Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(8), P. 1180 - 1188
Published: June 19, 2017
Language: Английский
Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(8), P. 1180 - 1188
Published: June 19, 2017
Language: Английский
Science, Journal Year: 2018, Volume and Issue: 360(6396)
Published: May 31, 2018
Imaging dopamine release in the brain Neuromodulator alters function of target circuits poorly known ways. An essential step to address this knowledge gap is measure dynamics neuromodulatory signals while simultaneously manipulating elements circuit during behavior. Patriarchi et al. developed fluorescent protein–based indicators visualize spatial and temporal directly with high fidelity resolution. In cortex, two-photon imaging these was used map activity at cellular Science , issue p. eaat4422
Language: Английский
Citations
987Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(3), P. 404 - 413
Published: Feb. 23, 2016
Language: Английский
Citations
921Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(8), P. 482 - 494
Published: June 6, 2019
Language: Английский
Citations
493Scientific Data, Journal Year: 2018, Volume and Issue: 5(1)
Published: April 17, 2018
Abstract Recent advances in magnetic resonance imaging methods, including data acquisition, pre-processing and analysis, have benefited research on the contributions of subcortical brain nuclei to human cognition behavior. At same time, these developments led an increasing need for a high-resolution probabilistic vivo anatomical atlas nuclei. In order address this need, we constructed high spatial resolution, three-dimensional templates, using high-accuracy diffeomorphic registration T 1 - 2 weighted structural images from 168 typical adults between 22 35 years old. many tissue boundaries are clearly visible, which would otherwise be impossible delineate individual studies. The resulting delineations complement current histology-based atlases. We further created companion library software tools development, offer open evolving resource creation crowd-sourced brain.
Language: Английский
Citations
452Annual Review of Neuroscience, Journal Year: 2017, Volume and Issue: 40(1), P. 479 - 498
Published: May 10, 2017
Trial-to-trial variability in the execution of movements and motor skills is ubiquitous widely considered to be unwanted consequence a noisy nervous system. However, recent studies have suggested that may also feature how sensorimotor systems operate learn. This view, rooted reinforcement learning theory, equates with purposeful exploration space that, when coupled reinforcement, can drive learning. Here we review explore relationship between both humans animal models. We discuss neural circuit mechanisms underlie generation regulation consider implications this work has for our understanding
Language: Английский
Citations
443Trends in Cognitive Sciences, Journal Year: 2019, Volume and Issue: 23(3), P. 213 - 234
Published: Jan. 31, 2019
Language: Английский
Citations
442Annual Review of Neuroscience, Journal Year: 2017, Volume and Issue: 40(1), P. 373 - 394
Published: April 25, 2017
Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine make this calculation. Here we review studies that tackle problem from a diverse set approaches, anatomy to electrophysiology computational modeling behavior. Several patterns emerge synthesis: themselves calculate rather than inherit passively upstream regions; they combine multiple separate redundant inputs, which are interconnected in dense recurrent network; despite complexity output is remarkably homogeneous robust. The more study simple arithmetic computation, knottier appears be, suggesting daunting (but stimulating) path ahead for neuroscience generally.
Language: Английский
Citations
408Nature, Journal Year: 2020, Volume and Issue: 577(7792), P. 671 - 675
Published: Jan. 15, 2020
Language: Английский
Citations
390Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(8), P. 1072 - 1083
Published: July 19, 2018
Language: Английский
Citations
387Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(10), P. 1421 - 1430
Published: Aug. 21, 2018
Language: Английский
Citations
346