Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System DOI Creative Commons
Feng Li,

Armin Sami,

Harun N. Noristani

et al.

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(5), P. 767 - 785.e7

Published: Sept. 16, 2020

Language: Английский

Intrinsic Control of Axon Regeneration DOI Creative Commons
Zhigang He, Yishi Jin

Neuron, Journal Year: 2016, Volume and Issue: 90(3), P. 437 - 451

Published: May 1, 2016

Language: Английский

Citations

556
Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes DOI Creative Commons
Nicholas M. Tran, Karthik Shekhar,

Irene E. Whitney

et al.

Neuron, Journal Year: 2019, Volume and Issue: 104(6), P. 1039 - 1055.e12

Published: Nov. 26, 2019

Language: Английский

Citations

529
Intrinsic mechanisms of neuronal axon regeneration DOI
Marcus Mahar, Valeria Cavalli

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(6), P. 323 - 337

Published: April 17, 2018

Language: Английский

Citations

510
Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes DOI Creative Commons
Bruce A. Rheaume,

Amyeo Jereen,

Mohan Bolisetty

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: July 11, 2018

Retinal ganglion cells (RGCs) convey the major output of information collected from eye to brain. Thirty subtypes RGCs have been identified date. Here, we analyze 6225 (average 5000 genes per cell) right and left eyes by single-cell RNA-seq classify them into 40 using clustering algorithms. We identify additional markers, as well transcription factors predicted cooperate in specifying RGC subtypes. Zic1, a marker eye-enriched subtype, is validated immunostaining situ. Runx1 Fst, markers other subtypes, are purified fluorescent situ hybridization (FISH) immunostaining. show extent gene expression variability needed for subtype segregation, hierarchy diversification cell-type population Finally, present website comparing

Language: Английский

Citations

390
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System DOI Creative Commons
Yi‐Lan Weng, Xu Wang, Ran An

et al.

Neuron, Journal Year: 2018, Volume and Issue: 97(2), P. 313 - 325.e6

Published: Jan. 1, 2018

Language: Английский

Citations

352
Restoration of Visual Function by Enhancing Conduction in Regenerated Axons DOI Creative Commons
Fengfeng Bei, Henry H.C. Lee, Xuefeng Liu

et al.

Cell, Journal Year: 2016, Volume and Issue: 164(1-2), P. 219 - 232

Published: Jan. 1, 2016

Language: Английский

Citations

240
Injured adult neurons regress to an embryonic transcriptional growth state DOI
Gunnar Poplawski, Riki Kawaguchi,

Erna van Niekerk

et al.

Nature, Journal Year: 2020, Volume and Issue: 581(7806), P. 77 - 82

Published: April 15, 2020

Language: Английский

Citations

211
Reaching the brain: Advances in optic nerve regeneration DOI
Larry I. Benowitz, Zhigang He, Jeffrey L. Goldberg

et al.

Experimental Neurology, Journal Year: 2015, Volume and Issue: 287, P. 365 - 373

Published: Dec. 31, 2015

Language: Английский

Citations

206
Solving neurodegeneration: common mechanisms and strategies for new treatments DOI Creative Commons
Lauren K. Wareham, Shane A. Liddelow, Sally Temple

et al.

Molecular Neurodegeneration, Journal Year: 2022, Volume and Issue: 17(1)

Published: March 21, 2022

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology site disease pathology. To address these and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus the Melza M. Frank Theodore Barr Foundation collaborated to bring together key opinion leaders experts field for a virtual meeting titled "Solving Neurodegeneration". This "think-tank" style focused uncovering mechanistic roots promising new catalyzed by goal finding treatments glaucoma, world's leading cause irreversible blindness interest three hosting foundations. Glaucoma, which causes vision loss through degeneration optic nerve, likely shares early cellular molecular events with other diseases central nervous system. Here we major areas overlap between system: neuroinflammation, bioenergetics metabolism, genetic contributions, neurovascular interactions. We summarize important discussion points emphasis research that are most innovative treatment neurodegeneration yet require further development. The is highlighted provides unique opportunities collaboration will lead efforts preventing ultimately loss.

Language: Английский

Citations

196
Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside DOI

Michele Curcio,

Frank Bradke

Annual Review of Cell and Developmental Biology, Journal Year: 2018, Volume and Issue: 34(1), P. 495 - 521

Published: July 25, 2018

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure regenerate contrasts with axons' remarkable potential grow during embryonic development and after peripheral (PNS). Several intracellular mechanisms-including cytoskeletal dynamics, axonal transport trafficking, signaling transcription of regenerative programs, epigenetic modifications-control axon regeneration. In this review, we describe how manipulation intrinsic mechanisms elicits a response different organisms strategies are implemented form basis future treatment CNS injury.

Language: Английский

Citations

189