Journal of Cerebral Blood Flow & Metabolism,
Journal Year:
2018,
Volume and Issue:
39(2), P. 189 - 209
Published: Oct. 30, 2018
The
mammalian
brain
is
composed
of
densely
connected
and
interacting
regions,
which
form
structural
functional
networks.
An
improved
understanding
the
structure–function
relation
crucial
to
understand
underpinnings
function
plasticity
after
injury.
It
currently
unclear
how
connectivity
strength
relates
strength.
We
obtained
an
overview
recent
papers
that
report
on
correspondences
between
quantitative
measures
in
brain.
included
network
studies
was
measured
with
resting-state
fMRI,
either
diffusion-weighted
MRI
or
neuronal
tract
tracers.
Twenty-seven
28
showed
a
positive
relationship.
Large
inter-study
variations
were
found
comparing
diffusion-based
(correlation
coefficient
(r)
ranges:
0.18–0.82)
tracer-based
(r
=
0.24–0.74).
Two
datasets
demonstrated
lower
correlations
0.22
r
0.30)
than
0.49
0.65).
robust
relationship
supports
hypothesis
provides
hardware
from
emerges.
However,
methodological
differences
complicate
comparison
across
studies,
emphasize
need
for
validation
standardization
studies.
Proceedings of the National Academy of Sciences,
Journal Year:
2018,
Volume and Issue:
115(24), P. 6297 - 6302
Published: May 30, 2018
Significance
We
show
that
the
combination
of
topology
and
geometry
in
mammalian
cortical
networks
allows
for
near-optimal
decentralized
communication
under
navigation
routing.
Following
a
simple
propagation
rule
based
on
local
knowledge
distance
between
regions,
we
demonstrate
brain
can
be
successfully
navigated
with
efficiency
is
comparable
to
shortest
paths
This
finding
helps
conciliate
major
progress
achieved
over
more
than
decade
connectomics
research,
assumption
via
paths,
recent
questions
raised
by
biologically
unrealistic
requirements
involved
computation
optimal
routes.
Our
results
reiterate
importance
brain’s
spatial
embedding,
suggesting
three-way
relationship
connectome
geometry,
topology,
communication.
Psychophysiology,
Journal Year:
2017,
Volume and Issue:
55(3)
Published: Nov. 28, 2017
Abstract
Executive
control
functions
are
associated
with
frontal,
parietal,
cingulate,
and
insular
brain
regions
that
interact
through
distributed
large‐scale
networks.
Here,
we
discuss
how
fMRI
functional
connectivity
can
shed
light
on
the
organization
of
networks
they
other
parts
brain.
In
first
section
our
review,
present
convergent
evidence
from
connectivity,
activation,
lesion
studies
there
multiple
dissociable
in
distinct
properties.
second
section,
graph
theoretical
concepts
help
illuminate
mechanisms
by
which
to
carry
out
goal‐directed
functions,
focusing
role
specialized
hub
for
mediating
cross‐network
interactions.
Again,
use
a
combination
lesion,
task
activation
bolster
this
claim.
We
conclude
network
perspective
provides
important
neurobiological
constraints
neural
underpinnings
executive
control,
will
guide
future
basic
translational
research
into
function
its
disruption
disease.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Oct. 11, 2019
Abstract
Designer
Receptors
Exclusively
Activated
by
Drugs
(DREADDs)
are
a
popular
chemogenetic
technology
for
manipulation
of
neuronal
activity
in
uninstrumented
awake
animals
with
potential
human
applications
as
well.
The
prototypical
DREADD
agonist
clozapine
N-
oxide
(CNO)
lacks
brain
entry
and
converts
to
clozapine,
making
it
difficult
apply
basic
translational
applications.
Here
we
report
the
development
two
novel
agonists,
JHU37152
JHU37160,
first
dedicated
18
F
positron
emission
tomography
(PET)
radiotracer,
[
F]JHU37107.
We
show
that
JHU37160
exhibit
high
vivo
potency.
F]JHU37107
combined
PET
allows
detection
locally-targeted
neurons,
at
their
long-range
projections,
enabling
noninvasive
longitudinal
projection
mapping.
Cell Reports,
Journal Year:
2019,
Volume and Issue:
28(10), P. 2527 - 2540.e9
Published: Sept. 1, 2019
Stroke
causes
focal
brain
lesions
that
disrupt
functional
connectivity
(FC),
a
measure
of
activity
synchronization,
throughout
distributed
networks.
It
is
often
assumed
FC
disruptions
reflect
damage
to
specific
cortical
regions.
However,
an
alternative
explanation
they
the
structural
disconnection
(SDC)
white
matter
pathways.
Here,
we
compare
these
explanations
using
data
from
114
stroke
patients.
Across
multiple
analyses,
find
SDC
measures
outperform
measures,
including
putative
critical
regions,
for
explaining
associated
with
stroke.
We
also
identify
core
mode
structure-function
covariation
links
severity
interhemispheric
SDCs
widespread
across
patients
and
correlates
deficits
in
behavioral
domains.
conclude
lesion's
impact
on
connectome
what
determines
its
may
play
particularly
important
role
mediating
after
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Feb. 25, 2022
Abstract
While
shaped
and
constrained
by
axonal
connections,
fMRI-based
functional
connectivity
reorganizes
in
response
to
varying
interareal
input
or
pathological
perturbations.
However,
the
causal
contribution
of
regional
brain
activity
whole-brain
fMRI
network
organization
remains
unclear.
Here
we
combine
neural
manipulations,
resting-state
vivo
electrophysiology
probe
how
inactivation
a
cortical
node
causally
affects
brain-wide
coupling
mouse.
We
find
that
chronic
inhibition
medial
prefrontal
cortex
(PFC)
via
overexpression
potassium
channel
increases
between
inhibited
area
its
direct
thalamo-cortical
targets.
Acute
chemogenetic
PFC
produces
analogous
patterns
overconnectivity.
Using
electrophysiology,
enhances
low
frequency
(0.1–4
Hz)
oscillatory
power
suppression
firing
not
phase-locked
slow
rhythms,
resulting
increased
δ
band
coherence
areas
exhibit
These
results
provide
evidence
can
counterintuitively
increase
enhanced,
less-localized
processes.
Cell Reports,
Journal Year:
2019,
Volume and Issue:
28(10), P. 2554 - 2566.e7
Published: Sept. 1, 2019
Optimizing
direct
electrical
stimulation
for
the
treatment
of
neurological
disease
remains
difficult
due
to
an
incomplete
understanding
its
physical
propagation
through
brain
tissue.
Here,
we
use
network
control
theory
predict
how
spreads
white
matter
influence
spatially
distributed
dynamics.
We
test
theory's
predictions
using
a
unique
dataset
comprising
diffusion
weighted
imaging
and
electrocorticography
in
epilepsy
patients
undergoing
grid
stimulation.
find
statistically
significant
shared
variance
between
predicted
activity
state
transitions
observed
transitions.
then
optimal
framework
posit
testable
hypotheses
regarding
which
states
structural
properties
will
efficiently
improve
memory
encoding
when
stimulated.
Our
work
quantifies
role
that
architecture
plays
guiding
dynamics
offers
empirical
support
utility
explaining
brain's
response
