Neural mechanisms and temporal dynamics of performance monitoring

Trends in Cognitive Sciences, Journal Year: 2014, Volume and Issue: 18(5), P. 259 - 267

Published: March 22, 2014

Language: Английский

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Arithmetic and local circuitry underlying dopamine prediction errors

Nature, Journal Year: 2015, Volume and Issue: 525(7568), P. 243 - 246

Published: Aug. 31, 2015

Language: Английский

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Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics

Journal of Neuroscience, Journal Year: 2015, Volume and Issue: 35(8), P. 3607 - 3615

Published: Feb. 25, 2015

Previous rodent studies have implicated the infralimbic (IL) subregion of medial prefrontal cortex in extinction auditory fear conditioning. However, these used pharmacological inactivation or electrical stimulation techniques, which lack temporal precision and neuronal specificity. Here, we an optogenetic approach to either activate (with channelrhodopsin) silence halorhodopsin) glutamatergic IL neurons during conditioned tones delivered one two phases: training retrieval. Activating reduced expression strengthened memory following day. Silencing had no effect on within-session extinction, but impaired retrieval day, indicating that activity is necessary for formation memory. Surprisingly, however, silencing optogenetically pharmacologically 1 day week effect. Our findings suggest likely facilitates storage target structures, contrary current models, does not appear be

Language: Английский

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Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

Neuron, Journal Year: 2018, Volume and Issue: 97(2), P. 434 - 449.e4

Published: Jan. 1, 2018

Language: Английский

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Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry

Neuron, Journal Year: 2015, Volume and Issue: 88(2), P. 247 - 263

Published: Oct. 1, 2015

Language: Английский

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