Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

Materials, Journal Year: 2022, Volume and Issue: 15(3), P. 804 - 804

Published: Jan. 21, 2022

The strategies involved in the development of therapeutics for neurodegenerative disorders are very complex and challenging due to existence blood-brain barrier (BBB), a closely spaced network blood vessels endothelial cells that functions prevent entry unwanted substances brain. emergence advancement nanotechnology shows favourable prospects overcome this phenomenon. Engineered nanoparticles conjugated with drug moieties imaging agents have dimensions between 1 100 nm could potentially be used ensure enhanced efficacy, cellular uptake, specific transport, delivery molecules brain, owing their modified physico-chemical features. conjugates medicinal plants, or components known as nano phytomedicine, been gaining significance lately novel neuro-therapeutics natural abundance, promising targeted lesser potential show adverse effects. In present review, application, recent trends combined phytomedicine treatment neurological (ND) compared conventional therapies, addressed. Nanotechnology-based efforts performed bioinformatics early diagnosis well futuristic precision medicine ND also discussed context computational approach.

Language: Английский

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Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 135, P. 104583 - 104583

Published: Feb. 22, 2022

Language: Английский

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Effect of Repetitive Transcranial Magnetic Stimulation on Pain Management: A Systematic Narrative Review

Frontiers in Neurology, Journal Year: 2020, Volume and Issue: 11

Published: Feb. 18, 2020

Recently, clinicians have been using repetitive transcranial magnetic stimulation (rTMS) for treating various pain conditions. This systematic narrative review aimed to examine the use and efficacy of rTMS controlling A PubMed search was conducted articles published until June 7, 2019, in which used alleviation. The key phrase identifying potentially relevant [repetitive AND pain]. following inclusion criteria were applied article selection: 1) patients with included, 2) management, 3) after stimulation, follow-up evaluation performed assess reduction pain. Review excluded. Overall, 1030 located. After reading titles abstracts assessing eligibility based on full-text articles, 106 publications finally included. evidence supports that is beneficial neuropathic origins, such as central from peripheral nerve disorders, fibromyalgia, migraine. Data orofacial pain, including trigeminal neuralgia, phantom low back myofascial syndrome, pelvic complex regional are promising but insufficient conclude efficacy. Further studies needed validate effects relief these will help guide making informed decisions regarding whether an appropriate option managing

Language: Английский

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Depression and Pain: Use of Antidepressants

Current Neuropharmacology, Journal Year: 2021, Volume and Issue: 20(2), P. 384 - 402

Published: June 21, 2021

Emotional disorders are common comorbid affectations that exacerbate the severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an excessive duration intensity Clinical preclinical studies have been focused on underlying mechanisms pain depression comorbidity use antidepressants reduce pain.This review provides overview relationship depression, clinical pre-clinical performed neurobiological aspects as analgesics.A systematic search literature databases was conducted according pre-defined criteria. The authors independently a analysis full-text articles.Studies suggest highly intertwined may co-exacerbate physical psychological symptoms. One important biochemical basis for focuses serotonergic norepinephrine system, which shown play role in this comorbidity. Brain structures codify also involved mood. It is evident using strategies commonly employed mitigate Conclusion: Literature indicates impact each other prominent development maintenance Antidepressants continue be major therapeutic tool managing Tricyclic (TCAs) more effective reducing than Selective Serotonin Reuptake Inhibitors (SSRIs) Serotonin- Noradrenaline (SNRIs).

Language: Английский

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Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System

Plants, Journal Year: 2021, Volume and Issue: 11(1), P. 21 - 21

Published: Dec. 22, 2021

Essential oils (EOs) have been traditionally used as ancient remedies to treat many health disorders due their enormous biological activities. As mainstream allopathic medication currently for CNS is associated with adverse effects, the search obtain safer alternatives compared marketed therapies of tremendous significance. Research conducted suggests that concurrent utilization medicines and EOs synergistically beneficial. Due inability show untoward various scientists tried elucidate pharmacological mechanisms by which these exert beneficial effects on CNS. In this regard, our review aims improve understanding EOs’ activity highlight significance in neuronal disorders, thereby improving patient acceptability therapeutic agents. Through data compilation from library searches electronic databases such PubMed, Google Scholar, etc., recent preclinical clinical data, routes administration, required or maximal dosage observation are addressed. We also highlighted challenges require attention further compliance, research gaps, development EO-based nanomedicine targeted therapy pharmacotherapy.

Language: Английский

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The autonomic nervous system: A potential link to the efficacy of acupuncture

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Dec. 8, 2022

The autonomic nervous system (ANS) is a diffuse network that regulates physiological systems to maintain body homeostasis by integrating inputs from the internal and external environment, including sympathetic, parasympathetic, enteric (ENS). Recent evidence suggests ANS one of key neural pathways for acupuncture signal transduction, which has attracted worldwide attention in field. Here, we reviewed basic clinical research published PubMed over past 20 years on effects regulation maintenance. It was found effectively alleviates dysfunction-associated symptoms its indications, such as migraine, depression, insomnia, functional dyspepsia, constipation. Acupuncture stimulation some specific acupoints activates sensory nerve fibers, spinal cord, brain. Using information integration efferents complex nuclei brain, insular cortex (IC), prefrontal cortex, anterior cingulate (ACC), amygdala (AMG), hypothalamus, periaqueductal gray (PAG), nucleus tractus solitarius (NTS), ventrolateral medulla (VLM), ambiguus (AMB), visceral dysfunction, inflammation via efferent nerves, relieves pain affect. modulating pattern sympathetic parasympathetic nerves associated with acupoints, intervention parameters, disease models, relationships among them require further exploration. In conclusion, therapeutic targets mediates acupuncture’s actions, restores homeostasis. A systemic study needed determine rules mechanisms underlying acupoint corresponding organs mediated central networks ANS.

Language: Английский

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Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 11, 2022

Abstract The relationship between pain and depression is thought to be bidirectional the underlying neurobiology ‘shared’ two conditions. However, these claims are often based on qualitative comparisons of brain regions implicated in or depression, while focused quantitative studies pain-depression comorbidity lacking. Particularly, direction comorbidity, i.e., with vs. pain, rarely addressed. In this systematic review (PROSPERO registration CRD42020219876), we aimed delineate correlates associated primary concomitant concurrent equal using activation likelihood estimation (ALE) meta-analysis. Neuroimaging published English until 28th September 2021 were evaluated PRISMA guidelines. A total 70 included, which 26 reported stereotactic coordinates analysed ALE. All assessed for quality by authors, National Institute Health Quality Assessment Tool. Our results revealed paucity that directly investigated comorbidity. ALE analysis indicated was right amygdala, related primarily left dorsolateral prefrontal cortex (DLPFC). We provide evidence have a cumulative negative effect specific set regions, distinct diagnosis pain.

Language: Английский

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Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 122, P. 110520 - 110520

Published: July 19, 2023

Language: Английский

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Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 6, 2023

In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of melatonin (MLT) on neuropathic pain (NP)-induced anxiety depression in a rat model. Adult male rats were separated into four groups, i.e., Sham-VEH: healthy animals received vehicle, Sham-MLT (10 mg/kg), chronic constrictive injury (CCI)-VEH: nerve ligation CCI-MLT. Next, used behavioral tests severity, anxiety, depression. Finally, sacrificed for molecular histopathological studies. Behavioral showed that NP could induce depressive- anxiety-like behaviors. activated NF-κB/NLRP3 inflammasome pathways by upregulating NF-κB, NLRP3, ASC, active Caspase-1, also enhancing concentrations cytokines (IL-1β IL-18) prefrontal cortex (PFC) hippocampus (HC). upregulated Bax, downregulated Bcl2, increased cell apoptosis HC PFC. The treated with MLT eliminated NP, as reduced improved anxiety- depressive-like behaviors, ameliorated pathways, modulated levels promote survival from modulating Bax Bcl2. Therefore, it might be inferred its properties mediate beneficial NP-induced affective disorders.

Language: Английский

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Cold Plasma Therapy in Chronic Wounds—A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(15), P. 5121 - 5121

Published: Aug. 4, 2023

Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma (CPT) holds promise for improving CWs. In light of this, POWER study was conducted as multicenter, randomized trial to investigate effect large-area application compared with SWT patients chronic, non-healing arterial or venous on lower leg. To analyze interim results, we employed comprehensive range statistical tests, including both parametric and non-parametric methods, well GLS model regression an ordinal mixed model. Our findings clearly demonstrate CPT significantly accelerates closure SWT. fact, complete exclusively observed group during intervention period. Additionally, required less antibiotic (4%) (23%). Furthermore, led reduction pain improved quality life conclusion, highlights combination surpasses monotherapy alone.

Language: Английский

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