Cell transplantation therapy for spinal cord injury

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(5), P. 637 - 647

Published: April 25, 2017

Language: Английский

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Intrinsic mechanisms of neuronal axon regeneration

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(6), P. 323 - 337

Published: April 17, 2018

Language: Английский

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Cell biology of spinal cord injury and repair

Journal of Clinical Investigation, Journal Year: 2017, Volume and Issue: 127(9), P. 3259 - 3270

Published: July 23, 2017

Spinal cord injury (SCI) lesions present diverse challenges for repair strategies. Anatomically complete injuries require restoration of neural connectivity across lesions. incomplete may benefit from augmentation spontaneous circuit reorganization. Here, we review SCI cell biology, which varies considerably three different lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (c) surrounding spared but reactive tissue. After SCI, axon growth reorganization are determined by neuron-cell-autonomous mechanisms interactions among neurons, glia, immune other cells. These shaped both the presence absence growth-modulating molecules, vary markedly in compartments. The emerging understanding how biology differs compartments is fundamental to developing rationally targeted

Language: Английский

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Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 15(4), P. 193 - 203

Published: Jan. 30, 2019

Language: Английский

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Required growth facilitators propel axon regeneration across complete spinal cord injury

Nature, Journal Year: 2018, Volume and Issue: 561(7723), P. 396 - 400

Published: Aug. 28, 2018

Language: Английский

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Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

Neuron, Journal Year: 2020, Volume and Issue: 108(1), P. 128 - 144.e9

Published: Aug. 17, 2020

Language: Английский

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Spinal cord repair: advances in biology and technology

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(6), P. 898 - 908

Published: June 1, 2019

Language: Английский

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Microglia-organized scar-free spinal cord repair in neonatal mice

Nature, Journal Year: 2020, Volume and Issue: 587(7835), P. 613 - 618

Published: Oct. 7, 2020

Language: Английский

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Dissecting spinal cord regeneration

Nature, Journal Year: 2018, Volume and Issue: 557(7705), P. 343 - 350

Published: May 8, 2018

Language: Английский

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Spinal cord injury: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 26, 2023

Abstract Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties neural regeneration in central nervous system. In past few decades, researchers have attempted to completely elucidate mechanism identify effective strategies promote axon circuit remodeling, but results not been ideal. Recently, new SCI, especially interactions between immune cell responses, revealed by single-cell sequencing spatial transcriptome analysis. With development bioactive materials stem cells, more attention has focused on forming intermediate networks reconstruction than promoting axonal corticospinal tract. Furthermore, technologies control physical parameters such as electricity, magnetism ultrasound constantly innovated applied fate regulation. Among these advanced novel technologies, therapy, biomaterial transplantation, electromagnetic stimulation entered into stage clinical trials, some them already treatment. this review, we outline overall epidemiology pathophysiology expound latest research progress related detail, propose future directions for applications.

Language: Английский

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