Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification

Journal of Pain, Journal Year: 2016, Volume and Issue: 17(9), P. T93 - T107

Published: Aug. 30, 2016

Language: Английский

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Chronic Pain and Mental Health Disorders

Mayo Clinic Proceedings, Journal Year: 2016, Volume and Issue: 91(7), P. 955 - 970

Published: June 24, 2016

Language: Английский

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Deconstructing the sensation of pain: The influence of cognitive processes on pain perception

Science, Journal Year: 2016, Volume and Issue: 354(6312), P. 584 - 587

Published: Nov. 3, 2016

Phenomena such as placebo analgesia or pain relief through distraction highlight the powerful influence cognitive processes and learning mechanisms have on way we perceive pain. Although contemporary models of acknowledge that is not a direct readout nociceptive input, neuronal underlying modulation are yet fully understood. Modern concepts perception—which include computational modeling to quantify processes—suggest perception critically determined by expectations their modification learning. Research has just begun embrace this view. Insights into these promise open up new avenues prevention treatment harnessing power mind.

Language: Английский

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Brain Rhythms of Pain

Trends in Cognitive Sciences, Journal Year: 2016, Volume and Issue: 21(2), P. 100 - 110

Published: Dec. 23, 2016

Pain is a vital phenomenon that depends on the dynamic integration of sensory and contextual processes. In chronic pain adaptive processes severely disturbed. Neuronal oscillations synchrony at different frequencies provide evidence information flow across brain areas. The flexible relationship between indicates routing in cerebral processing pain. systematic assessment provides insights into how are flexibly integrated coherent percept abnormalities these Predictive coding frameworks might help us understand an integrative results from interactions (i.e., cognitive, emotional, motivational) experience associated with neuronal frequencies. However, overarching framework for significance remains lacking. Recent concepts relate to signaling predictions prediction errors. application promises coordinates diverse merge Such have implications understanding treatment [1Melzack R. Casey K.L. Sensory, motivational, central control determinants pain: new conceptual model pain.in: Kenshalo D.R.J. Skin Senses. Charles C. Thomas, 1968: 423-439Google Scholar]. thus essentially phenomenon. recent years it has been shown serve functions by [2Schnitzler A. Gross J. Normal pathological oscillatory communication brain.Nat. Rev. Neurosci. 2005; 6: 285-296Crossref PubMed Scopus (618) Google Scholar, 3Akam T. Kullmann D.M. Oscillatory multiplexing population codes selective mammalian 2014; 15: 111-122Crossref (75) 4Fries P. Rhythms cognition: through coherence.Neuron. 2015; 88: 220-235Abstract Full Text PDF (182) 5Saalmann Y.B. et al.The pulvinar regulates transmission cortical areas based attention demands.Science. 2012; 337: 753-756Crossref (298) 6Mejias J.F. al.Feedforward feedback frequency-dependent large-scale laminar network primate cortex.Sci. Adv. 2016; 2: e1601335Crossref Thus, role functionally dynamically health disease. Here we review We begin brief discussion peculiarities its brain. then summarize On this basis specifically discuss factors percept. Moreover, Finally, consider perspectives future directions study unpleasant emotional signals threat promotes behavior protect individual. Commonly, underlying process noxious stimulus induces physiological processes, referred as nociception (see Glossary), translate This translation influenced broad variety factors. routinely make use influence; example, when comforting injured child or harnessing placebo effects therapy. nociceptive mediated feedforward human [7Wiech K. Deconstructing sensation influence cognitive perception.Science. 354: 584-587Crossref (0) not static but be adjusted continuously changing demands everyday life. For same input can yield no competing goal achieved (e.g., during long-distance run) under other conditions result strong severe disease feared). plays preeminent probably exceeds modalities. states, often persists without objective body. Chronic own right affects about fifth adult Western world [8Breivik H. al.Survey Europe: prevalence, impact daily life, treatment.Eur. Pain. 2006; 10: 287-333Crossref (1993) 9Kennedy al.Prevalence persistent U.S. population: data 2010 national interview survey.J. 979-984Abstract (46) Scholar], imposes enormous economic burden society [10Breivik individual societal case strategic prioritisation action improve knowledge availability appropriate care.BMC Public Health. 2013; 13: 1229Crossref (93) 11Gaskin D.J. Richard costs United States.J. 715-724Abstract (470) causes suffering individuals. weak lost [12Baliki M.N. Apkarian A.V. Nociception, pain, negative moods, selection.Neuron. 87: 474-491Abstract Scholar] indicating abnormal information. particular, there close mutual [13Flor Turk D.C. IASP Press, 2011Google certain psychological such passive coping strategies predispose development and, conversely, yields affective, functional deficits disturbed activation extended including somatosensory, insular, cingulate, prefrontal cortices, thalamus, subcortical areas, brainstem [14Apkarian al.Human mechanisms perception regulation disease.Eur. 9: 463-484Crossref (1508) These do constitute dedicated system belong systems transiently orchestrated None exclusively singularly determines [15Legrain V. matrix reloaded: salience detection body.Prog. Neurobiol. 2011; 93: 111-124Crossref (317) [16Segerdahl A.R. dorsal posterior insula subserves fundamental pain.Nat. 18: 499-500Crossref 17Davis K.D. al.Evidence against specificity insula.F1000Res. 4: 362Crossref 18Lieberman M.D. Eisenberger N.I. anterior cingulate cortex reverse inference.Proc. Natl. Acad. Sci. U.S.A. 112: 15250-15255Crossref (11) 19Wager T.D. al.Pain ACC?.Proc. 113: E2474-E2475Crossref ongoing topic). It likely activity eventually Structural connections represent anatomical process. adjust momentary behavioral demands, highly flexible. flexibility requires changes timescales provided structural rather connections. recently conceptualized connectome [20Kucyi Davis connectome.Trends 38: 86-95Abstract concept does conceive emphasizes dynamics determine only spatially recruited also complex temporal–spectral patterns activity. pain-related ranging infraslow fluctuations below 0.1 Hz (Box 1) via theta (4–7 Hz), alpha (8–13 beta (14–29 Hz) gamma (30–100 [21Gross al.Gamma primary somatosensory reflect perception.PLoS Biol. 2007; 5: e133Crossref (53) 22Hauck M. al.Attention painful stimulation enhances gamma-band synchronization sensorimotor cortex.J. 27: 9270-9277Crossref (74) 23Mouraux al.Non-phase locked electroencephalogram (EEG) responses CO2 laser skin stimulations may A∂- C-fibre afferent volleys.Clin. Neurophysiol. 2003; 114: 710-722Abstract 24Ploner suppresses spontaneous rhythms.Cereb. Cortex. 16: 537-540Crossref 25Zhang Z.G. al.Gamma-band – direct obligatory correlate subjective intensity.J. 32: 7429-7438Crossref 26Baliki rhythms back pain.J. 31: 13981-13990Crossref (104) 27Malinen S. al.Aberrant temporal spatial rest patients pain.Proc. 2010; 107: 6493-6497Crossref 28Napadow al.Decreased intrinsic connectivity reduced clinical fibromyalgia.Arthritis Rheum. 64: 2398-2403Crossref (101) 29Alshelh Z. al.Chronic neuropathic it's rhythm.J. 36: 1008-1018Crossref 30Green A.L. al.Neural signatures pain.Neurology. 2009; 72: 569-571Crossref 31Huang Y. al.Characteristics local field potentials relief deep stimulation.Clin. 127: 2573-2580Abstract observed. recorded timescales. lacking.Box 1Infraslow Fluctuations PainIn resting-state fMRI data, blood oxygenation level-dependent (BOLD) observed [108Raichle M.E. restless brain: organizes function.Philos. Trans. Soc. Lond. B (Published online May 19, 2015)https://doi.org/10.1016/10.1098/rstb.2014.0172Crossref defines networks Accumulating particularly activities default mode, salience, changed [26Baliki findings show within [109Hemington K.S. al.Abnormal cross-network association symptoms.Brain Struct. Funct. 221: 4203-4219Crossref (17) frequency pattern variability [110Rogachov al.Regional signal variability: novel indicator sensitivity coping.Pain. 157: 2483-2492Crossref analysis promising approach advance our BOLD found many neuropsychiatric disorders [111Greicius Resting-state disorders.Curr. Opin. Neurol. 2008; 21: 424-430Crossref so symptom important question.Two aspects particular interest First, slowly propagating waves timescale 1 s whole [112Mitra al.Lag threads organize brain's activity.Proc. E2235-E2244Crossref 113Matsui al.Transient coactivations embedded globally underlie connectivity.Proc. 6556-6561Crossref subthreshold depolarization neurons modulation excitability [114Wu J.Y. al.Propagating neocortex: what they are, do.Neuroscientist. 14: 487-502Crossref Changes therefore indicate impairment waves. As intimately linked slow sleep memory consolidation [115Mitra al.Propagated infra-slow reorganizes wake wave sleep.Elife. 10781Crossref learning Second, faster [116Mantini D. al.Electrophysiological resting state brain.Proc. 104: 13170-13175Crossref (923) 117Brookes M.J. al.Investigating electrophysiological using magnetoencephalography.Proc. 108: 16783-16788Crossref (310) cross-frequency coupling shaping oscillations. fluctuations, mode interfere brain.In summary, mechanistic connects propagation higher flow. Abnormalities their related contribute question. Two substantial comorbidity mental [32Fishbain D.A. Psychiatric pain-associated co-morbidities.in: McMahon S.B. Wall Melzack's Textbook Elsevier, 2013: 273-282Google dysfunction maintenance neurobiological investigations corroborate crucial showing metabolic 33Rauschecker J.P. al.Frontostriatal gating tinnitus pain.Trends Cogn. 19: 567-578Abstract (19) neurophysiological imaging studies spectrum 34Sarnthein al.Increased EEG power slowed dominant neurogenic pain.Brain. 129: 55-64Crossref (154) 35Stern al.Persistent overactivation patients.Neuroimage. 721-731Crossref (103) Most some causally involved [36Baliki al.Corticostriatal predicts transition 1117-1119Crossref (293) 37Vachon-Presseau E. al.Corticolimbic characteristics predetermine risk 139: 1958-1970Crossref Brain refer rhythmic neural mass (LFPs), electroencephalography (EEG), magnetoencephalography (MEG) [38Panzeri coding: combining microscopic signals.Trends 162-172Abstract most prominent 100 [39Buzsaki G. Draguhn networks.Science. 2004; 304: 1926-1929Crossref (2405) They originate interplay excitation inhibition populations leading periodic potentials. addition, magnetic resonance (fMRI) 1). At any occur bo

Language: Английский

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Corticolimbic anatomical characteristics predetermine risk for chronic pain

Brain, Journal Year: 2016, Volume and Issue: 139(7), P. 1958 - 1970

Published: May 5, 2016

SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back patients longitudinally for 3 years as they either recovered from or transitioned to pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed Intra-corticolimbic connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence functional within the cortex-amygdala-accumbens circuit, well smaller amygdala volume, represented independent risk factors, together accounting 60% variance persistence. Opioid gene polymorphisms negative mood contributed indirectly through corticolimbic anatomical Our results imply that persistence is predetermined by neuroanatomical factors.

Language: Английский

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An amygdalar neural ensemble that encodes the unpleasantness of pain

Science, Journal Year: 2019, Volume and Issue: 363(6424), P. 276 - 281

Published: Jan. 18, 2019

The emotional dimension of pain unpleasantness is an phenomenon distinct from pain's sensory qualities. To study how the brain processes pain-related emotions, Corder et al. used in vivo neural calcium imaging freely behaving mice. They identified circuits that respond to and directly tested their causal role motivational behaviors associated with acute chronic pain. Science , this issue p. 276

Language: Английский

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Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

Nature Reviews Neurology, Journal Year: 2017, Volume and Issue: 13(10), P. 624 - 638

Published: Sept. 8, 2017

Chronic pain is the greatest source of disability globally and claims related to chronic feature in many insurance medico-legal cases. In this Consensus Statement, a presidential task force International Association for Study Pain examines capabilities brain imaging diagnosis pain, ethical legal implications such uses imaging. Brain (for example, functional MRI, PET, EEG magnetoencephalography) widely considered have potential diagnosis, prognostication, prediction treatment outcome patients with pain. its use way. The emphasizes that context discovery phase, but has increase our understanding neural underpinnings inform development therapeutic agents, predict outcomes personalized management. proposes standards evidence must be satisfied before any measure can suitable clinical or purposes. admissibility cases also strongly depends on laws vary between jurisdictions. For these reasons, concludes findings support dispute claim — effectively as lie detector not warranted, should used further mechanisms underlying

Language: Английский

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Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(13), P. 3130 - 3130

Published: June 26, 2019

Chronic pain is a condition in which progresses from an acute to chronic state and persists beyond the healing process. impairs function decreases patients’ quality of life. In recent years, efforts have been made deepen our understanding develop better treatments alleviate pain. this review, we summarize results previous studies, focusing on mechanisms underlying development identification neural areas related We review association between negative affective states. Further, describe structural functional changes brain structures that accompany chronification discuss various neurotransmitter families involved. Our aims provide guidance for future therapeutic approaches could be used management

Language: Английский

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Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain

Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(1), P. 213 - 258

Published: June 11, 2020

Chronic, pathological pain remains a global health problem and challenge to basic clinical sciences. A major obstacle preventing, treating, or reverting chronic has been that the nature of neural circuits underlying diverse components complex, multidimensional experience is not well understood. Moreover, involves maladaptive plasticity processes, which have decoded mechanistically in terms involvement specific cause-effect relationships. This review aims discuss recent advances our understanding circuit connectivity mammalian brain at level regional contributions cell types acute pain. focus placed on functional dissection sub-neocortical using optogenetics, chemogenetics, imaging technological tools rodent models with view towards decoding sensory, affective, motivational-cognitive dimensions The summarizes breakthroughs insights structure-function properties nociceptive higher order modulatory involved aversion, learning, reward, mood their modulation by endogenous GABAergic inhibition, noradrenergic, cholinergic, dopaminergic, serotonergic, peptidergic pathways. knowledge dynamic regulation via structural will be beneficial designing improving targeted therapies.

Language: Английский

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Chronic Pain and Chronic Stress: Two Sides of the Same Coin?

Chronic Stress, Journal Year: 2017, Volume and Issue: 1

Published: Feb. 1, 2017

Pain and stress share significant conceptual physiological overlaps. Both phenomena challenge the body's homeostasis necessitate decision-making to help animals adapt their environment. In addition, chronic pain a common behavioral model of failure extinguish negative memories. Yet, they also have discrepancies such that final brain endophenotype posttraumatic disorder, depression, appears be different among three conditions, role hypothalamic-pituitary-adrenal axis remains unclear in physiology pain. Persistence either or is maladaptive could lead compromised well-being. this brief review, we highlight commonalities differences between pain, while focusing particularly on central limbic brain. We assess current attempts field conceptualize understand within context knowledge gained from literature. The brain-including hippocampus, amygdala, ventromedial pre-frontal cortex-plays critical learning. These areas integrate incoming nociceptive signals with internal state, generate learning necessary for decision-making. Therefore, structural remodeling circuitry observed conditions as linked risk onset these conditions.

Language: Английский

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