Reassessing Models of Basal Ganglia Function and Dysfunction

Annual Review of Neuroscience, Journal Year: 2014, Volume and Issue: 37(1), P. 117 - 135

Published: July 8, 2014

The basal ganglia are a series of interconnected subcortical nuclei. function and dysfunction these nuclei have been studied intensively in motor control, but more recently our knowledge functions has broadened to include prominent roles cognition affective control. This review summarizes historical models function, as well findings supporting or conflicting with models, while emphasizing recent work animals humans directly testing the hypotheses generated by models.

Language: Английский

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Opponent and bidirectional control of movement velocity in the basal ganglia

Nature, Journal Year: 2016, Volume and Issue: 533(7603), P. 402 - 406

Published: April 29, 2016

Language: Английский

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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

Nature Communications, Journal Year: 2014, Volume and Issue: 5(1)

Published: Oct. 31, 2014

Language: Английский

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The basolateral amygdala in reward learning and addiction

Neuroscience & Biobehavioral Reviews, Journal Year: 2015, Volume and Issue: 57, P. 271 - 283

Published: Sept. 2, 2015

Language: Английский

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Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons

Frontiers in Neuroanatomy, Journal Year: 2015, Volume and Issue: 9

Published: March 27, 2015

Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of hypothalamus and tractus solitarius (NTS) brainstem play important roles suppressing food intake maintaining energy homeostasis. Previous tract-tracing studies have revealed axonal connection patterns these two brain areas, but intermingling POMC with other neuron types has made it challenging to precisely identify inputs outputs neurons. In this study, we used modified rabies virus map areas that provide direct ARC NTS as well AgRP for comparison. receive from dozens discrete structures throughout forebrain brainstem. The containing presynaptic partners largely overlap those neurons, although relatively broader, denser inputs. Furthermore, predominantly show very different innervation ARC. By selectively expressing fluorescent markers found almost all their major are innervated by suggesting there strong reciprocal projections among neural pathways. comprehensively chartering whole-brain connections central melanocortin system a cell-type-specific manner, study lays foundation dissecting underlying circuit mechanisms specific pathways regulating

Language: Английский

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What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 42(1), P. 459 - 483

Published: April 24, 2019

Deciding what to do and when move is vital our survival. Clinical fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the ganglia, striatum, receives inputs from frontal, sensory, motor cortices interconnected thalamic areas that provide information about potential goals, context, actions directly or indirectly modulates outputs. striatum also dopaminergic can signal reward prediction errors behavioral transitions movement initiation. Here we review models how direct indirect pathways modulate outputs facilitate initiation, discuss role cortical in determining if it. Complex but exciting scenarios emerge shed new light on self-paced

Language: Английский

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Neurobiology of Resilience: Interface Between Mind and Body

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 86(6), P. 410 - 420

Published: April 17, 2019

Language: Английский

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Striatal Circuits as a Common Node for Autism Pathophysiology

Frontiers in Neuroscience, Journal Year: 2016, Volume and Issue: 10

Published: Feb. 9, 2016

Autism spectrum disorders (ASD) are characterized by two seemingly unrelated symptom domains-deficits in social interactions and restrictive, repetitive patterns of behavioral output. Whether the diverse nature ASD symptomatology represents distributed dysfunction brain networks or abnormalities within specific neural circuits is unclear. Striatal postulated to underlie motor behaviors seen ASD, neurological brain-imaging studies have supported this assumption. However, as our appreciation striatal function expands include regulation flexibility, motivational state, goal-directed learning, attention, we consider whether alterations physiology a central node mediating range autism-associated behaviors, including cognitive deficits that hallmarks disease. This review investigates multiple genetic mouse models explore constitute common pathophysiological mechanism development autism-related behaviors. Despite heterogeneity insult investigated, numerous display structure circuits, well abnormal grooming, stereotypic routines, interaction decision-making. Comparative analysis rodents provides unique opportunity leverage growing association data reveal canonical whose directly contributes discrete aspects symptomatology. The description such could provide both organizing principles for understanding complex etiology novel treatment routes. Furthermore, focus on mechanisms may also prove useful exploring pathogenesis other neuropsychiatric diseases, which overlapping with ASD.

Language: Английский

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An interactive framework for whole-brain maps at cellular resolution

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 21(1), P. 139 - 149

Published: Dec. 2, 2017

Language: Английский

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Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation

Neuron, Journal Year: 2016, Volume and Issue: 90(6), P. 1312 - 1324

Published: May 28, 2016

Language: Английский

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