Store-Operated CRAC Channels Regulate Gene Expression and Proliferation in Neural Progenitor Cells DOI Open Access
A. Somasundaram,

Andrew Shum,

Helen J. McBride

et al.

Journal of Neuroscience, Journal Year: 2014, Volume and Issue: 34(27), P. 9107 - 9123

Published: July 2, 2014

Calcium signals regulate many critical processes during vertebrate brain development including neurogenesis, neurotransmitter specification, and axonal outgrowth. However, the identity of ion channels mediating Ca2+ signaling in developing nervous system is not well defined. Here, we report that embryonic adult mouse neural stem/progenitor cells (NSCs/NPCs) exhibit store-operated entry (SOCE) mediated by release-activated (CRAC) channels. SOCE NPCs was blocked CRAC channel inhibitors La3+, BTP2, 2-APB Western blots revealed presence canonical proteins STIM1 Orai1. Knock down or Orai1 significantly diminished NPCs, lost from transgenic mice lacking knock-in expressing loss-of-function mutant, R93W. Therefore, make essential contributions to NPCs. activated epidermal growth factor acetylcholine, latter occurring through muscarinic receptors. Activation stimulated gene transcription calcineurin/NFAT (nuclear T cells) a mechanism consistent with local microdomains near Importantly, suppression deletion expression attenuated proliferation cultured as neurospheres and, in vivo, subventricular zone mice. These findings show serve major route key effector functions proliferation, indicating are important regulators mammalian neurogenesis.

Language: Английский

Random versus directionally persistent cell migration DOI
Ryan J. Petrie, Andrew D. Doyle, Kenneth M. Yamada

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2009, Volume and Issue: 10(8), P. 538 - 549

Published: July 15, 2009

Language: Английский

Citations

911
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity DOI Creative Commons
Gary A. Wayman, Yong‐Seok Lee, Hiroshi Tokumitsu

et al.

Neuron, Journal Year: 2008, Volume and Issue: 59(6), P. 914 - 931

Published: Sept. 1, 2008

Language: Английский

Citations

549
Wnt/Ca<sup>2+</sup> signaling pathway: a brief overview DOI

Antara De

Acta Biochimica et Biophysica Sinica, Journal Year: 2011, Volume and Issue: 43(10), P. 745 - 756

Published: Sept. 9, 2011

The non-canonical Wnt/Ca(2+) signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. Wnt pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 Wnt-Ror2 Wnt-PKA Wnt-GSK3MT Wnt-aPKC Wnt-RYK Wnt-mTOR and Wnt/calcium All these exhibit a considerable degree of overlap between them. pathway was deciphered crucial mediator in development. However, now there substantial evidence that involved many other molecular phenomena. Many aspects yet enigmatic. This review will give brief overview fundamental evolving concepts

Language: Английский

Citations

475
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks DOI
Eric C. Greenwald, Sohum Mehta, Jin Zhang

et al.

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(24), P. 11707 - 11794

Published: Dec. 14, 2018

Cellular signaling networks are the foundation which determines fate and function of cells as they respond to various cues stimuli. The discovery fluorescent proteins over 25 years ago enabled development a diverse array genetically encodable biosensors that capable measuring spatiotemporal dynamics signal transduction pathways in live cells. In an effort encapsulate breadth have expanded, we endeavored assemble comprehensive list published engineered biosensors, discuss many molecular designs utilized their development. Then, review how high temporal spatial resolution afforded by has aided our understanding regulation at cellular subcellular level. Finally, highlight some emerging areas research both biosensor design applications on forefront

Language: Английский

Citations

447
Role of Ion Channels and Transporters in Cell Migration DOI

Albrecht Schwab,

Anke Fabian,

Peter J. Hanley

et al.

Physiological Reviews, Journal Year: 2012, Volume and Issue: 92(4), P. 1865 - 1913

Published: Oct. 1, 2012

Cell motility is central to tissue homeostasis in health and disease, there hardly any cell the body that not motile at a given point its life cycle. Important physiological processes intimately related ability of respective cells migrate include embryogenesis, immune defense, angiogenesis, wound healing. On other side, migration associated with life-threatening pathologies such as tumor metastases atherosclerosis. Research from last ∼15 years revealed ion channels transporters are indispensable components cellular apparatus. After presenting general principles by which transport proteins affect migration, we will discuss systematically role involved migration.

Language: Английский

Citations

389
KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner DOI Creative Commons
Dante S. Bortone, Franck Polleux

Neuron, Journal Year: 2009, Volume and Issue: 62(1), P. 53 - 71

Published: April 1, 2009

Language: Английский

Citations

354
Axon Growth and Guidance: Receptor Regulation and Signal Transduction DOI
Michael P. O’Donnell, Rebecca K. Chance, Greg J. Bashaw

et al.

Annual Review of Neuroscience, Journal Year: 2009, Volume and Issue: 32(1), P. 383 - 412

Published: June 1, 2009

The development of precise connectivity patterns during the establishment nervous system depends on regulated action diverse, conserved families guidance cues and their neuronal receptors. Determining how these signaling pathways function to regulate axon growth is fundamentally important understanding wiring specificity in will undoubtedly shed light many neural developmental disorders. Considerable progress has been made defining mechanisms that correct spatial temporal distribution receptors turn signal cone cytoskeleton control steering decisions. This review focuses recent advances our mediating with a particular emphasis receptor regulation signaling.

Language: Английский

Citations

319
Calcium Signaling in Neuronal Development DOI Open Access

Sheila Rosenberg,

Nicholas C. Spitzer

Cold Spring Harbor Perspectives in Biology, Journal Year: 2011, Volume and Issue: 3(10), P. a004259 - a004259

Published: July 5, 2011

Sheila S. Rosenberg and Nicholas C. Spitzer Neurobiology Section, Division of Biological Sciences, Kavli Institute for Brain Mind, University California at San Diego, La Jolla, 92093 Correspondence: nspitzer{at}ucsd.edu

Language: Английский

Citations

282
Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions DOI Creative Commons
Heiko J. Luhmann, Anne Sinning, Jenq‐Wei Yang

et al.

Frontiers in Neural Circuits, Journal Year: 2016, Volume and Issue: 10

Published: May 24, 2016

Neuronal activity has been shown to be essential for the proper formation of neuronal circuits, affecting developmental processes like neurogenesis, migration, programmed cell death, cellular differentiation, local and long-range axonal connections, synaptic plasticity or myelination. Accordingly, neocortical areas reveal distinct spontaneous sensory-driven patterns already at early phases development. At embryonic stages, when immature neurons start develop voltage-dependent channels, is highly synchronized within small networks governed by electrical transmission. Subsequently, become more complex, involve larger propagate over several areas. The shift from large-scale network accompanied a gradual chemical transmission with an initial excitatory action chloride-gated channels activated GABA, glycine taurine. Transient populations in subplate support temporary circuits that play important role tuning mature networks. Thus, control developing sensory cortices, disturbances these may lead long-lasting deficits.

Language: Английский

Citations

251
Signaling from Axon Guidance Receptors DOI Open Access
Greg J. Bashaw, Rüdiger Klein

Cold Spring Harbor Perspectives in Biology, Journal Year: 2010, Volume and Issue: 2(5), P. a001941 - a001941

Published: March 24, 2010

Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental our understanding of nervous system development and may suggest new strategies promote regeneration after injury or disease. Signaling mechanisms that act downstream four prominent families cues--netrins, semaphorins, ephrins, slits--have been extensively studied in both invertebrate vertebrate model systems. Although details these signaling are still fragmentary there appears be considerable diversity different regulate the motility axonal growth cone, a number common themes have emerged. Here, we review recent insights into specific for each cues engage regulators cone cytoskeleton control guidance.

Language: Английский

Citations

231