Annual Review of Neuroscience,
Journal Year:
2008,
Volume and Issue:
31(1), P. 339 - 358
Published: June 17, 2008
The
Wnt
family
of
secreted
proteins
plays
a
crucial
role
in
nervous
system
wiring.
Wnts
regulate
neuronal
positioning,
polarization,
axon
and
dendrite
development,
synaptogenesis.
These
diverse
roles
are
due
not
only
to
the
large
numbers
ligands
receptors
but
also
their
ability
signal
through
distinct
signaling
pathways
different
cell
types
developmental
contexts.
Studies
on
have
shed
new
light
novel
molecular
mechanisms
that
control
development
complex
connections.
This
review
discusses
recent
advances
how
influences
aspects
circuit
assembly
changes
gene
expression
and/or
cytoskeletal
modulation.
Diseases,
Journal Year:
2023,
Volume and Issue:
11(3), P. 89 - 89
Published: June 25, 2023
Wnt/β-catenin
(WβC)
signaling
pathway
is
an
important
for
the
maintenance
of
cellular
homeostasis
from
embryonic
developmental
stages
to
adulthood.
The
canonical
WβC
essential
neurogenesis,
cell
proliferation,
and
whereas
noncanonical
(WNT/Ca2+
WNT/PCP)
responsible
polarity,
calcium
maintenance,
migration.
Abnormal
regulation
involved
in
pathogenesis
several
neurodegenerative
diseases
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS),
multiple
(MS),
spinal
muscular
atrophy
(SMA).
Hence,
alteration
considered
a
potential
therapeutic
target
treatment
disease.
In
present
review,
we
have
used
bibliographical
information
PubMed,
Google
Scholar,
Scopus
address
current
prospects
role
abovementioned
diseases.
Annual Review of Cell and Developmental Biology,
Journal Year:
2007,
Volume and Issue:
23(1), P. 375 - 404
Published: June 25, 2007
Neuronal
motility
is
a
fundamental
feature
that
underlies
the
development,
regeneration,
and
plasticity
of
nervous
system.
Two
major
developmental
events--directed
migration
neuronal
precursor
cells
to
proper
positions
guided
elongation
axons
their
target
cells--depend
on
large-scale
motility.
At
finer
scale,
also
manifested
in
many
aspects
structures
functions,
ranging
from
differentiation
refinement
axonal
dendritic
morphology
during
development
synapse
remodeling
associated
with
learning
memory
adult
brain.
As
primary
second
messenger
conveys
cytoplasmic
actions
electrical
activity
neuroactive
ligands,
Ca(2+)
plays
central
role
regulation
Recent
studies
have
revealed
common
Ca(2+)-dependent
signaling
pathways
are
deployed
for
regulating
cytoskeletal
dynamics
migration,
axon
dendrite
synaptic
plasticity.
Annual Review of Neuroscience,
Journal Year:
2008,
Volume and Issue:
31(1), P. 339 - 358
Published: June 17, 2008
The
Wnt
family
of
secreted
proteins
plays
a
crucial
role
in
nervous
system
wiring.
Wnts
regulate
neuronal
positioning,
polarization,
axon
and
dendrite
development,
synaptogenesis.
These
diverse
roles
are
due
not
only
to
the
large
numbers
ligands
receptors
but
also
their
ability
signal
through
distinct
signaling
pathways
different
cell
types
developmental
contexts.
Studies
on
have
shed
new
light
novel
molecular
mechanisms
that
control
development
complex
connections.
This
review
discusses
recent
advances
how
influences
aspects
circuit
assembly
changes
gene
expression
and/or
cytoskeletal
modulation.
