Global trends in pesticides: A looming threat and viable alternatives

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 201, P. 110812 - 110812

Published: June 5, 2020

Language: Английский

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Neurotoxicity of pesticides

Acta Neuropathologica, Journal Year: 2019, Volume and Issue: 138(3), P. 343 - 362

Published: June 13, 2019

Language: Английский

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A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: Evidence of mechanisms, exposures and mitigation strategies

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 755, P. 142649 - 142649

Published: Oct. 1, 2020

Language: Английский

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Organophosphorus Compounds at 80: Some Old and New Issues

Toxicological Sciences, Journal Year: 2017, Volume and Issue: 162(1), P. 24 - 35

Published: Dec. 5, 2017

Abstract One of the major classes pesticides is that organophosphates (OPs). Initial developments date back almost 2 centuries but it was only in mid-1940s OPs reached a prominent status as insecticides, that, albeit declining, still ongoing. are highly toxic to nontarget species including humans, primary effects being an acute cholinergic toxicity (responsible for thousands poisoning each year) and delayed polyneuropathy. Several issues current debate investigation on toxicology discussed this brief review. These include (1) possible additional targets OPs, (2) developmental neurotoxicants, (3) neurodegenerative diseases, (4) “aerotoxic syndrome,” (5) microbiome, (6) cancer. Some these have been debated studied some time, while others newer, suggesting study will remain important scientific public health issue years come.

Language: Английский

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Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms

PLoS Medicine, Journal Year: 2018, Volume and Issue: 15(10), P. e1002671 - e1002671

Published: Oct. 24, 2018

In a Policy Forum, Irva Hertz-Picciotto and colleagues review the scientific evidence linking organophosphate pesticides to cognitive, behavioral, neurological deficits in children recommend actions reduce exposures.

Language: Английский

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Organic diet intervention significantly reduces urinary pesticide levels in U.S. children and adults

Environmental Research, Journal Year: 2019, Volume and Issue: 171, P. 568 - 575

Published: Feb. 12, 2019

Previous diet intervention studies indicate that an organic can reduce urinary pesticide metabolite excretion; however, they have largely focused on organophosphate (OP) pesticides. Knowledge gaps exist regarding the impact of exposure to other pesticides, including pyrethroids and neonicotinoids, which are increasing in use United States globally.To investigate levels insecticides, herbicides, fungicides or their metabolites urine collected from adults children.We samples four racially geographically diverse families before after (n = 16 participants a total 158 samples).We observed significant reductions thirteen parent compounds representing OP, neonicotinoid, pyrethroid insecticides herbicide 2,4-D following introduction diet. The greatest were for clothianidin (- 82.7%; 95% confidence interval [95% CI]: - 86.6%, 77.6%; p < 0.01), malathion dicarboxylic acid (MDA), 95.0%; CI: 97.0%, 91.8%; 3,5,6-trichlor-2-pyridinol (TCPy), chlorpyrifos 60.7%; 69.6%, 49.2%; 0.01). Metabolites boscalid, iprodione, thiabendazole neonicotinoid insecticide imidacloprid not detected among our study.An was associated with excretion several compounds. This study adds growing body literature indicating may range pesticides children adults. Additional research is needed evaluate dietary now most widely used class world.

Language: Английский

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Insights into the microbial degradation and biochemical mechanisms of carbamates

Chemosphere, Journal Year: 2021, Volume and Issue: 279, P. 130500 - 130500

Published: April 7, 2021

Language: Английский

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Establishment of an a priori protocol for the implementation and interpretation of an in‐vitro testing battery for the assessment of developmental neurotoxicity

EFSA Supporting Publications, Journal Year: 2020, Volume and Issue: 17(10)

Published: Oct. 1, 2020

In this project we set up a human cell-based DNTin vitro testing strategy that is based on test methods with high readiness and data generated therefrom. The underwent afit-for-purpose evaluation considered four key elements: 1. system, 2. the exposure scheme, 3. assay analytical endpoint(s) 4. classification model. This battery was challenged 119 chemicals for which rich toxicological information available (for some of them also their DNT hazard). Testing performed in 5 systems measuring 10 DNT-specific endpoints additional 9 viability/cytotoxicity-related parameters. For approximately half compounds, complementary from tests added by US-EPA. extended evaluated. results revealed current are reliable reproducible. had to large extent low redundancy. Battery performance, as assessed compounds well-characterized hazard sensitivity 82.7% specificity 88.2%. Gap analyses suggested radial, astro- microglia well myelination may be battery. Two case studies, one screening prioritization 14 flame retardants, characterization 2 pesticides, were presented. Hypothetical AOPs developed latter study.In conclusion, explored here very promising first approach identification characterization. performance encouraging improved inclusion further tests. Some uncertainties outcomes could reduced incorporating modelling approaches related vivo toxicokinetics compounds.

Language: Английский

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Effects of common environmental endocrine-disrupting chemicals on zebrafish behavior

Water Research, Journal Year: 2021, Volume and Issue: 208, P. 117826 - 117826

Published: Nov. 2, 2021

Language: Английский

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Review of rodent models of attention deficit hyperactivity disorder

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 132, P. 621 - 637

Published: Nov. 27, 2021

Language: Английский

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