Journal of Neuroscience,
Journal Year:
2014,
Volume and Issue:
34(2), P. 629 - 645
Published: Jan. 8, 2014
Axons
of
the
mammalian
CNS
lose
ability
to
regenerate
soon
after
development
due
both
an
inhibitory
environment
and
loss
cell-intrinsic
factors
necessary
for
regeneration.
The
complex
molecular
events
required
robust
regeneration
mature
neurons
are
not
fully
understood,
particularly
in
vivo
.
To
identify
genes
affecting
axon
Caenorhabditis
elegans
,
we
performed
RNAi-based
screen
defective
motor
unc-70
/β-spectrin
mutants
a
candidate
gene
screen.
From
these
screens,
identified
at
least
50
conserved
with
growth-promoting
or
growth-inhibiting
functions.
Through
our
analysis
mutants,
shed
new
light
on
certain
aspects
regeneration,
including
role
β-spectrin
membrane
dynamics,
antagonistic
activity
MAP
kinase
signaling
pathways,
stress
promoting
Many
candidates
had
previously
been
associated
implicate
pathways
interest
therapeutic
intervention.
Annual Review of Cell and Developmental Biology,
Journal Year:
2018,
Volume and Issue:
34(1), P. 495 - 521
Published: July 25, 2018
After
an
injury
in
the
adult
mammalian
central
nervous
system
(CNS),
lesioned
axons
fail
to
regenerate.
This
failure
regenerate
contrasts
with
axons'
remarkable
potential
grow
during
embryonic
development
and
after
peripheral
(PNS).
Several
intracellular
mechanisms-including
cytoskeletal
dynamics,
axonal
transport
trafficking,
signaling
transcription
of
regenerative
programs,
epigenetic
modifications-control
axon
regeneration.
In
this
review,
we
describe
how
manipulation
intrinsic
mechanisms
elicits
a
response
different
organisms
strategies
are
implemented
form
basis
future
treatment
CNS
injury.
PLoS ONE,
Journal Year:
2012,
Volume and Issue:
7(12), P. e52493 - e52493
Published: Dec. 26, 2012
Numerous
studies
have
shown
that
resistance
to
oxidative
stress
is
crucial
stay
healthy
and
reduce
the
adverse
effects
of
aging.
Accordingly,
nutritional
interventions
using
antioxidant
food-grade
compounds
or
food
products
are
currently
an
interesting
option
help
improve
health
quality
life
in
elderly.
Live
lactic
acid
bacteria
(LAB)
administered
food,
such
as
probiotics,
may
be
good
candidates.
Nevertheless,
information
about
LAB-induced
protection
scarce.
To
identify
characterize
new
potential
probiotic
strains,
we
developed
a
functional
screening
method
nematode
Caenorhabditis
elegans
host.
C.
were
fed
on
different
LAB
strains
(78
total)
viability
was
assessed
after
(3
mM
5
H2O2).
One
strain,
identified
Lactobacillus
rhamnosus
CNCM
I-3690,
protected
worms
by
increasing
their
30%
and,
also,
increased
average
worm
lifespan
20%.
Moreover,
transcriptomic
analysis
with
this
strain
showed
correlated
differential
expression
DAF-16/insulin-like
pathway,
which
highly
conserved
humans.
This
also
had
clear
anti-inflammatory
profile
when
co-cultured
HT-29
cells,
stimulated
pro-inflammatory
cytokines,
co-culture
systems
cells
DC
presence
LPS.
Finally,
reduced
inflammation
murine
model
colitis.
work
suggests
fast,
predictive
convenient
tool
for
subsequent
use
Genes & Development,
Journal Year:
2012,
Volume and Issue:
26(14), P. 1612 - 1625
Published: July 3, 2012
Both
cell-intrinsic
and
extrinsic
pathways
govern
axon
regeneration,
but
only
a
limited
number
of
factors
have
been
identified
it
is
not
clear
to
what
extent
regeneration
evolutionarily
conserved.
Whether
dendrites
also
regenerate
unknown.
Here
we
report
that,
like
the
axons
mammalian
sensory
neurons,
certain
Drosophila
dendritic
arborization
(da)
neurons
are
capable
substantial
in
periphery
CNS,
activating
Akt
pathway
enhances
CNS.
Moreover,
those
da
display
dendrite
which
cell
type-specific,
developmentally
regulated,
associated
with
microtubule
polarity
reversal.
Dendrite
restrained
via
inhibition
by
epithelial
cell-derived
microRNA
bantam
facilitated
cell-autonomous
activation
pathway.
Our
study
begins
reveal
mechanisms
for
depends
on
both
intrinsic
factors,
including
PTEN–Akt
that
important
regeneration.
We
thus
established
an
new
model
system—the
fly
neuron
resembles
injury
model—with
gain
novel
insights
into
machinery.
