Quantitative proteomics of the miR-301a/SOCS3/STAT3 axis reveals underlying autism and anxiety-like behavior DOI Creative Commons
Xun Li,

Qi Fu,

Mingtian Zhong

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(1), P. 102136 - 102136

Published: Feb. 2, 2024

Autism is a widespread neurodevelopmental disorder. Although the research on autism spectrum disorders has been increasing in past decade, there still no specific answer to its mechanism of action and treatment. As pro-inflammatory microRNA, miR-301a abnormally expressed various psychiatric diseases including autism. Here, we show that deletion inhibition exhibited two distinct abnormal behavioral phenotypes mice. We observed mice impaired learning/memory, enhanced anxiety. On contrary, effectively reduced maternal immune activation (MIA)-induced autism-like behaviors further demonstrated bound 3′UTR region SOCS3, led upregulation SOCS3 hippocampus. The last result reduction inflammatory response by inhibiting phosphorylation AKT STAT3, expression level IL-17A poly(I:C)-induced features obtained data revealed as critical participant partial behavior phenotypes, which may exhibit divergent role between gene knockout knockdown. Our findings ascertain negatively regulates MIA-induced could present new therapeutic target for ameliorating abnormalities

Language: Английский

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment DOI Creative Commons
Muhammad Shahid Nadeem, Imran Kazmi, Inam Ullah

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 11(1), P. 87 - 87

Published: Dec. 30, 2021

Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic (Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S-allylcysteine sulfoxide) converted to allicin in an enzyme-mediated process catalysed alliinase. hydrophobic nature, can efficiently cross membranes and behaves as reactive sulfur species (RSS) inside cells. It physiologically active with ability oxidise thiol groups glutathione between cysteine residues proteins. has shown anticancer, antimicrobial, antioxidant properties also serves efficient therapeutic agent against cardiovascular diseases. In this context, present review describes antioxidant, neuroprotective that ameliorate cognitive abilities case neurodegenerative neuropsychological disorders. As fights oxygen (ROS) downregulation NOX (NADPH oxidizing) enzymes, it directly interact reduce levels different types ROS variety peroxidases. Most actions are mediated via redox-dependent pathways. inhibits neuroinflammation suppressing production, inhibition TLR4/MyD88/NF-κB, P38 JNK inhibitor cholinesterase (AChE) butyrylcholinesterase (BuChE) be applied manage Alzheimer’s disease, helps maintain balance neurotransmitters autism spectrum disorder (ASD) attention deficit hyperactive syndrome (ADHD). acute traumatic spinal cord injury (SCI) protects neuron damage regulating inflammation, apoptosis promoting expression Nrf2 (nuclear factor erythroid 2-related 2). Metal induced neurodegeneration attenuated patients suffering from neurological diseases ameliorates administration.

Language: Английский

Citations

76
Epidemiology of Alzheimer Disease and Related Dementia Among Medicare and Medicaid Enrolled Autistic Adults, 2011–2019 DOI
Salina Tewolde, Samuel B. Rosenberg, Josue Antonio Estrada

et al.

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

ABSTRACT Alzheimer's disease and related dementias (ADRD) are burdensome lethal conditions that have been hypothesized to be autism through shared genetic etiologies environmental risk factors. Our objective was use longitudinal Medicaid Medicare data describe the epidemiology of ADRD in publicly insured autistic adults. We used all claims encounters from 2011 2019 identify ADRD. calculated prevalence, incidence, age at onset, created survival curves. There were 90,229 adults ≥ 30 years enrolled for least 1 year and/or 267 cases. Prevalence 2.09% (95% CI: 1.99%, 2.20%) 8.11% 7.92%, 8.30%) 2019. Mean onset 59.3 (SD: 14.2). among men 58.3 13.8) 61.0 females. Incidence higher with intellectual disability no difference by sex. is a prevalent condition middle‐ older‐aged identified system. Understanding diagnostic process phenotype will important improve identification treatment.

Language: Английский

Citations

1
Neuronal Cell Adhesion Molecules May Mediate Neuroinflammation in Autism Spectrum Disorder DOI Creative Commons
Madeline Eve, Josan Gandawijaya, Liming Yang

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: April 15, 2022

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by restrictive and repetitive behaviors, alongside deficits in social interaction communication. The etiology of ASD largely unknown but strongly linked to genetic variants neuronal cell adhesion molecules (CAMs), cell-surface proteins that have important roles neurodevelopment. A combination environmental factors are believed contribute pathogenesis. Inflammation has been identified as one these factors, demonstrated through the presence proinflammatory cytokines, maternal immune activation, activation glial cells brains. Glial main source cytokines within brain and, therefore, their activity vital mediating inflammation central nervous system. However, it unclear whether aforementioned CAMs involved modulating neuroimmune signaling or behavior. This review aims address unexplored role may play inflammatory cascades underpin neuroinflammation ASD, primarily focusing on Notch, nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) cascades. We will also evaluate available evidence how influence associated with inflammation. when considering impact responses development. In particular, neural CAM1 (NCAM1) can regulate NF-κB transcription neurons, directly altering signaling. Additionally, NCAM1 contactin-1 appear mediate astrocyte oligodendrocyte precursor proliferation which alter response. Importantly, although this highlights limited information available, there CAM regulatory warrants further investigation into other family members would advance our understanding pathology.

Language: Английский

Citations

29
Protein modification in neurodegenerative diseases DOI Creative Commons

Shahin Ramazi,

Maedeh Dadzadi,

Mona Darvazi

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: Aug. 1, 2024

Abstract Posttranslational modifications play a crucial role in governing cellular functions and protein behavior. Researchers have implicated dysregulated posttranslational misfolding, which results cytotoxicity, particularly neurodegenerative diseases such as Alzheimer disease, Parkinson Huntington disease. These aberrant cause proteins to gather certain parts of the brain that are linked development diseases. This leads neuronal dysfunction start disease symptoms. Cognitive decline neurological impairments commonly manifest patients, underscoring urgency comprehending modifications’ impact on function for targeted therapeutic interventions. review elucidates critical link between specific modifications, focusing Tau, APP, α‐synuclein, Huntingtin protein, Parkin, DJ‐1, Drp1. By delineating prominent within underscores significance understanding interplay among these modifications. Emphasizing 10 key abnormal this study aims provide comprehensive framework investigating holistically. The insights presented herein shed light potential avenues aimed at modulating mitigate aggregation retard progression.

Language: Английский

Citations

4
Abamectin Causes Neurotoxicity in Zebrafish Embryos DOI Open Access
Zhang Hong-ying, Yulong Liu,

Yukun Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 349 - 349

Published: Jan. 3, 2025

Abamectin is an insecticide, miticide and nematicide that has been extensively used in agriculture for many years. The excessive use of abamectin inevitably pollutes water soil might even cause adverse effects on aquatic biota. However, it currently unclear how exposure causes neurotoxicity organisms. Herein, the early neural system development was assessed zebrafish embryos following exposure. After treatment with a concentration gradient (0.055, 0.0825, 0.11 mg/L), survival rate, average heart pericardial edema area yolk sac were all documented (96 hpf). It found after exposure, embryonic brain impaired, motor behaviors also affected. fluorescence intensity reduced transgenic (Eno2: GFP). activities acetylcholinesterase (AChE) ATPase decreased, expression neurodevelopment-related genes, such as sox10, gap43, grin1b, abat, gad1b, grin2b, nestin glsa, inhibited embryo abamectin. Furthermore, reactive oxygen species (ROS) triggered upon to along accumulation ROS, eventually resulting neuroapoptosis developing brain. In conclusion, neurodevelopmental toxicity caused by oxidative stress-induced apoptosis

Language: Английский

Citations

0
Autism and Dementia DOI
Emmanouil Dimarellis, Eleni Baldimtsi,

Zoi Varnali Kontopoulou

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 183 - 196

Published: Jan. 31, 2025

Autism Spectrum Disorder (ASD) and dementia are two distinct neurological conditions that affect millions of individuals worldwide. While they primarily diagnosed in different age groups—ASD being usually early childhood commonly older adults—there intriguing similarities their neurological, cognitive, behavioral profiles. Understanding these shared traits enriches the existing knowledge each condition enhances diagnostic therapeutic approaches. This chapter explores autism dementia, shedding light on implications for clinical practice.

Language: Английский

Citations

0
Machine learning uncovers novel sex-specific dementia biomarkers linked to autism and eye diseases DOI Creative Commons
Ayub Khan, Ali R. Ghasemi, Krista K. Ingram

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Background Recently, microRNAs (miRNAs) have attracted significant interest as predictive biomarkers for various types of dementia, including Alzheimer's disease (AD), vascular dementia (VaD), with Lewy bodies (DLB), normal pressure hydrocephalus (NPH), and mild cognitive impairment (MCI). Machine learning (ML) methods enable the integration miRNAs into highly accurate models dementia. Objective To investigate differential expression across subtypes compared to controls (NC) analyze their enriched biological pathways. Additionally, evaluate use these in binary multiclass ML prediction both overall sex-specific datasets. Methods Using data comprising 1685 Japanese individuals (GSE120584 GSE167559), we performed analysis identify associated five groups Pathway enrichment analyses were conducted further miRNAs. classifiers used create Results We identified novel differentially expressed miRNA distinguishing NC from subtypes. Incorporating resulted up a 27% improvement risk prediction. highlighted neuronal eye pathways risk. Sex-specific revealed unique males females, miR-128-1-5 protective factor AD, VaD, DLB, miR-4488 female highlighting distinct potential therapeutic targets each sex. Conclusions Our findings support existing etiology research introduce new biomarkers.

Language: Английский

Citations

0
Identification of Novel Candidate Loci for Alzheimer's Disease by Leveraging the Shared Genetic Basis with Hippocampal Volume DOI
Chenyang Jiang, Sven J. van der Lee, Niccoló Tesi

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Altered delay discounting in neurodegeneration: insight into the underlying mechanisms and perspectives for clinical applications DOI Creative Commons
Valérie Godefroy, Idil Sezer, Arabella Bouzigues

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 146, P. 105048 - 105048

Published: Jan. 18, 2023

Steeper delay discounting (i.e., the extent to which future rewards are perceived as less valuable than immediate ones) has been proposed a transdiagnostic process across different health conditions, in particular psychiatric disorders. Impulsive decision-making is hallmark of neurodegenerative conditions but little known about domain conditions. We reviewed studies on patients with Parkinson's disease (PD) and dementia (Alzheimer's / AD or frontotemporal FTD). that could be an early marker process. developed idea altered associated overlapping distinct neurocognitive mechanisms diseases: dopaminergic-related disorders reward processing PD, memory/projection deficits due medial temporal atrophy AD, modified orbitofrontal FTD. Neurodegeneration provide framework decipher neuropsychological value-based decision-making. Further, become interest clinical practice, for differential diagnosis.

Language: Английский

Citations

9
Vineland Adaptive Behavior Scale in a Cohort of Four ADNP Syndrome Patients Implicates Age-Dependent Developmental Delays with Increased Impact of Activities of Daily Living DOI
Joseph Levine,

Fahed Hakim,

R. Frank Kooy

et al.

Journal of Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 72(8), P. 1531 - 1546

Published: Aug. 1, 2022

Language: Английский

Citations

12