Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila DOI Creative Commons
Dandan Chen, Divya Sitaraman, Nan Chen

et al.

Nature Communications, Journal Year: 2017, Volume and Issue: 8(1)

Published: July 21, 2017

Animals execute one particular behavior among many others in a context-dependent manner, yet the mechanisms underlying such behavioral choice remain poorly understood. Here we studied how two fundamental behaviors, sex and sleep, interact at genetic neuronal levels Drosophila. We show that an increased need for sleep inhibits male sexual by decreasing activity of male-specific P1 neurons coexpress determination genes fru M dsx, but does not affect female behavior. Further, delineate sex-specific circuit wherein encoding courtship drive suppressed forming mutually excitatory connections with -positive sleep-controlling DN1 neurons. In addition, find FRUM regulates through distinct neural substrates. These studies reveal basis interaction between behaviors Drosophila, provide insights into competing are co-regulated.Genes circuits involved arousal have been extensively authors identify fruitless doublesex, P1-DN1 feedback governs these behaviors.

Language: Английский

Generating parallel representations of position and identity in the olfactory system DOI Creative Commons
István Taisz, Erika Donà, Daniel Münch

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(12), P. 2556 - 2573.e22

Published: May 25, 2023

In Drosophila, a dedicated olfactory channel senses male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in 5-mm range around male. Second-order projection encode the angular position of by detecting inter-antennal concentration, which are amplified through contralateral inhibition. At third circuit layer, identify 47 cell types with diverse input-output connectivity. One population responds tonically flies, second is tuned looming, integrates taste coincidentally promote mating. The separation features resembles mammalian what where visual streams; together multisensory integration, this enables behavioral responses appropriate specific ethological contexts.

Language: Английский

Citations

43
Nested neural circuits generate distinct acoustic signals during Drosophila courtship DOI Creative Commons
Joshua L. Lillvis, Kaiyu Wang, Hiroshi Shiozaki

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(4), P. 808 - 824.e6

Published: Jan. 30, 2024

Many motor control systems generate multiple movements using a common set of muscles. How are premotor circuits able to flexibly diverse movement patterns? Here, we characterize the neuronal that drive distinct courtship songs Drosophila melanogaster. Male flies vibrate their wings toward females produce two different song modes—pulse and sine song—which signal species identity male quality. Using cell-type-specific genetic reagents connectome, provide cellular synaptic map in ventral nerve cord these examine how activating or inhibiting each cell type within affects song. Our data reveal circuit is organized into nested feedforward pathways with extensive reciprocal feedback connections. The larger network produces pulse song, more complex ancestral form. A subset this simpler recent Such organization may be feature which evolution has layered increasing flexibility onto basic pattern.

Language: Английский

Citations

21
Sexual circuitry in Drosophila DOI
Thomas O. Auer, Richard Benton

Current Opinion in Neurobiology, Journal Year: 2016, Volume and Issue: 38, P. 18 - 26

Published: March 3, 2016

Language: Английский

Citations

157
Excitation and inhibition onto central courtship neurons biases Drosophila mate choice DOI Creative Commons

Benjamin R. Kallman,

Hee‐Soo Kim, Kristin Scott

et al.

eLife, Journal Year: 2015, Volume and Issue: 4

Published: Nov. 14, 2015

The ability to distinguish males from females is essential for productive mate selection and species propagation. Recent studies in Drosophila have identified different classes of contact chemosensory neurons that detect female or male pheromones influence courtship decisions. Here, we examine central neural pathways the brain process using anatomical, calcium imaging, optogenetic, behavioral studies. We find sensory pheromones, but not activate a novel class ventral nerve cord cause activation P1 neurons, male-specific command trigger courtship. In addition, as well those mAL inhibit P1. These demonstrate balance excitatory inhibitory drives onto courtship-promoting controls mating

Language: Английский

Citations

145
Visual Projection Neurons Mediating Directed Courtship in Drosophila DOI Creative Commons
Inês Ribeiro,

Michael Drews,

Armin Bahl

et al.

Cell, Journal Year: 2018, Volume and Issue: 174(3), P. 607 - 621.e18

Published: July 1, 2018

Language: Английский

Citations

145
Dopaminergic Circuitry Underlying Mating Drive DOI Creative Commons
Stephen X. Zhang, Dragana Rogulja, Michael A. Crickmore

et al.

Neuron, Journal Year: 2016, Volume and Issue: 91(1), P. 168 - 181

Published: June 12, 2016

Language: Английский

Citations

143
Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success DOI Creative Commons
Hui‐Hao Lin,

De-Shou Cao,

Sachin Sethi

et al.

Neuron, Journal Year: 2016, Volume and Issue: 90(6), P. 1272 - 1285

Published: June 1, 2016

Language: Английский

Citations

128
The Neural Circuitry that Functions as a Switch for Courtship versus Aggression in Drosophila Males DOI Creative Commons
Masayuki Koganezawa,

Ken-ichi Kimura,

Daisuke Yamamoto

et al.

Current Biology, Journal Year: 2016, Volume and Issue: 26(11), P. 1395 - 1403

Published: May 12, 2016

Language: Английский

Citations

126
Neuromodulation of Innate Behaviors in Drosophila DOI

Susy M. Kim,

Chih‐Ying Su, Jing W. Wang

et al.

Annual Review of Neuroscience, Journal Year: 2017, Volume and Issue: 40(1), P. 327 - 348

Published: April 25, 2017

Animals are born with a rich repertoire of robust behaviors that critical for their survival. However, innate also highly adaptable to an animal's internal state and external environment. Neuromodulators, including biogenic amines, neuropeptides, hormones, released signal changes in animals' circumstances serve reconfigure neural circuits. This circuit flexibility allows animals modify behavioral responses according environmental cues, metabolic demands, physiological states. Aided by powerful genetic tools, researchers have made remarkable progress Drosophila melanogaster address how myriad contextual information influences the input-output relationship hardwired circuits support complex repertoire. Here we highlight recent advances understanding neuromodulation behaviors, special focus on feeding, courtship, aggression, postmating behaviors.

Language: Английский

Citations

103
Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila DOI Creative Commons

Yonil Jung,

Ann Kennedy, Hui Chiu

et al.

Neuron, Journal Year: 2019, Volume and Issue: 105(2), P. 322 - 333.e5

Published: Dec. 3, 2019

Language: Английский

Citations

96