mild brain injury (mTBI) in humans, particularly cortex. To address this gap literature, we designed first architectonically-motivated quantitative susceptibility mapping (QSM) study assess regional patterns positive (iron-related) negative (myelin-, calcium-, protein-related) magnetic regions interest (ROI) following mTBI. Depth- curvature-specific QSM values were compared between 25 males with (< 14 days) sports-related mTBI (sr-mTBI) age-matched male controls across 34 ROIs. Bilateral between-group analyses conducted on specific ROI curvature bins (crown, bank, fundus) as well a combined measure, 21 depths, each ROI. Correlations analysed age, severity, number days since injury. We observed significant group differences depth, curvature, Our results suggest trauma-induced pattern likely iron deposition preferential superficial, perivascular-adjacent sulci parahip-pocampal gyrus. Co-localised decreases diamagnetism same region dual pathology neural substrates, biological mechanisms behind which remain speculative. Significant correlations found both ROIs depths distinct from those showing sr-mTBI-related differences. Little no relationship was subjective markers or latency. The coherence our findings pathognomonic misfolded proteins trauma-related neurodegeneration interesting, may have implications role tissue damage after Further longitudinal research needed elucidate long-term findings.
Language: Английский
Citations
3
Aging Medicine, Journal Year: 2024, Volume and Issue: 7(5), P. 649 - 667
Published: Oct. 1, 2024
Abstract Alzheimer's disease (AD) is a neurodegenerative that characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral body iron dysregulation accumulation interact with AD pathology, particularly in the precuneus, crucial functional hub cognitive functions. Quantitative susceptibility mapping (QSM), novel post‐processing approach, provides insights into tissue levels oxygen metabolism reveals abnormal early AD. Increased deposition precuneus can lead to oxidative stress, neuroinflammation, accelerated neurodegeneration. Metabolic disorders (diabetes, non‐alcoholic fatty liver (NAFLD), obesity), genetic factors, small vessel pathology contribute precuneus. Therefore, line growing of literature region patients AD, QSM as neuroimaging method could serve non‐invasive biomarker track progression, complement other imaging modalities, aid diagnosis monitoring.
Language: Английский
Citations
3
Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 144, P. 56 - 67
Published: Sept. 10, 2024
Language: Английский
Citations
2