Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer’s disease model

IBRO Neuroscience Reports, Journal Year: 2023, Volume and Issue: 14, P. 264 - 272

Published: Jan. 26, 2023

Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian rhythms, aging and neuroprotection. levels are decreased in sporadic Alzheimer's disease (sAD) patients, which suggests relationship between melatonergic system sAD. may reduce inflammation, oxidative stress, TAU protein hyperphosphorylation, formation of β-amyloid (Aβ) aggregates. Therefore, objective this work was to investigate impact treatment 10 mg/kg melatonin (i.p) animal model sAD induced intracerebroventricular (ICV) infusion 3 streptozotocin (STZ). ICV-STZ causes changes brain rats similar those found patients These include; progressive memory decline, neurofibrillary tangles, senile plaques, disturbances glucose metabolism, insulin resistance even reactive astrogliosis characterized upregulation glial fibrillary acidic (GFAP). The results show that caused short-term spatial impairment after 30 days STZ without locomotor evaluated on day 27 post-injury. Furthermore, we observed prolonged 30-day improve cognitive animals Y-maze test, but not object location test. Finally, demonstrated receiving have high Aβ GFAP hippocampus reduces does levels, concluding useful control progression amyloid pathology brain.

Language: Английский

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A review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of the Astragalus memeranaceus

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 23, 2023

Astragali Radix (Huangqi) is mainly distributed in the Northern Hemisphere, South America, and Africa rarely North America Oceania. It has long been used as an ethnomedicine Russian Federation, Mongolia, Korea, Kazakhstan, China. was first recorded Shennong Ben Cao Jing includes effects of reinforcing healthy qi, dispelling pathogenic factors, promoting diuresis, reducing swelling, activating blood circulation, dredging collaterals. This review systematically summarizes botanical characteristics, phytochemistry, traditional uses, pharmacology, toxicology Astrag alus to explore potential Huangqi expand its applications. Data were obtained from databases such PubMed, CNKI, Wan Fang Data, Baidu Scholar, Google Scholar. The collected material also classic works Chinese herbal medicine, Pharmacopoeia, Medicine Dictionary, PhD Master’s theses. pharmacological isoflavone fraction have studied extensively; are reflected anti-inflammatory, anti-tumor, anti-oxidant, anti-allergic, anti-diabetic properties ability treat several related diseases. Additionally, medicinal chemical composition, activity, toxicology, quality control require further elucidation. Here, we provide a comprehensive botany, Astragalus assist future innovative research identify develop new drugs involving Huangqi.

Language: Английский

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Focusing on Formononetin: Recent Perspectives for its Neuroprotective Potentials

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: May 30, 2022

Nervous system is the most complex of human body, hence, neurological diseases often lack effective treatment strategies. Natural products have potential to yield unique molecules and produce integrative synergic effects compared standard therapy. Mounting evidence has shown that isoflavonoids contained in traditional medicinal plant or dietary supplementation may play a crucial role prevention due their pronounced biological activities correlating nervous system. Formononetin, non-steroidal isoflavonoid, bioactive constituent numerous plants such as red clover ( Trifolium pratense ) Astragalus membranaceus. Emerging formononetin possesses considerable anti-inflammatory, antioxidant anti-cancer effects. This review intends analyze neuropharmacological on therapy disorders. The neuroprotective properties are observed multiple disorders including Alzheimer’s disease, dementia, cerebral ischemia, traumatic brain injury, anxiety, depression. beneficial achieved partially through attenuating neuroinflammation oxidative stress via related signaling pathway. Despite its evident preclinical studies, definite humans still less known. More well-designed clinical trials required further confirm efficacy safety profile before application clinic.

Language: Английский

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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

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Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice

The FASEB Journal, Journal Year: 2020, Volume and Issue: 34(10), P. 14042 - 14054

Published: Sept. 10, 2020

Diabetes mellitus (DM) patients are at a higher risk of developing brain injury characterized by neuronal death. Melatonin, hormone produced the pineal gland, exerts neuroprotective effects against damage. However, effect melatonin on diabetes-induced has not been elucidated. This study was to evaluate role death in DM and elucidate underlying mechanisms. Herein, we found that administration significantly alleviated both streptozotocin (STZ)-induced diabetic mice high glucose (HG)-treated cells. Melatonin inhibited pyroptosis excessive autophagy, as evidenced decreased levels NLRP3, cleaved caspase-1, GSDMD-N, IL-1β, LC3, Beclin1, ATG12 vivo vitro. MicroRNA-214-3p (miR-214-3p) HG-treated cells, such downregulation corrected melatonin, which accompanied repression caspase-1 ATG12. Furthermore, miR-214-3p abrogated anti-pyroptotic anti-autophagic actions Our results indicate exhibits inhibiting autophagy through modulating miR-214-3p/caspase-1 miR-214-3p/ATG12 axes, respectively, it might be potential agent for treatment damage setting DM.

Language: Английский

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Melatonin in ventricular and subarachnoid cerebrospinal fluid: Its function in the neural glymphatic network and biological significance for neurocognitive health

Biochemical and Biophysical Research Communications, Journal Year: 2022, Volume and Issue: 605, P. 70 - 81

Published: March 17, 2022

Language: Английский

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Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1844 - 1844

Published: Oct. 10, 2023

The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, their role in stroke aging. Melatonin has garnered significant attention recent years due its diverse physiological functions potential therapeutic benefits by reducing oxidative stress, inflammation, apoptosis. been found mitigate ischemic brain damage caused stroke. By scavenging radicals damage, melatonin may help slow down aging process protect against age-related cognitive decline. Additionally, acids have shown possess neuroprotective properties, including antioxidant anti-inflammatory aging-related conditions. They can attenuate modulate calcium homeostasis, inhibit apoptosis, thereby safeguarding neurons induced processes. intracellular accumulation certain could promote harmful effects during hypoxia-ischemia episodes thus, blockade acid transporters involved be an alternative strategy reduce damage. On other hand, specifically mitochondrial reactive oxygen nitrogen species, accelerates cellular senescence contributes Recent research suggests a complex interplay actions converge on multiple pathways, regulation modulation reduction inflammation. These mechanisms collectively contribute preservation neuronal integrity functions, making them promising targets for interventions disorders.

Language: Английский

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Melatonin as a master regulatory hormone for genetic responses to biotic and abiotic stresses in model plant Arabidopsis thaliana: a comprehensive review

Functional Plant Biology, Journal Year: 2024, Volume and Issue: 51(2)

Published: Feb. 4, 2024

Melatonin is a naturally occurring biologically active amine produced by plants, animals and microbes. This review explores the biosynthesis of melatonin in with particular focus on its diverse roles Arabidopsis thaliana , model species. affects abiotic biotic stress resistance A. . Exogenous endogenous addressed association various conditions, including cold stress, high light intense heat infection Botrytis cinerea or Pseudomonas as well seed germination lateral root formation. Furthermore, confers initiating antioxidant system, remedying photosynthesis suppression, regulating transcription factors involved (CBF, DREB, ZAT, CAMTA, WRKY33, MYC2, TGA) other stress-related hormones (abscisic acid, auxin, ethylene, jasmonic acid salicylic acid). article additionally addresses precursors, metabolic components, expression genes (COR CBF SNAT ASMT PIN PR1 PDF1.2 HSFA ) proteins (JAZ, NPR1) associated reducing both biological environmental stressors. future perspective rich agri-crops explored to enhance plant tolerance stresses, maximise crop productivity nutritional worth, which may help improve food security.

Language: Английский

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Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

Biomolecules, Journal Year: 2021, Volume and Issue: 11(11), P. 1635 - 1635

Published: Nov. 4, 2021

Autism spectrum disorder (ASD) and Alzheimer’s disease (AD) are neurodevelopmental neurodegenerative disorders affecting two opposite ends of life span, i.e., childhood old age. Both pose a cumulative threat to human health, with the rate incidences increasing considerably worldwide. In context recent developments, we aimed review correlated symptoms genetics, overlapping aspects in mechanisms pathogenesis ASD AD. Dementia, insomnia, weak neuromuscular interaction, as well communicative cognitive impairments, shared symptoms. A number genes proteins linked both have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, FMR1. Theories about role neuron development, processing, connectivity, levels neurotransmitters discussed. Based on literature, roles FMRP (Fragile X mental retardation protein), hnRNPC (heterogeneous ribonucleoprotein-C), IRP (Iron regulatory proteins), miRNAs (MicroRNAs), α-, β0, γ-secretases posttranscriptional regulation cellular synthesis processing APP (amyloid-β precursor protein) elaborated describe parallel routes AD pathogenesis. However, interactive genetic environmental factors, oxidative metal ion stress, mutations associated genes, alterations related pathways development needs further investigation.

Language: Английский

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Progress in Research on the Effect of Melatonin on Postoperative Cognitive Dysfunction in Older Patients

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: March 9, 2022

Postoperative cognitive dysfunction (POCD) is a common complication of the central nervous system in elderly patients after operation. It will prolong length stay, reduce independence and quality daily life, increase risk death. However, at present, there lack safe effective ideal drugs for prevention treatment POCD. Melatonin one hormones secreted by pineal gland brain, which has functions regulating circadian rhythm, anti-inflammation, anti-oxidation, anti-apoptosis, so on. Some recent studies have shown that MT can prevent treat POCD adjusting restoring cholinergic function, neuroprotection, This article introduce POCD, melatonin mechanism on respectively, to provide basis clinical elderly.

Language: Английский

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